Mentoring in Patient-Oriented Neuroscience Research

以患者为导向的神经科学研究的指导

基本信息

批准号：
9757593
负责人：
MARISA M SILVERI
金额：
$ 15.13万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-08 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9757593
关键词：
Abstinence Adolescent Alcohol abuse Alcohol consumption Anxiety Applications Grants Area Award Child Abuse and Neglect Clinical Clinical Research Collaborations Comorbidity Data Set Development Development Plans Doctor of Philosophy Environment Epigenetic Process Faculty Foundations Funding Future Goals Grant Hospitals Intervention Laboratories Mental Health Mental disorders Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Monitor National Center for Complementary and Alternative Medicine National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Neurobiology Neurosciences Research Patients Prevention Principal Investigator Psychiatry Psychopathology Public Health Publications Research Research Personnel Risk Time Training Trust United States National Institutes of Health Work addiction adolescent brain development adolescent patient alcohol use disorder binge drinker career career development dual diagnosis effective therapy emerging adult interest lectures medical schools mid-career faculty next generation outreach patient oriented patient oriented research patient population programs secondary analysis skills

项目摘要

PROJECT SUMMARY I am a clinical researcher and Director of the Neurodevelopmental Laboratory on Addictions and Mental Health at McLean Hospital. I also am an Associate Professor in Psychiatry at Harvard Medical School. I have been continuously funded as a principal investigator (PI) to conduct NIAAA-sponsored patient-oriented research (POR) since 2004 and have been a collaborator and consultant on several additional NIH-sponsored grants. My research has focused on understanding adolescent brain development, and risk for and underlying neurobiology of addiction and psychiatric disorders. I currently serve as PI on one NIAAA R01 grant and one Foundation grant, and am Co-Investigator on 3 R01s (NIMH, NCCAM, NIDA) and 1 R21 (NIAAA). I mentor a growing group of junior investigators, including 3 mentees on K01 grants. I work in a rich environment for clinical research, which is ideal for training junior faculty in POR. However, I receive no institutional support for mentoring and will be required to curtail mentoring efforts to assume significant non-research responsibilities beginning in 2017. The K24 award will protect time that would permit an increase in intensive mentorship to junior investigators and attract researchers to POR. My immediate and long-term career objectives are to characterize neurobiological markers in addiction and psychiatric disorders, which will inform the development of new and effective treatments for alcohol use disorders and for patients with dual diagnoses, and to train the next generation of investigators to develop the skills they require to effectively conduct POR. I also remain committed to disseminating research findings (through publications, scientific lectures and public outreach) that will help prevention efforts and that will inform treatment interventions, to aid in the reduction of suffering due to alcohol use and abuse. The specific aims to be accomplished during the period of the award are to 1) provide substantive mentoring of junior investigators in POR (35%), 2) continue and extend involvement in my POR (10%), and 3) develop specific new content expertise in the areas of adolescent comorbid psychopathology, clinical approaches in adolescent treatment settings, and epigenetics (5%). I am committed to training a remarkable group of mentees, who are the future of addiction and psychiatry POR. Through intensive mentoring I will, in turn, enhance my POR by increasing my clinical perspectives, and by incorporating treatment and epigenetic components into new POR initiatives.

项目摘要我是成瘾和心理健康神经发育实验室的临床研究员和主任在麦克莱恩医院。我也是哈佛医学院精神病学副教授。我去过不断作为首席研究员（PI）进行持续资助，以进行NIAAA赞助的以患者为导向的研究（POR）自2004年以来，一直是其他NIH赞助的赠款的合作者和顾问。我的研究重点是了解青少年的大脑发展，以及对基础的风险成瘾和精神疾病的神经生物学。我目前在一项NIAAA R01赠款中担任PI和一项 Foundation Grant和3 R01（NIMH，NCCAM，NIDA）和1 R21（NIAAA）的AM共同投资者。我指导A。成长中的初级调查人员，其中包括3名对K01赠款的受训者。我在一个丰富的环境中工作临床研究是POR培训初级教师的理想选择。但是，我没有得到机构的支持指导，并将被要求减少指导努力，以承担重大的非研究职责从2017年开始。K24奖将保护时间，这将允许增加密集指导的时间初级研究人员并吸引研究人员加入POR。我的直接和长期职业目标是在成瘾和精神疾病中表征神经生物学标志物，这将为发展提供信息针对酒精使用障碍的新有效治疗方法以及有双重诊断的患者，并训练下一代研究人员开发有效进行POR所需的技能。我也留下来致力于传播研究结果（通过出版物，科学讲座和公开展览）将有助于预防努力，这将为治疗干预提供信息，以帮助减少痛苦饮酒和滥用。在奖励期间要完成的具体目标是1）在POR中对初级研究人员进行实质性指导（35％），2）继续并扩展我的POR参与（10％）和3）在青少年合并症心理病理学领域发展特定的新内容专业知识，青少年治疗环境和表观遗传学的临床方法（5％）。我致力于培训杰出的受训者，他们是成瘾和精神病学的未来。通过密集指导我将通过增加临床观点并结合起来来增强我的POR 治疗和表观遗传成分中的新计划。