Consequences of Adolescent Alcohol Use on Brain Development

青少年饮酒对大脑发育的影响

• 批准号: 9064026
• 负责人: MARISA M SILVERI
• 金额: $ 56.19万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-05 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9064026
• 关键词: Adolescent; Adolescent Medicine; Age; Age of Onset; Alcohol consumption; Alcohol or Other Drugs use; Anisotropy; Anterior; Behavior assessment; Boston; Brain; Clinic; Clinical; Clinical assessments; Cognitive; Core-Binding Factor; Data; Development; Diffusion Magnetic Resonance Imaging; Drug usage; Enrollment; Failure; Female; Female Adolescents; Foundations; Functional Magnetic Resonance Imaging; Glutamates; Health; Hippocampus (Brain); Hyperactive behavior; Image; Imaging Techniques; Machine Learning; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male Adolescents; Measurement; Measures; Medial; Mediating; Memory; Modeling; Multimodal Imaging; Neuronal Plasticity; New England; Outcome; Pattern; Pediatric Hospitals; Performance; Perfusion; Preventive Intervention; Primary Health Care; Process; Recruitment Activity; Research; Rest; Sampling; Signal Transduction; Spin Labels; Substance abuse problem; Task Performances; Temporal Lobe; Time; Visit; adolescent alcohol; adolescent brain development; adolescent substance abuse; age related; alcohol and other drug; alcohol use initiation; base; blood oxygen level dependent; cingulate cortex; critical period; design; early alcohol use; follow-up; gamma-Aminobutyric Acid; improved; innovation; insight; learning strategy; male; myelination; neuroimaging; neuropsychological; pediatrician; practice-based research network; reduce adolescent alcohol; relating to nervous system; response; sex; spatial memory; underage drinking; way finding; white matter

DESCRIPTION (provided by applicant): This revised R01 A1 proposal (AA022493), "Consequences of Adolescent Alcohol Use on Brain Development", responds to the need to understand the impact of initiating alcohol consumption on adolescent brain maturation. We have teamed with the Center for Adolescent Substance Abuse Research (CeASAR) and Boston Children's Hospital to implement an innovative strategy that combines multiple neuroimaging and neuropsychological approaches to identify neurodevelopmental vulnerabilities associated with early and escalating alcohol use during adolescence. Adolescents will be recruited from general pediatrician offices and adolescent medicine clinics comprising the New England Partnership for Substance Abuse Research (NEPSAR), a practice-based research network of primary care offices. Adolescents will be enrolled into the study prior to the initiation of alcoho use or other drug use, and examined longitudinally, at baseline (13-14 yrs old) and again at two annual follow-up visits. To provide a comprehensive longitudinal profile of brain function, structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and task and resting state blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) will be paired with magnetic resonance spectroscopy (MRS) to measure GABA and glutamate levels in the anterior cingulate cortex (ACC) and medial temporal lobe (MTL, containing hippocampus). In addition, arterial spin labeling (ASL) will be used to measure quantitative perfusion, which will be used to calibrate the magnitude of BOLD fMRI signal changes during response inhibition and spatial memory fMRI tasks. Magnetic resonance measures will be integrated with measures from clinical assessments and an extensive neuropsychological battery, designed to detect and further characterize developmental changes and the influence of adolescent alcohol use. The incorporation of complementary multi-modal measures of brain function and neuroplasticity could offer valuable insight into the dynamic processes of brain maturation and help identify neural signatures associated with the onset and escalation of alcohol use, which will provide a foundation for informing prevention and intervention efforts aimed at reducing adolescent alcohol consumption.

描述（由申请人提供）：修订后的R01 A1提案（AA022493），“青少年饮酒对脑发育的后果”，对了解启动酒精消费对青少年大脑成熟的影响的需求做出了回应。我们与青少年药物滥用研究中心（Ceasar）和波士顿儿童医院合作，实施了一种创新策略，该策略结合了多种神经影像学和神经心理学方法，以识别与早期和升级酒精使用相关的神经发育脆弱性。青少年将从一般儿科医生办公室和青少年医学诊所招募，包括新英格兰的药物滥用研究合作伙伴关系（NEPSAR），这是基于实践的初级保健办公室研究网络。在启动酒精使用或其他药物使用之前，将招募青少年，并在基线（13-14岁）进行纵向检查，并在两次年度随访中再次进行。为了提供大脑功能的全面纵向曲线，结构磁共振成像（MRI），扩散张量成像（DTI）以及任务和静止状态血氧水平依赖（BOLD）功能磁共振成像（FMRI）将与磁共振配对光谱（MRS）测量前扣带回皮层（ACC）和内侧颞叶（MTL，含有海马）中的GABA和谷氨酸水平。此外，动脉自旋标记（ASL）将用于测量定量灌注，该灌注将用于校准大胆fMRI信号在响应抑制和空间记忆fMRI fMRI任务期间的大小。磁共振措施将与临床评估的措施和广泛的神经心理电池进行集成，旨在检测和进一步表征发展变化和青少年饮酒的影响。融合脑功能和神经塑性的互补多模式测量方法可以为大脑成熟的动态过程提供宝贵的见解，并有助于确定与酒精使用的发作和升级有关的神经特征，这将为预防和干预工作提供基础旨在减少青少年饮酒。