HIV-HOST PROTEIN COMPLEXES

HIV 宿主蛋白复合物

• 批准号: 8170565
• 负责人: ALAN D FRANKEL
• 金额: $ 0.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170565
• 关键词: Complex; Computer Graphics; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; HIV; Institution; Laboratories; Proteins; Proteomics; RNA; RNA-Binding Proteins; Research; Research Personnel; Resources; Source; Structure; Transcription Coactivator; United States National Institutes of Health; Work; protein complex; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have been conducting proteomic studies to identify host proteins that interact with HIV proteins in order to determine the structures of relevant complexes. Our structural studies focus primarily on complexes with the Tat transcription activator and Rev RNA export factor, both RNA-binding proteins. Graphical analyses of the structures utilizing Computer Graphics Laboratory tools are instrumental for this work.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们一直在进行蛋白质组学研究，以鉴定与HIV蛋白相互作用的宿主蛋白，以确定相关复合物的结构。 我们的结构研究主要集中于与TAT转录激活剂和Rev RNA输出因子（均为RNA结合蛋白）的复合物。 利用计算机图形实验室工具的结构的图形分析对这项工作有用。