The overlap of speech production and verbal working memory

言语产生和言语工作记忆的重叠

• 批准号: 10735031
• 负责人: Gregory B Cogan
• 金额: $ 48.26万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735031
• 关键词: Address; American; Anatomy; Apraxias; Architecture; Behavior; Behavioral; Brain; Clinic; Clinical; Clinical Research; Cognition; Data; Dissociation; Electric Stimulation; Electrocorticogram; Electrodes; Environment; Epilepsy; Etiology; Functional disorder; Grain; Human; Implanted Electrodes; Inferior; Knowledge; Language; Language Development Disorders; Language Disorders; Lesion; Link; Location; Maintenance; Maps; Measures; Methods; Modeling; Modification; Monitor; Motor; Motor Cortex; Neuroanatomy; Operative Surgical Procedures; Parietal; Patients; Population; Production; Property; Recovery; Rehabilitation therapy; Research; Resolution; Role; Sampling; Series; Short-Term Memory; Signal Transduction; Site; Specificity; Speech; Speech Disorders; Stroke; Symptoms; System; Techniques; Temporal Lobe; Testing; Time; Translational Research; Update; clinical care; cognitive process; density; design; flexibility; insight; memory process; neural; neural circuit; neuromechanism; neurosurgery; neurotransmission; novel; novel therapeutic intervention; phonology; response; sound; speech recognition; stroke rehabilitation; stroke-induced aphasia; temporal measurement; verbal

Abstract To enable the expression of ideas in everyday conversation, our brain must hold on to speech information for short periods of time in verbal working memory (vWM). This is particularly important for everyday conversation that takes place in chaotic environments: Plans for speaking change quickly, and the brain has to adapt to these changes. Previous models of vWM, have suggested that vWM is anatomically and functionally discrete, with only indirect interactions with speech production. Evidence from lesions following strokes however, have shown a wide range of speech production deficits that are also associated with problems with vWM, arguing against a strong dissociation between speech production and vWM. We propose instead that vWM is integrated in the speech production planning system, sharing an anatomical and functional substrate. To study this overlap, we propose to examine neural responses associated with this functional overlap through a population of neurosurgical patients who as part of their clinical care have electrodes implanted directly in their brain, giving us a unique opportunity to study the human brain at a greater resolution that has been done in the past. We will leverage this access to address the following questions: 1) Does speech production and vWM overlap in the brain? 2) What kind of information is held when planning for speech production? 3) What motor features are shared between speech production and vWM? We will use a series of tasks that are designed to separate out the role of vWM for different speech production components and measure human brain responses using direct brain recordings, including high density electrodes that have unprecedented spatial resolution (<1 mm, up to 1024 electrodes for a 10 x increase in sampling). Understanding this basic cognitive process and their role in everyday language use will lead to more targeted approaches to help the over 1 million Americans who suffer from stroke-induced aphasia.

抽象的 为了能够在日常对话中表达想法，我们的大脑必须保留语音信息 言语工作记忆（vWM）的短时间。这对于日常对话尤其重要 发生在混乱环境中的情况：说话的计划变化很快，大脑必须适应这些 变化。以前的 vWM 模型表明，vWM 在解剖学和功能上是离散的，仅 与言语产生的间接相互作用。然而，中风后病变的证据表明 广泛的言语产生缺陷也与 vWM 问题相关，反对 语音产生和 vWM 之间存在很强的分离性。相反，我们建议将 vWM 集成到 语音制作规划系统，共享解剖学和功能基底。为了研究这种重叠，我们 提议通过一群人来检查与这种功能重叠相关的神经反应 作为临床护理的一部分，神经外科患者的大脑中直接植入电极，从而给予 我们有一个独特的机会以比过去更高的分辨率研究人脑。我们将 利用此访问权限来解决以下问题：1) 语音生成和 vWM 在 脑？ 2) 策划演讲制作时掌握哪些信息？ 3) 电机的特点是什么 语音生成和 vWM 之间共享吗？我们将使用一系列旨在分离出的任务 vWM 对于不同语音产生组件的作用，并使用直接测量人脑反应 大脑记录，包括具有前所未有的空间分辨率（<1毫米，高达 1024 个电极，采样量增加 10 倍）。了解这一基本认知过程及其在其中的作用 日常语言的使用将带来更有针对性的方法来帮助超过 100 万遭受苦难的美国人 中风引起的失语症。