Trends in Associations between Maternal Methamphetamine Use and Congenital Syphilis in Los Angeles County, 2011 through 2020

2011 年至 2020 年洛杉矶县母亲甲基苯丙胺使用与先天性梅毒之间的关联趋势

• 批准号: 10678416
• 负责人: Eunhee Park
• 金额: $ 4.23万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678416
• 关键词: Address; Affect; Age; Area; Authorization documentation; Blindness; California; Child; Cocaine; Collaborations; Congenital Syphilis; Contracts; County; Data; Data Analyses; Data Set; Data Sources; Deformity; Development; Diagnosis; Disease Surveillance; Educational workshop; Epidemic; Epidemiology; Equation; Ethics; Family; Female; Fright; HIV; Health; Hepatitis; Heroin; Homelessness; Imprisonment; Incidence; Individual National Research Service Award; Infant; Infection; Injecting drug user; Injections; Instruction; Intervention; Knowledge; Link; Los Angeles; Maternal and Child Health; Measures; Mediation; Mentors; Mentorship; Methamphetamine; Methods; Modeling; Mothers; Outcome; Outcome Study; Outcomes Research; Persons; Pharmaceutical Preparations; Population; Positioning Attribute; Poverty; Pregnancy; Pregnant Women; Prenatal care; Public Health; Publishing; Readiness; Recording of previous events; Reporting; Reproductive Health; Research; Research Personnel; Risk; Risk Factors; STI prevention; Sample Size; San Francisco; Services; Sexual Partners; Sexually Transmitted Diseases; Substance Use Disorder; Syphilis; System; Testing; Time trend; Training; Training Activity; Transact; Treponema pallidum; United States; Universities; Vertical Disease Transmission; Visit; Woman; authority; bone; care providers; career; condoms; deafness; experience; high risk sexual behavior; longitudinal analysis; marginalization; maternal methamphetamine use; men; men who have sex with men; methamphetamine use; methamphetamine user; metropolitan; multilevel analysis; pilot test; pre-doctoral; programs; recreational drug use; reproductive; responsible research conduct; sex; skills; social; social stigma; social vulnerability; statistics; stillbirth; substance abuse epidemiology; substance use; surveillance data; syndemic; theories; trend; trend analysis

PROJECT SUMMARY/ABSTRACT The purpose of the Predoctoral Individual National Research Service Award (F31) is to provide the candidate with mentoring and research experiences that will promote candidate’s development as an independent researcher, with particular emphasis in spatial-temporal trend and longitudinal analysis as well as multi-level modeling in maternal and child health among populations diagnosed with syphilis. Objectives of the training are to develop knowledge and skills to: 1) gain research experience using state-of-the-art methods using a large longitudinal surveillance dataset and publish the research findings as the first author; 2) advance epidemiological training focused on knowledge of the epidemiology of substance abuse and sexually transmitted infections and gain statistical skills for mediation and longitudinal analyses; and 3) obtain Skills for a successful academic career and professional development, including ethics, the dissemination of research findings, and the development of collaborative scientific relationships. Training activities will include didactic coursework and specific workshops, directed readings and one-on-one tutorials with mentors, and instruction in the responsible conduct of research. The candidate will receive mentorship from a Training Committee comprised of nationally renowned experts in the fields of substance use, maternal and child health, sexually transmitted diseases (STDs), and longitudinal data analysis at the University of California, Los Angeles. The specific aims of the proposed research are to: 1) measure spatial-temporal trends in methamphetamine (meth) use incidence rates among women of reproductive age (15-44 years old), pregnant women, and congenital syphilis (CS) case mothers who are diagnosed with syphilis in Los Angeles County between 2011 and 2020; 2) determine whether temporal trends in prenatal care visits, syphilis treatment during pregnancy, and delivery of infants with CS among pregnant women diagnosed with syphilis differ by meth use; and 3) apply syndemic theory to examine meth use, high-risk sexual behaviors, homelessness, and social vulnerabilities that co-occur and test how the co-occurrence of these factors are associated with no prenatal care and CS incidents among pregnant women diagnosed with syphilis. The research aims will be accomplished by conducting spatial- temporal trend analysis and advanced statistics such as structural equation modeling and cross-legged panel modeling. Quantitative data will come from STD surveillance system and sample size will be determined by the number of women at reproductive age diagnosed with syphilis (N=6,014) and infants born with syphilis (N=426) in Los Angeles County between 2011 and 2020. Findings from the proposed research will position the candidate to propose a F32 or K01 proposal to pilot test a theoretically-driven, mixed methods intervention that addresses the multiplicity of risks among meth using women in the context of STDs and access to reproductive health.

项目概要/摘要 博士前个人国家研究服务奖（F31）的目的是为候选人提供 具有指导和研究经验，将促进候选人作为独立的发展 研究人员，特别注重时空趋势和纵向分析以及多层次 梅毒诊断人群的孕产妇和儿童健康模型 培训的目标是。 发展知识和技能，以：1）使用最先进的方法获得研究经验 纵向监测数据集并以第一作者身份发表研究成果； 流行病学培训侧重于药物滥用和性行为的流行病学知识 传播感染并获得调解和纵向分析的统计技能；以及 3) 获得以下技能： 成功的学术生涯和专业发展，包括道德、研究传播 调查结果以及科学合作关系的发展 培训活动将包括教学。 课程作业和特定研讨会、定向阅读和导师一对一辅导以及指导 候选人将接受培训委员会的指导。 由物质使用、孕产妇和儿童健康、性行为等领域的全国知名专家组成 传播疾病（STD）以及加州大学洛杉矶分校的纵向数据分析。 拟议研究的具体目标是：1) 测量甲基苯丙胺（冰毒）的时空趋势 育龄妇女（15-44岁）、孕妇、先天性妇女的使用发生率 2011 年至 2020 年间在洛杉矶县被诊断患有梅毒的梅毒 (CS) 病例母亲； 确定产前护理就诊、怀孕期间梅毒治疗和分娩的时间趋势是否 被诊断患有梅毒的孕妇中患有 CS 的婴儿因冰毒使用情况而异；3) apply 综合征； 检验冰毒使用、高风险性行为、无家可归和同时发生的社会脆弱性的理论 并测试这些因素的同时出现与无产前护理和 CS 事件之间的关系 被诊断患有梅毒的孕妇将通过进行空间研究来实现。 时间趋势分析和高级统计，例如结构方程建模和盘腿面板 定量数据将来自 STD 监测系统，样本量将由 被诊断患有梅毒的育龄妇女人数 (N=6,014) 和出生时患有梅毒的婴儿人数 (N=426) 2011 年至 2020 年间在洛杉矶县进行的研究。拟议研究的结果将定位 候选人提出 F32 或 K01 提案来试点测试理论驱动的混合方法干预措施 解决使用冰毒的妇女在性传播疾病和获得生殖服务方面面临的多重风险 健康。