Multidisciplinary Training in Brain Disorders and Development

脑部疾病和发育的多学科培训

• 批准号: 7232984
• 负责人: John William Swann
• 金额: $ 9.61万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7232984
• 关键词: Brain Diseases; Development; Training; multidisciplinary

DESCRIPTION (provided by applicant): The goal of this postdoctoral training program is to train young scientists, particularly physician scientists, and promote careers focused on understating and developing treatments for developmental brain disorders. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 21 training faculty have been selected from 5 departments. They include: 3 MDs, 2 MD/PhDs and 16 PhDs. There are: 11 Professors, 4 Associate Professors and 6 Assistant Professors. There are currently 70 postdoctoral students training in laboratories of the faculty and include 10 MD/PhDs, 10 MDs and 50 PhDs. Dr. John Swann will continue to serve as the Program Director and will be responsible for the day-to-day operation of the program. Drs. Huda Zoghbi and Jeff Noebels will continue to serve as co-directors. Major areas of training include the genetic and molecular basis of neurodevelopmental disorders including but not limited to: Rett syndrome, Angelman syndrome, Fragile X syndrome and Autism. Another concentrated area of training is in epilepsy where the molecular bases of the inherited as well as acquired epilepsies are studied. All laboratories employ cutting edge biotechnology to create and study relevant animals models of disease in order to not only understand the biological basis for these disorders but to screen potential new therapies that could lead to clinical trials and eventually enter clinical practice. During the current funding cycle, 10 postdoctoral students have thus far entered our training program and 6 are already faculty members at major universities. These include 3 MD/PhD child neurologists that have been awarded K08 grants and are now pursuing research careers. Three training tracks are offered. One is for MD/PhDs and MDs with substantial research experience. Another is for less experienced MDs where training is more formal and includes laboratory rotations and graduate courses. PhDs receive substantial training in clinical aspects of neurodevelopmental disorders through Dinner Discussions, clinical conferences and subspecialty clinics. Baylor College of Medicine and Texas Children's Hospital have committed substantial resources to the study of the neurobiology of disease and are currently planning the creation of the "Texas Children's Neurological Research Institute" which promises to become a major center for postdoctoral training for generations to come. By training outstanding research scientists, we feel new understandings and treatments for the devastating developmental disorders in infants and young children will emerge.

描述（由申请人提供）：该博士后培训计划的目标是培训年轻科学家，特别是医师科学家，并促进专注于了解和开发发育性脑疾病治疗方法的职业生涯。计划在与神经发育障碍研究相关的科学学科中进行多学科培训。至此，从5个院系中选拔了21名培训教师。其中包括：3名医学博士、2名医学博士/博士和16名博士。现有：教授11人，副教授4人，助理教授6人。学院实验室现有博士后70名，其中博士/博士10名，医学博士10名，博士50名。 John Swann 博士将继续担任项目总监，负责该项目的日常运营。博士。胡达·佐格比 (Huda Zoghbi) 和杰夫·诺贝尔 (Jeff Noebels) 将继续担任联合董事。培训的主要领域包括神经发育障碍的遗传和分子基础，包括但不限于：Rett 综合征、Angelman 综合征、脆性 X 综合征和自闭症。培训的另一个集中领域是癫痫，研究遗传性和获得性癫痫的分子基础。所有实验室均采用尖端生物技术来创建和研究相关疾病动物模型，以便不仅了解这些疾病的生物学基础，而且筛选可能导致临床试验并最终进入临床实践的潜在新疗法。在本轮资助期间，已有10名博士后进入我们的培训项目，其中6名已在各大大学担任教职。其中包括 3 名儿童神经病学博士/博士，他们已获得 K08 资助，目前正在从事研究工作。提供三个训练轨道。一类是针对医学博士/博士和具有丰富研究经验的医学博士。另一种是针对经验不足的医学博士，其培训更为正式，包括实验室轮换和研究生课程。博士通过晚餐讨论、临床会议和亚专科诊所接受神经发育障碍临床方面的大量培训。贝勒医学院和德克萨斯儿童医院投入了大量资源来研究疾病的神经生物学，目前正在计划创建“德克萨斯儿童神经学研究所”，该研究所有望成为未来几代博士后培训的主要中心。通过培训杰出的研究科学家，我们认为对婴幼儿破坏性发育障碍的新理解和治疗将会出现。