Cortical subcortical reorganization and risk behaviors of early alcohol use initiation

皮质下皮质重组和早期饮酒开始的风险行为

• 批准号: 10665741
• 负责人: Marc N Potenza
• 金额: $ 34.44万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-25 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665741
• 关键词: Address; Adolescence; Adolescent; Age; Alcohol abuse; Alcohol consumption; Alcohols; Anatomy; Area; Behavior; Behavioral; Big Data; Brain; Brain Stem; Brain region; Characteristics; Child; Childhood; Cognitive; Data; Data Science; Development; Early Diagnosis; Early Intervention; Exhibits; Female; Future; Gender; Growth and Development function; Health Care Costs; Impaired cognition; Individual; Intervention; Joints; Knowledge; Link; Literature; Longitudinal Studies; Machine Learning; Marijuana; Measures; Methodology; Methods; Modeling; Neurobiology; Neurosciences; Pattern; Phenotype; Prefrontal Cortex; Problem behavior; Psychiatry; Public Health; Reporting; Research Design; Rest; Risk; Risk Behaviors; Role; Running; Sleep; Sleep Disorders; Sleep disturbances; Substance Use Disorder; Surface; Testing; Thalamic structure; Time; Tobacco; Trees; United States National Institutes of Health; addiction; adolescent alcohol and drug use; advanced analytics; alcohol use initiation; boys; brain circuitry; cognitive development; cognitive function; cognitive performance; connectome; design; early adolescence; early alcohol use; executive function; externalizing behavior; follow-up; girls; gray matter; innovation; insight; joint loading; male; neural; neurobiological mechanism; neuromechanism; novel; prevent; prospective; structural imaging; substance use; underage drinking; young adult

Project Summary/Abstract Early initiation of alcohol use (EIAU) during adolescence is a key contributor to development of lifetime alcohol (AUD) and/or substance use disorders (SUDs). A critical component for preventing and intervening EIAU is early detection using behavioral or cognitive risk precursors; and understanding better their underlying neural substrates before the onset of substance use may aid in developing more effective and targeted interventions. Prior studies suggest sleep disturbance, internalizing behaviors, externalizing behaviors, and cognitive performance are potential risk precursors of EIAU. However, mixed or inconsistent findings have been reported which may reflect study design and methodological issues, and the neural substrates subserving co- development of these frequently occurring problems remain to be identified. In this application, we propose to use data from the longitudinal Adolescent Brain Cognitive Development (ABCD) study to investigate the neural substrates that are predictive of EIAU and its risk precursors. A number of advanced analytical approaches will be used to extract novel features at both structural and functional levels. For example, the Joint and Individual Variance Explained (JIVE) method will be used to extract biologically meaningful cortical-subcortical covariation patterns. Existing literature and our preliminary results led us to hypothesize that the cortical-subcortical covariation pattern including brainstem, thalamus, prefrontal cortex and other regions underlies the co- development of sleep, internalizing behaviors, externalizing behaviors, and poor cognitive function from late childhood to mid-adolescence. Specifically, this project has three complementary aims. Aim 1 will assess the relationships between the baseline cortical-subcortical covariation patterns and EIAU and its four risk precursors in mid-adolescence. Aim 2 will characterize the developmental trajectory of cortical-subcortical covariation pattern and assess its dynamic relationship with the four risk precursors longitudinally. Aim 3 will explore whether functional connectivity predicts sleep disturbance, cognitive performance, behavioral problems, and/or age at first alcohol use. Results from this application will significantly advance the field of addiction neuroscience.

项目概要/摘要 青春期早期开始饮酒（EIAU）是终生酗酒的关键因素 （AUD）和/或物质使用障碍（SUD）。预防和干预 EIAU 的一个关键因素是及早 使用行为或认知风险前兆进行检测；并更好地理解他们的潜在神经 物质使用开始前的基质可能有助于制定更有效和有针对性的干预措施。 先前的研究表明睡眠障碍、内化行为、外化行为和认知 绩效是 EIAU 的潜在风险前兆。然而，报告的结果混合或不一致 这可能反映了研究设计和方法学问题，以及支持共同的神经基质 这些经常发生的问题的发展仍有待确定。在本申请中，我们建议 使用纵向青少年大脑认知发展（ABCD）研究的数据来调查神经 预测 EIAU 及其风险前兆的底物。许多先进的分析方法将 用于在结构和功能层面提取新特征。例如，联合和个人 方差解释（JIVE）方法将用于提取具有生物学意义的皮质-皮质下协变 模式。现有文献和我们的初步结果使我们假设皮质-皮质下 包括脑干、丘脑、前额叶皮层和其他区域在内的共变模式是共变的基础 睡眠发育、内化行为、外化行为以及晚期认知功能较差 童年至青春期中期。具体来说，该项目具有三个互补的目标。目标 1 将评估 基线皮质-皮质下协变模式与 EIAU 及其四种风险前兆之间的关系 在青春期中期。目标 2 将描述皮质-皮质下协变的发展轨迹 纵向分析其与四种风险前兆的动态关系。目标 3 将探讨是否 功能连接可预测睡眠障碍、认知表现、行为问题和/或年龄 首次饮酒。该应用的结果将显着推进成瘾神经科学领域的发展。

项目成果

Brain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort.

• DOI: 10.1556/2006.2023.00006
• 发表时间: 2023-03-30
• 期刊: JOURNAL OF BEHAVIORAL ADDICTIONS
• 影响因子: 7.8
• 作者: Zhao, Yihong;Paulus, Martin P.;Potenza, Marc N.
• 通讯作者: Potenza, Marc N.

Behavioral addictions in the ICD-11: An important debate that is anticipated to continue for some time.

• DOI: 10.1556/2006.2023.00042
• 发表时间: 2023-10-05
• 期刊: JOURNAL OF BEHAVIORAL ADDICTIONS
• 影响因子: 7.8
• 作者: Brand, Matthias;Potenza, Marc N.
• 通讯作者: Potenza, Marc N.

Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders.

• DOI: 10.1080/19585969.2023.2242359
• 发表时间: 2023-12
• 期刊: Dialogues in clinical neuroscience
• 影响因子: 8.3