CREATION OF MODEL BASE AMINO ACID LIBRARIES

模型基础氨基酸库的创建

• 批准号: 7723467
• 负责人: ALAN D FRANKEL
• 金额: $ 0.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723467
• 关键词: Amino Acids; Base Pairing; Binding Proteins; Biological Process; Computer Graphics; Computer Retrieval of Information on Scientific Projects Database; DNA; Databases; Funding; Grant; Hydrogen Bonding; Imagery; Institution; Laboratories; Libraries; Modeling; Nucleic Acids; Process; RNA; Regulation; Research; Research Personnel; Resources; Source; Specificity; Study models; United States National Institutes of Health; Viral; Writing; base; insight; interest; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific binding of proteins to DNA and RNA is important in regulation of biological processes and viral lifecycles. Hydrogen bonds often dominate specific interactions, and a modeling study of amino acid hydrogen bond compatibility with particular bases, base pairs, and base steps may help us understand and predict the basis of amino acid-nucleic acid specificity. We have written a program that systematically analyzes the hydrogen bonding possibilities between amino acids and single bases, and amino acids and base pairs. We are in the process of analyzing the resulting database for interesting insights into specificity. This program, in addition to requiring computational power, requires the visualization capabilities of the Computer Graphics Laboratory.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 蛋白质与 DNA 和 RNA 的特异性结合对于生物过程和病毒生命周期的调节非常重要。 氢键通常主导特定的相互作用，氨基酸氢键与特定碱基、碱基对和碱基步骤相容性的建模研究可以帮助我们理解和预测氨基酸-核酸特异性的基础。 我们编写了一个程序，系统地分析氨基酸和单个碱基以及氨基酸和碱基对之间氢键的可能性。 我们正在分析生成的数据库，以获取对特异性的有趣见解。 该程序除了需要计算能力之外，还需要计算机图形实验室的可视化能力。