FASEB Summer Conference on Helicase and NTP-Driven Nucleic Acid Motors: Structure

FASEB 夏季会议：解旋酶和 NTP 驱动的核酸马达：结构

基本信息

批准号：
7275465
负责人：
Timothy M Lohman
金额：
$ 0.5万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-15 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7275465
关键词：
Advertising Aging Air Conditioning American Architecture Area Biogenesis Biological Biology Biomedical Research Bloom Syndrome California Cell Wall Cells Cockayne Syndrome Communities Complex Condition DNA DNA biosynthesis Data Defect Disease Enzymes Equipment Eye Fees Female Funding Future Gene Expression Genes Genetic Genetic Conjugation Genetic Transcription Genomic Instability Goals Growth Guidelines Hereditary Disease Housing Human Human Genetics Hydrolysis Incidence Inherited Journals Left Malignant Neoplasms Medical Membrane Molecular Motors Motor Movement Mutation Nature Newsletter Nucleic Acids Oral Participant Process Protein Binding Proteins Publications Publishing RNA RNA Degradation RNA Editing RNA Splicing RNA Transport Recruitment Activity Regulation Research Research Personnel Resort Ribosomes Role Science Scientific Societies Scientist Site Societies Structural Biologist Structure Students Switzerland Translations Underrepresented Minority Universities Viral Packaging Washington Werner Syndrome Woman Xerodermas base day enzyme activity helicase human disease insight interest medical schools nucleic acid metabolism posters programs recombinational repair response symposium translocase tumorigenesis virology

项目摘要

DESCRIPTION (provided by applicant): This application is for partial funding of the 2007 FASEB Summer Conference on "Helicases and NTP-Driven Nucleic Acid Motors: Structure, Function, Mechanism and Roles in Human Diseases." The conference will be held from June 23 to June 28, 2007 at the Hyatt Grand Champions Resort & Spa in Indian Wells, CA under the auspices of the Federation of American Societies of Experimental Biology (FASEB). There will be nine major scientific sessions; each session will include an average of four to five speakers, each presenting a 25-minute oral talk. There also will be two poster sessions, both of which will last two days. Helicases are molecular motor proteins that use the energy of NTP hydrolysis to translocate unidirectionally along nucleic acids, separating the complementary strands of the nucleic acid duplex. Helicase/translocase proteins also can destabilize the secondary structure of RNA, remove proteins bound to nucleic acid segments, and facilitate the movement of DNA and RNA chains through various pores, cell walls, and membranes. As a consequence of such activities, these enzymes serve as integral components of the cellular machineries responsible for all nucleic acid transactions, including DNA replication, repair, recombination, transcription, ribosome biogenesis, translation, RNA splicing, RNA editing, RNA transport, RNA degradation, bacterial conjugation, and viral packaging/unpackaging. The central nature of helicases and translocases to biomedical research has been underscored by the recent discovery that several inherited human diseases (e.g. Bloom syndrome, Werner syndrome, Cockayne syndrome and Xeroderma pigmentosum) are caused by defects in genes encoding specific helicases. Helicase defects are also associated with genomic instability and an increased cancer incidence. Despite the importance of this group of proteins, however, there is still much that we do not understand about helicase structure and mechanism; we know even less about the biological role of helicases in complex processes like oncogenesis and aging. The helicase/translocase field is progressing at an extremely rapid pace, with new insights into architecture, function, and the role of helicases in human disease emerging on a weekly basis. This is the third FASEB meeting on this subject (the meeting in 2005 was organized through EMBO) since discovery of the first helicase about 30 years ago. Demand has increased with each session, further highlighting the general interest of this research area to the scientific community at large. This proposal will highlight the background and goals of the 2007 FASEB meeting, with an eye to bring together structural biologists, enzymologists, biochemists, geneticists, and clinicians to share ideas and new information on these enzymes, crosstalk that is key to inform and facilitate research breakthroughs in the future.

描述（由申请人提供）：本申请为 2007 年 FASEB 夏季会议“解旋酶和 NTP 驱动的核酸马达：结构、功能、机制和在人类疾病中的作用”提供部分资助。会议由美国实验生物学会联合会 (FASEB) 主办，将于 2007 年 6 月 23 日至 28 日在加利福尼亚州印第安维尔斯的 Hyatt Grand Champions Resort & Spa 举行。将有九场主要科学会议；每场会议平均有四到五名演讲者，每人进行 25 分钟的口头演讲。还将有两次海报展示会，均持续两天。解旋酶是分子马达蛋白，利用 NTP 水解的能量沿着核酸单向易位，分离核酸双链体的互补链。解旋酶/转位酶蛋白还可以破坏 RNA 二级结构的稳定性，去除与核酸片段结合的蛋白质，并促进 DNA 和 RNA 链通过各种孔、细胞壁和膜的运动。由于这些活动，这些酶作为负责所有核酸交易的细胞机器的组成部分，包括 DNA 复制、修复、重组、转录、核糖体生物合成、翻译、RNA 剪接、RNA 编辑、RNA 运输、RNA 降解、细菌结合和病毒包装/拆包。最近的发现强调了解旋酶和转位酶在生物医学研究中的核心性质，即几种遗传性人类疾病（例如布卢姆综合征、沃纳综合征、科凯恩综合征和着色性干皮病）是由编码特定解旋酶的基因缺陷引起的。解旋酶缺陷还与基因组不稳定和癌症发病率增加有关。然而，尽管这组蛋白质很重要，但我们对解旋酶的结构和机制仍有很多不了解的地方；我们对解旋酶在肿瘤发生和衰老等复杂过程中的生物学作用知之甚少。解旋酶/转位酶领域正在以极快的速度发展，每周都会出现对解旋酶的结构、功能和在人类疾病中的作用的新见解。这是自大约 30 年前发现第一个解旋酶以来，第三次 FASEB 就该主题召开会议（2005 年的会议是通过 EMBO 组织的）。每届会议的需求都在增加，进一步凸显了整个科学界对该研究领域的普遍兴趣。该提案将强调 2007 年 FASEB 会议的背景和目标，着眼于将结构生物学家、酶学家、生物化学家、遗传学家和临床医生聚集在一起，分享关于这些酶的想法和新信息，串扰是为研究提供信息和促进研究的关键未来的突破。