Successful Aging in a Time of Wildfires

野火时期的成功老龄化

• 批准号: 10688315
• 负责人: DAVID M ABRAMSON
• 金额: $ 68.08万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688315
• 关键词: Acute; Address; Affect; Aging; Air; Area; Behavior; Behavioral; Biological; Biological Markers; Burn injury; California; Carbon Monoxide; Cardiovascular system; Censuses; Chemicals; Chronic; Climatology; Cognitive; Communities; Country; Data; Disasters; Dose; Elderly; Enrollment; Epidemiology; Epigenetic Process; Ethnic Origin; Ethnic group; Exposure to; Fire - disasters; Frequencies; Geography; Gerontology; Health; Heart Diseases; Home; Human; Immune; Indoor Air Pollution; Indoor Air Quality; Inflammatory; Longitudinal cohort; Measures; Mediating; Messenger RNA; Meteorology; MicroRNAs; Modeling; Molecular; Molecular Profiling; Neurocognitive; Neurologic; Outcome; Ozone; Participant; Particulate Matter; Pathway interactions; Population; Population Density; Prevention; Process; Psychosocial Factor; Psychosocial Influences; Public Health; Race; Research; Research Design; Research Personnel; Respiratory Disease; Respiratory System; Risk; Saliva; Salivary; Sampling; Seasons; Series; Shapes; Small RNA; Smoke; Social Behavior; Social support; Socioeconomic Status; Sociology; Source; Subgroup; Surveys; Testing; Time; Toxin; Tracer; Travel; Wildfire; atmospheric sciences; base; biobank; biopsychosocial factor; coarse particles; cohort; design; epigenetic marker; ethnic diversity; exosome; fine particles; immune function; indoor air; indoor exposure; interdisciplinary approach; physical conditioning; pollutant; protective behavior; psychologic; racial diversity; recruit; research study; respiratory; response; saliva sample; social; sociodemographic factors; time use

“Successful Aging in a Time of Wildfires” is a research study designed to examine the effects of chronic and acute wildfire smoke exposure on the successful aging of community-dwelling older adults living in California. Over 1.4 million wildfires have occurred in the U.S. since 2000, burning an average of 7 million acres annually. Emissions from wildfires pose significant threats to human health, including cardiovascular, respiratory, and neuro-cognitive effects, and are estimated to cause more than 15,000 fatalities per year. Older adults are particularly vulnerable to the impact of wildfire emissions, which exacerbate respiratory and cardiac diseases. However, beyond direct physical health effects it remains unclear how sociodemographic factors shape older adult exposure to wildfire smoke and how this exposure subsequently impacts the functional, cognitive, and socio-behavioral aspects of successful aging. As California is at particularly heightened risk of wildfires, this study will recruit a racially and ethnically diverse longitudinal cohort of 1,000 community-dwelling older adults from California and apply a hierarchical socio-ecological model to the question of whether exposure to wildfire emissions affects the successful aging of older adults. The strategy reflects a multidisciplinary approach in which the researchers measure and model ambient toxins in both outdoor and indoor air; collect and assess epigenetic changes in older adults’ exosomes; and evaluate the social, psychological, and behavioral factors that moderate the environmental and biological exposure factors and their impact on successful aging. The broad long-term objectives of the study are to identify those factors amenable to prevention, mitigation, or adaptation, so that older adults living in wildfire-susceptible regions of the country can safeguard their health by attending to the air around them, the buildings in which they live, and to the social supports and protective behaviors in which they can engage. The research study has four specific research aims: (1) to develop a California-based observational cohort of older adults with various levels of wildfire exposure from 2002-present; (2) to estimate outdoor and indoor exposure to chemically- explicit wildfire emissions among cohort participants; (3) to analyze saliva samples to identify epigenetic markers of wildfire-exposure, and analyze their association with inflammatory processes and functional impacts on neurological, cardiovascular, and respiratory systems; and (4) to develop and test an ecological model for successful aging in older adults exposed to wildfire emissions that integrates exposure and behavioral data to determine the relationship between wildfire smoke exposure and successful aging outcomes.

“野火时期的成功老龄化”是一项旨在检验野火影响的研究 慢性和急性野火烟雾暴露对社区老年人成功老龄化的影响 自 2000 年以来，美国已发生超过 140 万起野火， 每年平均燃烧 700 万英亩土地，造成严重威胁。 对人类健康，包括心血管、呼吸和神经认知影响， 据估计，每年造成超过 15,000 人死亡，老年人尤其容易受到伤害。 野火排放的影响，加剧呼吸系统和心脏病。 然而，除了直接的身体健康影响之外，目前还不清楚社会人口统计学如何影响 影响老年人接触野火烟雾的因素以及随后这种接触的方式 影响成功老龄化的功能、认知和社会行为方面。 加利福尼亚州面临着特别重大的野火风险，这项研究将招募不同种族和 来自加利福尼亚州的 1,000 名社区老年人的种族多元化纵向队列 并将分层社会生态模型应用于是否暴露于野火的问题 排放影响老年人的成功老龄化 该战略反映了多学科的成果。 研究人员测量和模拟室外和室外环境毒素的方法 室内空气；收集和评估老年人外泌体的表观遗传变化； 调节环境和生物的社会、心理和行为因素 暴露因素及其对成功老龄化的影响。 研究的目的是确定那些适合预防、缓解或适应的因素，以便 生活在该国山火易发地区的老年人可以通过以下方式保护自己的健康 关注他们周围的空气、他们居住的建筑物以及社会支持和 他们可以参与的保护行为有四项具体研究。 目标：(1) 建立一个以加州为基础的观察队列，对象是具有不同程度的老年人 2002 年至今的野火暴露情况；(2) 估计室外和室内化学物质暴露情况： 参与者中明确的野火排放队列；（3）分析唾液样本以识别 野火暴露的表观遗传标记，并分析它们与炎症的关联 对神经、心血管和呼吸系统的过程和功能影响； (4) 开发并测试暴露于环境的老年人成功衰老的生态模型 野火排放，整合暴露和行为数据以确定关系 野火烟雾暴露与成功的老龄化结果之间的关系。