The imprinted Dlk1 gene in development and metabolism: a model for epigenetic control of developmental programming

发育和代谢中的印记 Dlk1 基因：发育编程的表观遗传控制模型

• 批准号: G0701196/1
• 负责人: Anne Ferguson-Smith
• 金额: $ 72.4万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701196%2F1
• 关键词: imprinted; Dlk1; gene; development; metabolism

Metabolic diseases are growing in world-wide prevalence; for example, over 1 million people died of diabetes in 2005. This figure is estimated to rise by 50% in the next ten years. Obesity is the most critical factor in the emergence of metabolic diseases; this too is growing in prevalence, particularly in the Western world. The pancreas is a key organ in the regulation of metabolism because it regulates how our bodies convert sugar into energy. Understanding the molecular mechanisms linking the abnormal development and function of the pancreas with metabolic disease, will help us understand this major health problem and contribute to improvements in disease prevention and the development of treatment strategies, in addition to contributing to our basic understanding of networks linking developmental and physiological processes.

代谢疾病在全球流行率上正在增长；例如，2005年，超过100万人死于糖尿病。据估计，在未来十年中，这一数字将增长50％。肥胖是代谢疾病出现的最关键因素。这在流行率上也在增长，尤其是在西方世界。胰腺是调节代谢的关键器官，因为它调节了我们的身体如何将糖转化为能量。了解将胰腺异常发育和功能与代谢疾病联系起来的分子机制，将有助于我们理解这一主要健康问题，并有助于改善疾病预防和治疗策略的发展，除了有助于我们对连接发展和生理过程的网络的基本理解之外。