COBRE: UVM MED: CORE A: ADMINISTRATIVE & INTELLECTUAL CORE

COBRE：UVM MED：核心 A：行政

• 批准号: 7959682
• 负责人: Rodney L Parsons
• 金额: $ 50.5万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959682
• 关键词: Advisory Committees; Applications Grants; Award; Back; Basic Science; Behavior; Biology; Cells; Centers of Research Excellence; Clinical; Cognitive; Committee Members; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Critiques; Development; Effectiveness; Equipment; Eye Movements; Faculty; Fellowship; Funding; Future; Goals; Grant; Hour; Image; Institutes; Institution; Laboratories; Malignant Neoplasms; Manuscripts; Measures; Medicine; Mentors; Microbiology; Molecular; Molecular Genetics; Molecular and Cellular Biology; Neurobiology; Neurosciences; Neurosciences Research; New York; Oral; Pattern; Pharmacology; Physiology; Probability; Process; Psychiatry; Psychology; Psychopathology; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Role; Societies; Source; Students; Study Section; Suggestion; Time; Training; Training Programs; Underrepresented Minority; United States National Institutes of Health; Universities; Vermont; Visit; Wages; Work; base; college; falls; graduate student; human subject; insight; lectures; medical schools; meetings; member; nervous system disorder; posters; programs; research and development; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of the Center of Biomedical Research Excellence in Neuroscience (Neuroscience COBRE) has been to enhance the infrastructure of neuroscience research and graduate training across the University of Vermont (UVM) campus. During the past year, which represents the eighth year of funding, the Neuroscience COBRE continued to have two main aims: (1) to support the research and intellectual infrastructure of a University-wide Center for Neuroscience Excellence at UVM, and (2) to promote the research development of neuroscience faculty who will be the future leaders in the UVM Center for Neuroscience Excellence. Significant progress continues to be made in meeting these goals. The role of the Administrative Core is to provide both intellectual and administrative support for the Neuroscience COBRE. The Administrative Core oversees the mentoring program which provides critical guidance for our four COBRE-supported investigators: Drs. Miguel Martin-Caraballo from the Department of Biology, Alan Howe from the Department of Pharmacology, Jeffrey Spees from the Department of Medicine and Uma Wesley from the Department of Molecular Genetics and Microbiology. Faculty mentoring is a major emphasis of this program, and senior faculty members guide the research activities of each of these four COBRE-supported neuroscience investigators. The staff within the Administrative Core process purchase orders and salary distributions and provide ongoing financial analysis for all Project and Core Directors. The Administrative Core also supports new Neuroscience faculty hires. During this past year, Neuroscience COBRE funds were used to support the needs of two faculty members: Drs. Robert Althoff and Jom Hammack. Dr. Althoff, a new faculty member in the Department of Psychiatry, is developing a research program on the basic cognitive and autonomic processes underlying developmental psychopathology. COBRE funds allowed him to acquire equipment critically needed for analysis of eye movements in human subjects to support this work. COBRE funds were also expended to provide technical support for Dr. Hammack (Department of Psychology), a junior neuroscientist who was supported by recruitment funds during the initial COBRE award. The Neuroscience COBRE grant continues to support two multi-user research core facilities: the Cellular/Molecular Biology Core and Imaging/Physiology Core. These cores were established by the initial COBRE award to provide access to research tools critical to the work proposed in the four neuroscience faculty projects and to support research programs by many other UVM neuroscientists. This year, one focus of the annual review by the External Advisory Committee was an assessment of these two research Cores. Each of the Core Directors presented an overview of the Core, describing specialized equipment items, activities and usage patterns. The two External Review Committee members, Drs John Bixby and Steven Heinemann, who visited UVM this March (see below), enthusiastically supported the Core activities. In the accompanying report, they indicated the cores were very successful in supporting the COBRE investigators and many other UVM researchers, as measured by the increasing number of users. They also were supportive of the acquisition of additional equipment over the past few years to meet the needs of the user group. The Translational Core, a third core developed in year 2 of the initial funding period, facilitates interaction between basic and clinical neuroscientists. The Translational Core supports a didactic course, entitled Basic Science of Neurological Diseases, which is presented to graduate students, residents, and faculty. This past year, Core Co-Director Dr. Felix Eckenstein organized and administered the COBRE-supported Summer Neuroscience Undergraduate Research Fellowship. Nine undergraduate students participated in this ten-week research intense program with their stipends and lodging expenses paid by Translational Core funds. Three of the nine were underrepresented minority students. This past year over 160 undergraduate students applied for the program. The Administrative Core also supported a plenary Neuroscience lecture, which was presented by Dr. Lorna Role, Chair of the Department of Neurobiology and Behavior at the State University of New York at Stony Brook. This presentation was part of the annual neuroscience retreat held January 23-24, 2009 and sponsored jointly by the Neuroscience COBRE and the local Vermont Chapter of the Society for Neuroscience. This retreat was organized to highlight neuroscience research accomplishments at UVM and consisted of oral and poster presentations by neuroscientists from departments across the UVM campus. The Administrative Core organized the Annual COBRE Review held March 8-10. The objectives and format of the annual review by the External Advisory Committee was somewhat different this year from that of prior years. There were two major goals of the review. The first objective was to review the progress and effectiveness of the two Neuroscience COBRE-supported research core facilities: the Cell/Molecular Core and Imaging/Physiology Core. The second goal was to evaluate the progress of the four COBRE-supported research project directors and provide input into whether each of the Project Directors should continue to receive COBRE support for the remaining two years of the grant. Two members of the External Advisory Committee (Drs. John Bixby, University of Miami Medical School and Steven Heinemann, Salk Institute) visited UVM this year. As part of their review, Drs Bixby and Heinemann evaluated the Cell/Molecular Core and Imaging/Physiology Core. The two research core directors, Mr. Todd Clason and Dr. Sheryl White, presented a detailed overview of core activities and accomplishments to Drs. Bixby and Heinemann and members of the Neuroscience COBRE Internal Advisory Board, COBRE project directors and their faculty mentors. This was a very constructive interaction with a number of good ideas generated about how to continue to strengthen core capabilities and increase usage. As part of the core review, Drs. Bixby and Heinemann toured both facilities to see the physical layout of each core. Drs. Bixby and Heinemann enthusiastically supported both core directors and felt that the cores provided critical research support to neuroscience as well as other investigators at UVM. On the afternoon of March 9, Drs. Bixby and Heinemann met sequentially for 2 hours with Dr. Alan Howe and Dr. Miguel Martin-Caraballo to review their progress and discuss Specific Aims for potential grant applications. The 2-hour time block allowed Drs. Howe and Martin-Caraballo to have an in depth discussion with the two external reviewers about their research programs. Both External Reviewers thought that this was an excellent format for the discussion. Based on information provided prior to the meeting (including copies of prior grants, study section critiques and manuscripts) and obtained in the discussion, they recommended that Dr. Martin-Caraballo receive 2 more years of COBRE support, but that Dr. Howe should receive only one year of support. Their decision was based on their concern about limited progress to date on the COBRE funded project and the high probability that the proposed studies will not generate sufficient new significant information after next year. Thus, they indicated it would be better for Dr. Howe to complete the work in progress, complete manuscripts related to these studies and then shift his emphasis back to his other ongoing, funded cancer-related projects (see External Advisory Committee Report). The other two members of the External Advisory Committee (Drs. William Mobley, Stanford University Medical School and Mahendra Rao, Vice President for Research, Invitrogen Corp.) did not visit UVM this time. Rather, they were sent copies of grant applications submitted last Fall by the two other COBRE Project Directors: Dr. Jeffrey Spees and Dr. Uma Wesley. They also were sent copies of the study section critiques of these applications. Unfortunately, neither grant was scored, but both Dr. Spees and Dr. Wesley have been encouraged to resubmit this Spring/Summer cycle. The input from Drs. Rao and Mobley has provided important insight into how these grants can be revised to meet the suggestions of the study section members. Both Dr. Spees and Wesley have made significant progress and will receive support for the 2 years remaining on the grant. A major accomplishment made during the first COBRE funding period was the development of a university-wide Neuroscience Doctoral Training Program. The current COBRE grant continues to support this multi-disciplinary graduate training program in Neuroscience as many of the participating faculty members are involved with the Neuroscience COBRE. Stipends for graduate students working in the laboratories of the four Project Directors are made available through COBRE funding. The training faculty is derived from multiple departments in many Colleges across the campus, creating a breadth of training opportunities that is truly diverse. We are currently finishing the third year of this program and both the number and quality of student applications to the program has increased markedly. Dr. Rae Nishi, a COBRE mentor and member of the Internal Advisory Board, continues in her role as Graduate Program Director.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 神经科学卓越生物医学研究中心（Neuroscience Cobre）的主要目标是增强佛蒙特大学（UVM）校园的神经科学研究和研究生培训的基础设施。 在代表资金第八年的过去一年中，神经科学柯布雷继续具有两个主要目的：（1）支持UVM大学范围内神经科学卓越中心的研究和知识基础设施，以及（2），以促进Neuroscience教职员工的研究发展，他们将成为Neuroscience Neuroscience in Neuroscience in Neuroscience in Neuroscience in Neuroscience中的卓越中心。 实现这些目标时，仍在继续取得重大进展。 行政核心的作用是为神经科学毛病提供智力和行政支持。 行政核心负责监督指导计划，该计划为我们的四个由玉米鞋支撑的调查人员提供了关键指导：Drs。来自药理学系Alan Howe的生物学系的Miguel Martin-Caraballo，医学系的Jeffrey Spees和分子遗传学和微生物学系的UMA Wesley。 教师指导是该计划的主要重点，高级教职员工指导了这四个由鞋垫支持的神经科学研究者的研究活动。 行政核心流程采购订单和工资分配中的员工，并为所有项目和核心董事提供持续的财务分析。 行政核心还支持新的神经科学教师雇用。 在过去的一年中，使用神经科学的鞋底资金来支持两位教职员工的需求：Drs。罗伯特·阿尔瑟夫（Robert Althoff）和乔姆·哈马克（Jom Hammack）。 Althoff博士是精神病学系的新教职员工，正在制定有关发展心理病理学基础认知和自主过程的研究计划。 柯布尔资金使他能够为分析人类受试者的眼动分析以支持这项工作所需的设备。 还支出了COBRE资金，以为Hammack博士（心理学系）提供技术支持，这是一名初级神经科学家，在最初的Cobre奖中得到了招聘资金的支持。 神经科学的毛刺赠款继续支持两个多用户研究核心设施：细胞/分子生物学核心和成像/生理核心。 这些核心是由最初的Cobre Award建立的，目的是对四个神经科学教师项目提出的工作至关重要的研究工具，并支持许多其他UVM神经科学家的研究计划。 今年，外部咨询委员会的年度审查重点是对这两个研究核心的评估。 每个核心主管都概述了核心，描述了专业的设备项目，活动和使用模式。 两个外部审查委员会成员约翰·比克斯比（John Bixby）和史蒂文·海尼曼（Steven Heinemann）博士于今年3月访问了UVM（见下文），热情地支持了核心活动。 在随附的报告中，他们指出，根据用户数量越来越多的用户衡量，核心在支持Cobre调查人员和许多其他UVM研究人员方面非常成功。 他们还支持在过去几年中收购其他设备以满足用户组的需求。 转化核心是在初始资助期的第2年发展的第三个核心，促进了基本和临床神经科学家之间的相互作用。 翻译核心支持了一个教学课程，题为《神经疾病的基础科学》，该课程呈现给研究生，居民和教职员工。 过去的一年，核心联合导演费利克斯·埃肯斯坦（Felix Eckenstein）博士组织并管理了鞋底支持的夏季神经科学本科生研究奖学金。 九名本科生参加了这项为期十周的研究激烈计划，其津贴和住宿费用由转化核心基金支付。 九个人中有三个是少数族裔学生的分数不足。 在过去的一年中，有160名本科生申请了该计划。 行政核心还支持全体神经科学讲座，该讲座是由纽约州立大学斯托尼·布鲁克（Stony Brook）神经生物学与行为学系主席洛娜（Lorna）角色发表的。 该演讲是2009年1月23日至24日举行的年度神经科学务虚会的一部分，并由神经科学鞋底和神经科学学会的当地佛蒙特州共同赞助。 该务虚会的组织是为了强调UVM的神经科学研究成就，由来自UVM校园各部门的神经科学家的口头和海报演讲组成。 行政核心组织了3月8日至10日举行的年度COBRE审查。 外部咨询委员会的年度审查目标和格式与今年的年度审查有所不同。 审查有两个主要目标。 第一个目标是回顾两种神经科学脚底研究的研究核心设施的进度和有效性：细胞/分子核心和成像/生理核心。 第二个目标是评估四个牢固支持的研究项目主管的进度，并向每个项目董事是否应继续为剩余的两年赠款获得鞋底支持。 外部咨询委员会的两名成员（迈阿密大学医学院和史克研究所的史蒂文·海尼曼博士）今年访问了UVM。 作为回顾的一部分，Bixby博士和Heinemann评估了细胞/分子核心和成像/生理核心。 两位研究核心主管Todd Clason先生和Sheryl White博士详细介绍了Drs的核心活动和成就。 Bixby和Heinemann以及Neuroscience Cobre内部顾问委员会，Cobre Project Project董事及其教职员工的成员。 这是一种非常有建设性的互动，关于如何继续增强核心功能并增加用法的许多好主意。 作为核心评论的一部分，博士。 Bixby和Heinemann参观了这两个设施，以查看每个核心的物理布局。 博士。 Bixby和Heinemann热情地支持了这两个核心主管，并认为核心为神经科学以及UVM的其他研究人员提供了重要的研究支持。 3月9日下午，博士。 Bixby和Heinemann依次与Alan Howe博士和Miguel Martin-Caraballo博士依次开会2个小时，以审查其进度，并讨论了潜在赠款申请的具体目标。 2小时的时间块允许Drs。 Howe和Martin-Caraballo与两位外部审阅者有关其研究计划进行深入讨论。 两位外部评论者都认为这是讨论的绝佳格式。 基于会议前提供的信息（包括先前的赠款，研究部分的批评和手稿），并在讨论中获得的信息，他们建议Martin-Caraballo博士再获得2年的Cobre支持，但Howe博士只能获得一年的支持。 他们的决定是基于他们对迄今为止在山谷资助的项目上的有限进展的关注，以及拟议的研究在明年之后不会产生足够新的重要信息的很高可能性。 因此，他们表示，豪博士完成正在进行的工作，完成与这些研究相关的手稿，然后将他的重点转移到他的其他正在进行的，与癌症相关的项目（请参阅外部咨询委员会报告）。 外部咨询委员会的其他两个成员（威廉·莫布利博士，斯坦福大学医学院博士和Invitrogen Corp.研究副总裁Mahendra Rao）这次没有访问UVM。 相反，他们是由其他两位Cobre项目董事杰弗里·斯皮斯（Jeffrey Spees）和乌玛·韦斯利（Uma Wesley）博士发送的去年秋天提交的赠款申请的副本。 他们还收到了这些应用程序的研究部分评论的副本。 不幸的是，格兰特都没有得分，但是斯皮斯博士和韦斯利博士都被鼓励在今年春季/夏季的周期重新提交。 DRS的输入。 Rao和Mobley对如何修改这些赠款以满足研究部分成员的建议提供了重要的见解。 Spees博士和卫斯理博士都取得了重大进展，并将在赠款剩下的两年中获得支持。 在第一个毛cre资金期间取得的重大成就是开发了大学范围内的神经科学博士培训计划。 目前的毛赠水继续支持神经科学的这项跨学科研究生培训计划，因为许多参与的教职员工都参与了神经科学的柯布雷。 在四个项目主管的实验室工作的研究生的津贴可通过Cobre资助提供。 培训学院来自校园中许多大学的多个学院，创造了真正多样化的培训机会。 我们目前正在完成该计划的第三年，并且该计划的学生申请的数量和质量都显着增加。 鞋底导师兼内部顾问委员会成员Rae Nishi博士继续担任研究生计划主任。