University of Pittsburgh Clinical and Translational Science Institute

匹兹堡大学临床与转化科学研究所

• 批准号: 7485627
• 负责人: STEVEN E REIS
• 金额: $ 440.04万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7485627
• 关键词: Clinical; Clinical Research; Commit; Communities; Community Health; Development; Discipline; Environment; Goals; Health; Health Sciences; Healthcare Systems; Home environment; Individual; Informatics; Institutes; Institution; Interdisciplinary Study; Knowledge; Medical center; Participant; Pediatric Hospitals; Pennsylvania; Range; Research; Research Training; Resources; Risk; SECTM1 gene; Schools; Scientist; Site; Structure; Students; Training Programs; Translating; Translational Research; Universities; cancer Biomedical Informatics Grid; health practice; high school; improved; innovation; knowledge translation; minority health; novel; pre-clinical research; programs; research study; tool

As one of the nation's leading academic research centers, the University of Pittsburgh has both an opportunity and an obligation to take the inherent risks associated with reengineering a successful research enterprise to undertake a transformative initiative that will result in the development and advancement of clinical and translational science as a distinct discipline in western Pennsylvania. The University is committed to transforming its culture, environment, and structure to achieve this goal by forming the Clinical and Translational Science Institute (CTSI). The CTSI will serve as the integrative academic home for clinical and translational scientists across the University's six health sciences schools; Carnegie Mellon University; the University of Pittsburgh Medical Center (UPMC), one of the nation's largest and most financially successful academic health care systems; and the region. The CTSI's primary focus is to develop, nurture, and support a cadre of clinical and translational scientists by building on the University's existing clinical research training programs (Roadmap K12, K30) to establish a comprehensive program with activities ranging from early research exposure for high school students to advanced doctoral programs. Through "integration and innovation," the CTSI will excel in the development of new biomedical knowledge and the translation of that knowledge from the basic and preclinical research settings to individuals, communities, and health practice. The Children's Hospital of Pittsburgh's General Clinical Research Center (GCRC) and the four sites of the University of Pittsburgh GCRC will be reengineered, integrated, and augmented by new CTSI communitybased and minority health focused centers to develop efficient, accessible, and widely used participant and clinical interaction resources. The CTSI Center for Clinical and Translational Informatics, which is developing translational research informatics tools for the NCI Cancer Biomedical Informatics Grid Initiative, will infuse informatics tools into the entire lifecycle of clinical research studies and develop an online collaborative research community. Innovative interdisciplinary research initiatives will be developed through the ten CTSI resource cores and translated to health practice via a novel CTSI community partnership program and through centralization of UPMC's extensive clinical networks. The resulting transformations in the institution, scientist, research, and health practice will improve health locally, regionally, and nationally.

作为美国领先的学术研究中心之一，匹兹堡大学都有 机会和承担与重新设计成功研究相关的固有风险的义务 企业实施一项变革性倡议，将导致发展和进步 宾夕法尼亚州西部的临床和转化科学是独特的学科。大学的承诺 改变其文化，环境和结构，以形成临床和 翻译科学研究所（CTSI）。 CTSI将作为临床和 该大学六所健康科学学校的转化科学家；卡内基·梅隆大学；这 匹兹堡大学医学中心（UPMC），美国最大，最大的成功之一 学术卫生保健系统；和该地区。 CTSI的主要重点是开发，培养和支持 建立大学现有临床研究培训的临床和转化科学家干部 计划（路线图K12，K30），以建立一个全面的计划，其活动从早期 高中生研究高级博士课程的研究。通过“集成和 创新，“ CTSI将在开发新的生物医学知识和翻译方面表现出色 从基本和临床前研究环境到个人，社区和健康实践的知识。 匹兹堡一般临床研究中心（GCRC）的儿童医院和四个地点 匹兹堡大学GCRC将由新的CTSI社区重新设计，整合和增强 以少数民族健康为中心，以发展高效，可访问和广泛使用的参与者和 临床相互作用资源。 CTSI临床和翻译信息学中心正在开发 NCI癌症生物医学信息学网格计划的转化研究信息学工具将注入 信息学工具进入临床研究的整个生命周期，并开发在线协作 研究社区。创新的跨学科研究计划将通过十个CTSI制定 资源核心，并通过新颖的CTSI社区合作计划转化为健康实践，并将其转化为 通过集中化UPMC广泛的临床网络。机构的最终转变， 科学家，研究和健康实践将在本地，地区和全国改善健康。