Mentoring in Patient-Oriented Neuroscience Research

以患者为导向的神经科学研究的指导

基本信息

批准号：
10525537
负责人：
MARISA M SILVERI
金额：
$ 16.28万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-08 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10525537
关键词：
Address Adolescent Adult Alcohol abuse Alcohol consumption Alcohols Ancillary Study Anxiety Anxiety Disorders Applications Grants Area Award Big Data Boston Brain COVID-19 pandemic Child Abuse and Neglect Child Traumatic Stress Clinical Clinical Research Collaborations Cultural Diversity Data Data Analyses Development Development Plans Diagnosis Disadvantaged Doctor of Philosophy Education Environment Exposure to Faculty Fostering Foundations Funding Future Gender Gender Identity Goals Grant Group Therapy Hospitals Hour Human Individual Inequality Interdisciplinary Study Intervention Intervention Studies Interview Knowledge Laboratories Longevity Mental Depression Mental Health Mental disorders Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Minority Groups Monitor Mood Disorders NCI Scholars Program National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Neurobiology Neurocognitive Neurosciences Research Paper Patients Peer Review Peer Review Grants Peptides Population Population Study Preparation Prevention Principal Investigator Psychiatry Psychopathology Public Health Publications Publishing Recovery Regimen Research Research Personnel Residencies Resources Risk Role SECTM1 gene Sexual and Gender Minorities Site Stress Time Training Underrepresented Minority United States National Institutes of Health Vulnerable Populations Women&apos s Health Work Yoga Youth addiction adolescent brain development alcohol misuse alcohol research alcohol risk alcohol use disorder career career development child depression childhood anxiety comorbidity depressive symptoms effective therapy emerging adult ethnic disadvantage ethnic diversity experience health disparity inner city lectures medical schools meetings mid-career faculty minority children minority trainee neurodevelopment neuroimaging next generation outreach patient oriented patient oriented research patient population pre-clinical programs racial and ethnic racial diversity skills stem substance use success transgender underage drinking undergraduate student vulnerable adolescent

项目摘要

PROJECT SUMMARY I am a clinical researcher and Director of the Neurodevelopmental Laboratory on Addictions and Mental Health at McLean Hospital. I also am an Associate Professor in Psychiatry at Harvard Medical School. I have been continuously funded as a principal investigator (PI) to conduct NIAAA-sponsored patient-oriented research (POR) since 2004 and have been a collaborator and consultant on multiple NIH-sponsored grants. My research focusing on understanding adolescent brain development, and risk for and underlying neurobiology of addiction and psychiatric disorders. During the first 5-year K24 period, I provided mentoring to 50 individuals ranging in rank from undergraduates through psychiatry residents and junior faculty. These mentees have made notable success, including publishing papers, submitting grant applications and being promoted. I work in a rich environment for clinical research, which is ideal for providing mentoring in POR. As I receive no institutional support for mentoring and will be required to curtail mentoring efforts to assume significant non- research responsibilities, a K24 renewal will continue to provide protected time that would allow me to maintain and increase my intensive mentorship to trainees, and attract new research mentees to POR. My immediate and long-term career objectives are to continue characterizing neurobiological markers in addiction and psychiatric disorders, which will inform the development of new and effective treatments for alcohol use disorders and for individuals with dual diagnoses, and to train the next generation of investigators to develop the skills they require to effectively conduct POR. I remain committed to disseminating research findings (through publications, scientific lectures and public outreach) and provide mentoring to trainees in public outreach, the goal of which is to provide education around alcohol research, which in turn will help prevention efforts and inform treatment interventions, to aid in the reduction of suffering due to alcohol use and abuse. The specific aims to be accomplished during the period of the award are to 1) provide substantive mentoring of junior investigators and trainees in POR (35%), with a focus on mentoring underrepresented minority trainees; 2) continue and extend involvement in my POR (10%), and 3) advance my expertise in the content areas of adolescent comorbid psychopathology, clinical approaches in adolescent treatment, and conducting research in vulnerable adolescent and adult populations, including racial/ethnically disadvantaged youth and those navigating gender identity development, both with established evidence of mental health disparities (5%). Despite the challenges imposed by the COVID19 pandemic, these mentoring relationships have continued to grow, and trainees are making significant strides in their paths toward POR. I remain deeply committed to the continued training of a remarkable group of mentees, who are the future of addiction and psychiatry POR. Through intensive mentoring I will enhance my POR by increasing my clinical perspectives, and by incorporating treatment and multicultural considerations into my POR initiatives.

项目概要我是成瘾和心理健康神经发育实验室的临床研究员和主任在麦克莱恩医院。我也是哈佛医学院精神病学副教授。我曾经作为首席研究员 (PI) 持续资助开展 NIAAA 资助的以患者为导向的研究自 2004 年起担任 POR（POR），并一直是 NIH 资助的多项资助的合作者和顾问。我的研究重点是了解青少年大脑发育以及青少年大脑发育的风险和潜在的神经生物学成瘾和精神疾病。在第一个 5 年 K24 期间，我为 50 个人提供了指导级别从本科生到精神病学住院医师和初级教员。这些受训者有取得了显着的成功，包括发表论文、提交资助申请和晋升。我的工作丰富的临床研究环境，非常适合提供 POR 指导。因为我没有收到为指导提供机构支持，并将需要减少指导工作以承担重大的非研究职责，K24 续订将继续提供受保护的时间，使我能够维持加强对学员的强化指导，并吸引新的研究学员加入 POR。我的即时长期职业目标是继续表征成瘾和成瘾中的神经生物学标记物精神疾病，这将为开发新的有效的酒精治疗方法提供信息疾病和具有双重诊断的个体，并培训下一代研究人员开发有效进行 POR 所需的技能。我仍然致力于传播研究成果（通过出版物、科学讲座和公共宣传）并为受训者提供公共指导外展活动，其目标是提供有关酒精研究的教育，这反过来又有助于预防努力并为治疗干预措施提供信息，以帮助减少因酗酒和滥用造成的痛苦。奖励期间要实现的具体目标是： 1) 提供实质性指导 POR 中的初级调查员和实习生（35%），重点是指导代表性不足的少数族裔实习生； 2) 继续并扩大参与我的 POR (10%)，以及 3) 提升我在以下内容领域的专业知识青少年共病精神病理学、青少年治疗的临床方法以及开展研究弱势青少年和成人群体，包括种族/民族弱势青年和那些引导性别认同的发展，两者都有明确的心理健康差异证据（5%）。尽管面临新冠病毒大流行带来的挑战，这些指导关系仍在继续成长，学员在 POR 的道路上取得了重大进展。我仍然坚定地致力于继续培训一群杰出的学员，他们是成瘾和精神病学 POR 的未来。通过强化指导，我将通过增加我的临床视角来增强我的 POR，并通过将治疗和多元文化考虑纳入我的 POR 计划中。