Audiological and Genetic Resource for Pediatric Hearing Research

儿科听力研究的听力学和遗传资源

基本信息

批准号：
7850387
负责人：
E Bryan Crenshaw
金额：
$ 16.22万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-17 至 2011-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7850387
关键词：
Address Area Authorization documentation Biomedical Computing Budgets Cell Line Characteristics Child Childhood Cities Clinic Clinical Clinical Research Clinical Trials Controlled Vocabulary Data Data Set Databases Development Disclosure Effectiveness Enrollment Ensure Environmental Risk Factor Evaluation Face Family First Name Genetic Genetic Databases Genetic Materials Genotype Grant Guidelines Healthcare Hearing Human Resources Human Subject Research Individual Institution Instruction Investigation Last Name Letters Literature Manuscripts Maps Medical Methods Minority Modeling Monitor Names Ontology Other Genetics Outcome Patients Pediatric Hospitals Phase Philadelphia Policies Policy Research Positioning Attribute Principal Investigator Printing Procedures Process Public Health Publications Research Research Design Research Infrastructure Research Personnel Research Project Grants Resource Sharing Resources Role Safety Screening procedure Security Structure Terminology Testing Therapeutic Intervention Time United States Vertebrates Woman base clinical application cohort computer infrastructure computing resources data modeling early onset genetic resource hearing impairment high risk human embryonic stem cell human subject protection interest literature survey medical specialties meetings patient oriented performance site programs quality assurance repository research study web based interface

项目摘要

Project Summary: The overall objective of this application is to develop an integrated biomedical-computing infrastructure incorporating audiologic, otologic and genetic patient data that will meet the needs of investigators pursuing patient-oriented pediatric hearing research. As the largest pediatric health-care network in the United States, the Children's Hospital of Philadelphia (CHOP) is uniquely positioned to develop a computational infrastructure for patient data acquired through screening and comprehensive evaluation of pediatric patients with congenital, early-onset, progressive and acquired forms of hearing loss. In the first phase of the application (R21), the overall approach required for building a biomedical-computing infrastructure will be determined. Subsequently, a proof-of-concept query of the database containing a limited critical set of data from existing audiologic and genetic databases at CHOP will be demonstrated. In the second (R33) phase of the application, we will expand the database to incorporate biomedical characteristics data and genetic material from a large patient cohort, and develop a web-based interface for scientific inquiry of the database in a manner that ensures anonymity of patient information.

项目概要：该应用程序的总体目标是开发集成的生物医学计算基础设施整合听力学、耳科和遗传患者数据，以满足研究人员的需求以患者为导向的儿科听力研究。作为美国最大的儿科医疗保健网络，费城儿童医院 (CHOP) 具有独特的优势来开发计算通过儿科患者筛查和综合评估获得的患者数据基础设施先天性、早发性、进行性和后天性听力损失。在第一阶段应用程序（R21），构建生物医学计算基础设施所需的总体方法将是决定。随后，对包含有限关键数据集的数据库进行概念验证查询来自 CHOP 现有听力学和遗传数据库的数据将得到证明。在第二阶段（R33）该应用程序，我们将扩展数据库以纳入生物医学特征数据和遗传数据来自大量患者队列的材料，并开发一个基于网络的界面，用于数据库的科学查询以确保患者信息匿名的方式。