Neural Basis of Sign Language from Lesion Mapping

来自病变映射的手语神经基础

• 批准号: 7714000
• 负责人: URSULA BELLUGI
• 金额: $ 34.7万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-14 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714000
• 关键词: Address; Anatomy; Aphasia; Behavioral; Brain; Caring; Case Study; Cereals; Clinical; Communication impairment; Complex; Comprehension; Data; Databases; Goals; Hearing Impaired Persons; Individual; Language; Language Disorders; Lesion; Manuals; Maps; Measures; Methods; Mission; Motor; Names; National Institute on Deafness and Other Communication Disorders; Neurocognitive; Participant; Pattern; Population; Process; Production; Public Health; Research; Sensory; Shapes; Short-Term Memory; Sign Language; Symptoms; Testing; Work; base; deafness; injured; lexical; neuropsychological; programs; public health relevance; relating to nervous system; tool

DESCRIPTION (provided by applicant): Sign language provides a means to understand the sensory-motor influences on the neural organization of language. The goals of the present proposal are to uncover the neural basis of sign language using modern lesion-deficit mapping. This will not only answer some fundamental questions about the neural basis of sign language and related processes and address questions about the sensory-motor forces that shape language organization generally, but will also provide much needed information on the clinical-anatomic correlates of sign language aphasia. We propose three specific aims. Aim 1: To determine whether the overall lesion pattern associated with sign language aphasia is similar to that found for spoken language using quantitative lesion-symptom mapping methods. Aim 2: To map the lesion pattern associated with more fine-grained measures of sign language production, sign language comprehension, and related function using quantitative lesion-symptom mapping methods. Aim 3: To assess the neural basis of naming ability and working memory for signs using the lesion method. PUBLIC HEALTH RELEVANCE: An important aspect of the mission of NIDCD is research that leads to increased understanding and treatment of language and communication disorders, particularly with respect to deafness and sign language. Relatively little research has targeted the breakdown of sign language as a result of brain lesions until our previous studies; the program proposed here using modern lesion-symptom approaches provides important new tools for the understanding and treatment of language disorders in deaf signers. This will have implications across a wide range of public health domains and directly benefits clinicians, educators, and individuals caring for deaf signers with brain lesions and/or language disorders.

描述（由申请人提供）：手语提供了一种理解感官运动对语言神经组织的影响的方法。本提案的目标是使用现代病变缺陷映射揭示手语的神经基础。这不仅会回答有关手语和相关过程的神经基础的一些基本问题，并解决有关通常塑造语言组织的感官运动力量的问题，而且还将提供有关临床 - 动态语言相关性的急需信息。我们提出了三个具体目标。目的1：确定与手语失调相关的总体病变模式是否类似于使用定量病变 - 症状映射方法对口语发现的整体病变模式。目的2：使用定量病变 - 检查者映射方法，绘制与手语的产生，手语理解和相关功能的更细粒度量度相关的病变模式。目标3：使用病变方法评估命名能力和工作记忆的神经基础。公共卫生相关性：NIDCD任务的一个重要方面是研究，导致对语言和沟通障碍的理解和治疗增加，尤其是在耳聋和手语方面。由于脑部病变，直到我们先前的研究，因此相对较少的研究目标是针对手语的细分。使用现代病变症状方法在此提出的计划为理解和治疗聋人签名者的语言障碍提供了重要的新工具。这将在广泛的公共卫生领域产生影响，并直接使临床医生，教育工作者和个人照顾患有脑部病变和/或语言障碍的聋人签名者。