fMRI of choice and Response Impulsivity in CD

CD 中选择的功能磁共振成像和反应冲动

• 批准号: 7797225
• 负责人: Marc N Potenza
• 金额: $ 11.44万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797225
• 关键词: Alcohol or Other Drugs use; Anterior; Binding; Brain; Clinical; Cocaine; Cocaine Dependence; Color; Complex; Corpus striatum structure; Data; Development; Disease; Dopamine; Dorsal; Drug Addiction; Education; Etiology; Event; Exposure to; Functional Magnetic Resonance Imaging; Gender; Human; Impulsivity; Incentives; Individual; Individual Differences; Investigation; Link; Literature; Measures; Methylphenidate; Neurobiology; Neurocognitive; Outcome Study; Patient Self-Report; Performance; Pharmaceutical Preparations; Phenotype; Positron-Emission Tomography; Prevention; Process; Public Health; Publishing; Research; Rewards; Sampling; Self Administration; Signal Transduction; Task Performances; Treatment outcome; Ventral Striatum; Wit; addiction; base; behavior measurement; cingulate cortex; clinically relevant; cocaine use; cognitive control; improved; prevent; receptor function; relating to nervous system; response; reward processing; treatment strategy

Cocaine addiction respresents a devastating human condition. The complexities of drug addictions have slowed the development of effective prevention and treatment strategies. Impulsivity is an important construct that has been linked to the vulnerability to addictive processes. Additionally, the exposure to addictive drugs has been associated with increased impulsivity. However, the relationhip between impulsivity and addiction appears complex and pooriy understood, partially because of the complexity of impulsivity. Impulsivity has been found to factor into two main domains (choice and response) that appear associated with different aspects of drug addiction. However, the neurobiological substrates of these forms of impulsivity in drug addiction are not well understood. We propose investigating in individuals with and without cocaine dependence the neural substrates of choice and response impulsivity using functional magnetic resonance imaging (fMRI), with specific paradigms assessing each domain. Additionally, we will collect fMRI data to assess cognitive control and reward processing in the same subjects. Subjects in this project will also participate in project 2 assessing striatal dopamine D2/D3 receptor function and in the Clinical and Educational Core in which a comprehensive battery of clinical and neurcognitive measures will be obtained. This information will include information on stimulant influences on choice and response impulsivity and (amongst the cocaine dependent subjects) cocaine self administration. By integrating information across studies, a more complete understanding of the brain function underiying impulsivity as it relates to cocaine addiction will be achieved. Such information has significant potential to inform investigations into more effective prevention and treatment strategies for cocaine addiction.

可卡因成瘾者是一种毁灭性的人类状况。吸毒成瘾的复杂性减慢了有效的预防和治疗策略的发展。冲动是一个重要的结构，与上瘾过程的脆弱性有关。此外，对成瘾性药物的暴露与冲动性的增加有关。但是，冲动性和成瘾之间的关系似乎是复杂而贫穷的，部分原因是冲动的复杂性。 已经发现冲动性将与药物成瘾的不同方面相关的两个主要领域（选择和反应）。然而，这些冲动性成瘾中这些形式的神经生物学底物尚不清楚。我们建议使用有或没有可卡因依赖性的个体进行研究，使用功能性磁共振成像（fMRI）的选择和反应冲动性的神经底物，而特定的范式评估了每个域。此外，我们会的 收集fMRI数据以评估同一受试者中的认知控制和奖励处理。该项目中的受试者还将参加评估纹状体多巴胺D2/D3受体功能的项目2，以及将获得一系列临床和神经认知措施的临床和教育核心。该信息将包括有关兴奋性影响和响应的影响的信息 冲动性和（在可卡因依赖性主题中）可卡因自我管理。通过整合跨研究的信息，将对与可卡因成瘾相关的脑功能不足的脑功能进行更完整的了解。此类信息具有重要的潜力，可以为可卡因成瘾的更有效的预防和治疗策略提供信息。