Sub Clinical Cardiovascular Disease in Youth (SEARCH CVD)

青少年亚临床心血管疾病 (SEARCH CVD)

基本信息

批准号：
7935192
负责人：
Dana Dabelea
金额：
$ 74.03万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-22 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7935192
关键词：
Address Adolescence Adolescent Adult Adverse event Affect African American Age Albumins Albuminuria Ancillary Study Anthropometry Apolipoproteins B Arts Behavioral Blood Glucose Blood Vessels C-reactive protein Cardiac Cardiovascular Abnormalities Cardiovascular Diseases Cardiovascular system Caring Carotid Atherosclerotic Disease Central obesity Child Childhood Chronic Chronic Disease Clinical Collaborations Colorado Complications of Diabetes Mellitus Control Groups Data Data Collection Development Diabetes Mellitus Diet Disease Disease Outcome Disease Progression Dyslipidemias Elderly Electron Beam Tomography Epidemiology Ethnic Origin European Evaluation Excretory function Exposure to Fatty acid glycerol esters Fibrinogen Functional disorder Funding Glycosylated hemoglobin A Goals Heart Hypertrophy High Density Lipoprotein Cholesterol Hispanics Hyperglycemia Hypertension IL6 gene Incidence Individual Inflammation Inflammatory Insulin Insulin Resistance Insulin-Dependent Diabetes Mellitus Intake Left Ventricular Mass Literature Location Low-Density Lipoproteins Measurement Measures Medial Mental Depression Metabolic Methods Morbidity - disease rate Natural History Newly Diagnosed Not Hispanic or Latino Obesity Observational Study Ohio Outcome Pathway interactions Patients Peripheral Physical activity Physiologic pulse Pilot Projects Plasma Population Population Heterogeneity Process Public Health Quality of life Race Recruitment Activity Registries Reporting Research Research Design Research Infrastructure Research Personnel Risk Risk Factors Role Screening procedure Site Smoking Staging Structure Testing Thick Triglycerides Ultrasonography United States Vascular Diseases Weight Gain Work Youth adiponectin advanced disease aged arterial stiffness calcification cardiovascular disorder risk case control cigarette smoking cohort coronary artery calcification cost cytokine depressive symptoms design experience fasting glucose follow-up health related quality of life indexing insight longitudinal design modifiable risk mortality non-diabetic particle population based pre-clinical premature premature atherosclerosis prevent prospective public health relevance saturated fat sex systematic review tonometry urinary young adult

项目摘要

DESCRIPTION (provided by applicant): Type 1 Diabetes mellitus (T1D) is one of the leading chronic diseases of childhood, affecting 1.54 per 1,000 youth in the United States. Despite the increasing body of evidence indicating the importance of premature atherosclerosis as a major contributor to increased morbidity and mortality in patients with T1D, the risk factors for premature CVD and the progression from preclinical to advanced disease have not been studied systematically. The overall goal of this proposal is to understand the contribution of metabolic, behavioral and diabetes-specific risk factors to the development of cardiovascular sub-clinical abnormalities in adolescents and young adults with T1D, as compared to non-diabetic controls. The proposed work is an ancillary study to the CDC/DDT and NIH/NIDDK funded SEARCH for Diabetes in Youth project, The current proposal (SEARCH CVD) will integrate all relevant information provided by SEARCH, will recruit non-diabetic controls, and will collect data on CVD sub-clinical outcomes among 800 10-25 year old adolescents and young adults from Colorado and Ohio. Using case-control and within case longitudinal designs, SEARCH CVD will address specific hypotheses related to the presence of, and risk factors for, preclinical CVD in youth with and without T1D. The specific aims of this proposal are: Aim 1: To describe the presence and determinants of sub-clinical abnormalities in cardiovascular (CVD) structure and function among 400 adolescents and young adults with T1D and 400 non-diabetic controls. a. Structure: increased left ventricular mass (LV mass), increased carotid intimal-medial thickness (cIMT) b. Function: decreased cardiac function, increased arterial stiffness and endothelial dysfunction Aim 2: To explore the 6-year rate of change and risk factors for changes in pulse wave velocity, augmentation index and brachial distensibility in youth with T1D and prior measures of arterial stiffness. Diabetes-specific, metabolic and behavioral risk factors will be explored. Public Health Relevance: Little is known about the development and progression of preclinical CVD in young patients with T1D. If the progression is similar to that in adults, there is a major public health concern in that they may experience adverse CVD outcomes as early as their late 20's to early 30's. This study will advance our understanding of the natural history of early CVD in youth, and will provide insights into the mechanisms from which strategies to prevent or limit vascular disease in individuals with T1D can be developed.

描述（由申请人提供）： 1 型糖尿病 (T1D) 是儿童期的主要慢性疾病之一，在美国每 1,000 名青少年中就有 1.54 人患有这种疾病。尽管越来越多的证据表明过早动脉粥样硬化是导致 T1D 患者发病率和死亡率增加的一个主要因素，但过早 CVD 的危险因素以及从临床前到晚期疾病的进展尚未得到系统研究。该提案的总体目标是了解与非糖尿病对照组相比，代谢、行为和糖尿病特异性危险因素对患有 T1D 的青少年和年轻人心血管亚临床异常的发展的贡献。拟议的工作是 CDC/DDT 和 NIH/NIDDK 资助的 SEARCH for Diabetes in Youth 项目的辅助研究，当前提案 (SEARCH CVD) 将整合 SEARCH 提供的所有相关信息，将招募非糖尿病对照，并收集来自科罗拉多州和俄亥俄州的 800 名 10-25 岁青少年和年轻人的 CVD 亚临床结果数据。使用病例对照和病例纵向设计，SEARCH CVD 将解决与患有和不患有 T1D 的青少年临床前 CVD 的存在及其危险因素相关的具体假设。该提案的具体目标是：目标 1：描述 400 名患有 T1D 的青少年和年轻人以及 400 名非糖尿病对照者中心血管 (CVD) 结构和功能亚临床异常的存在及其决定因素。一个。结构：左心室质量（LV 质量）增加，颈动脉内膜中层厚度（cIMT）增加 b．功能：心脏功能下降、动脉僵硬度增加和内皮功能障碍目标 2：探讨 1 型糖尿病青年患者脉搏波速度、增强指数和肱动脉扩张度的 6 年变化率和危险因素以及先前的动脉僵硬度测量结果。将探讨糖尿病特有的代谢和行为风险因素。公共卫生相关性：对于年轻 T1D 患者临床前 CVD 的发生和进展知之甚少。如果病情进展与成人相似，则存在重大公共卫生问题，因为他们可能早在 20 岁末至 30 岁出头就出现不良的 CVD 结果。这项研究将增进我们对青少年早期 CVD 自然史的理解，并将提供对机制的见解，从而制定预防或限制 T1D 患者血管疾病的策略。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Reduced heart rate variability among youth with type 1 diabetes: the SEARCH CVD study.

DOI：
10.2337/dc12-0463
发表时间：
2013-01
期刊：
Diabetes care
影响因子：
16.2
作者：
Jaiswal M;Urbina EM;Wadwa RP;Talton JW;D'Agostino RB Jr;Hamman RF;Fingerlin TE;Daniels S;Marcovina SM;Dolan LM;Dabelea D
通讯作者：
Dabelea D

Cardiovascular risk factors are associated with increased arterial stiffness in youth with type 1 diabetes: the SEARCH CVD study.

DOI：
10.2337/dc13-0851
发表时间：
2013-12
期刊：
Diabetes care
影响因子：
16.2
作者：
Dabelea D;Talton JW;D'Agostino R Jr;Wadwa RP;Urbina EM;Dolan LM;Daniels SR;Marcovina SM;Hamman RF
通讯作者：
Hamman RF