Audiological and Genetic Resource for Pediatric Hearing Research

儿科听力研究的听力学和遗传资源

基本信息

批准号：
7764646
负责人：
E Bryan Crenshaw
金额：
$ 65.14万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-01 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7764646
关键词：
Address Area Biomedical Computing Characteristics Child Childhood Clinical Controlled Vocabulary Data Data Set Databases Development Effectiveness Ensure Environmental Risk Factor Evaluation Family Genetic Genetic Databases Genetic Materials Genotype Grant Guidelines Healthcare Hearing Individual Institution Investigation Maps Medical Modeling Ontology Other Genetics Outcome Patients Pediatric Hospitals Phase Philadelphia Policies Policy Research Positioning Attribute Procedures Process Public Health Research Research Infrastructure Research Personnel Resources Screening procedure Security Structure Terminology Testing Therapeutic Intervention United States base clinical application cohort computer infrastructure computing resources data modeling early onset genetic resource hearing impairment high risk interest literature survey medical specialties meetings patient oriented programs quality assurance relational database repository web based interface

项目摘要

Project Summary: The overall objective of this application is to develop an integrated biomedical-computing infrastructure incorporating audiologic, otologic and genetic patient data that will meet the needs of investigators pursuing patient-oriented pediatric hearing research. As the largest pediatric health-care network in the United States, the Children's Hospital of Philadelphia (CHOP) is uniquely positioned to develop a computational infrastructure for patient data acquired through screening and comprehensive evaluation of pediatric patients with congenital, early-onset, progressive and acquired forms of hearing loss. In the first phase of the application (R21), the overall approach required for building a biomedical-computing infrastructure will be determined. Subsequently, a proof-of-concept query of the database containing a limited critical set of data from existing audiologic and genetic databases at CHOP will be demonstrated. In the second (R33) phase of the application, we will expand the database to incorporate biomedical characteristics data and genetic material from a large patient cohort, and develop a web-based interface for scientific inquiry of the database in a manner that ensures anonymity of patient information. Relevance: Progress on many research and policy issues in pediatric hearing loss are being hampered due to insufficient biomedical computing resources. In particular, an integrated relational database of audiologic, otologic, genetic and other medical data would profoundly facilitate critical biomedical investigations that are both important to individual families and to public health and educational policy planning. By establishing such a resource, researchers and clinicians could more effectively address how underlying genetic and environmental factors influence the effectiveness and outcome of patient-directed therapies and interventions. These efforts will facilitate effective identification of pediatric patients at high risk for congenital or late onset hearing loss, directed assessment of the audiologic and otologic features of children with all forms of hearing loss, and characterization of the genetic basis for hearing loss

项目摘要：该应用的总体目的是开发集成的生物医学计算基础设施合并听力学，耳科和遗传患者数据，这些数据将满足追求的调查人员的需求面向患者的儿科听力研究。作为美国最大的儿科医疗网络，费城儿童医院（CHOP）的独特位置可以开发计算通过筛查和对儿科患者的全面评估获得的患者数据基础设施先天性，早期，进步和获得的听力损失形式。在第一阶段应用（R21），建立生物医学计算基础设施所需的总体方法将是决定。随后，包含有限的关键数据集的数据库的概念验证查询将展示从现有的听力学和遗传数据库中。在第二个（R33）阶段应用程序，我们将扩展数据库，以结合生物医学特征数据和遗传来自大型患者队列的材料，并开发基于网络的界面，以科学查询数据库以确保患者信息匿名的方式。关联：由于生物医学计算资源不足。特别是听力学的综合关系数据库，耳科，遗传和其他医学数据将深刻促进重要的生物医学研究对个人家庭以及公共卫生和教育政策计划都很重要。通过建立这样的资源，研究人员和临床医生可以更有效地解决遗传和环境因素影响患者指导疗法的有效性和结果干预措施。这些努力将有助于有效识别先天性高风险的小儿患者或延迟发作听力损失，对所有人的听力和耳科特征进行定向评估听力损失的形式和听力损失的遗传基础的表征