CREATION OF MODEL BASE AMINO ACID LIBRARIES

模型基础氨基酸库的创建

• 批准号: 7955462
• 负责人: ALAN D FRANKEL
• 金额: $ 0.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955462
• 关键词: Amino Acids; Base Pairing; Binding Proteins; Biological Process; Computer Graphics; Computer Retrieval of Information on Scientific Projects Database; DNA; Databases; Funding; Grant; Hydrogen Bonding; Imagery; Informatics; Institution; Laboratories; Libraries; Modeling; Nucleic Acids; Process; RNA; Regulation; Research; Research Personnel; Resources; Source; Specificity; Study models; United States National Institutes of Health; Viral; Writing; base; biocomputing; insight; interest; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific binding of proteins to DNA and RNA is important in regulation of biological processes and viral lifecycles. Hydrogen bonds often dominate specific interactions, and a modeling study of amino acid hydrogen bond compatibility with particular bases, base pairs, and base steps may help us understand and predict the basis of amino acid-nucleic acid specificity. We have written a program that systematically analyzes the hydrogen bonding possibilities between amino acids and single bases, and amino acids and base pairs. We are in the process of analyzing the resulting database for interesting insights into specificity. This program, in addition to requiring computational power, requires the visualization capabilities of the Computer Graphics Laboratory.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 蛋白质与DNA和RNA的特异性结合在调节生物过程和病毒生命周期中很重要。 氢键通常主导特定的相互作用，以及氨基酸氢键与特定碱基，碱基对和基本步骤兼容的建模研究可能有助于我们理解和预测氨基酸核酸特异性的基础。 我们编写了一个程序，该程序可以系统地分析氨基酸和单个碱之间的氢键可能性，以及氨基酸和碱基对。 我们正在分析所得数据库，以了解对特异性的有趣见解。 除需要计算能力外，该程序还需要计算机图形实验室的可视化功能。