PHOSPHODIESTERASE 3 INHIBITORS: BLOCKERS OF OOCYTE MATURATION AND FERTILIZATION

磷酸二酯酶 3 抑制剂：卵母细胞成熟和受精的阻断剂

• 批准号: 7561913
• 负责人: JEFFREY T. JENSEN
• 金额: $ 7.59万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561913
• 关键词: Adverse effects; Affect; Biology; Chronic; Computer Retrieval of Information on Scientific Projects Database; Contraceptive Agents; Contraceptive methods; Fertilization; Funding; Gonadotropins; Grant; Health Benefit; Institution; Macaca mulatta; Morals; Ovarian Stimulations; Ovary; Ovulation; Partner in relationship; Periodicity; Pregnancy; Primates; Protein Isoforms; Protocols documentation; Purpose; Research; Research Methodology; Research Personnel; Resources; Source; United States National Institutes of Health; Unwanted Birth; abortion; corpus luteum; in vivo; inhibitor/antagonist; novel; oocyte maturation; phosphoric diester hydrolase; prevent; selective expression; unintended pregnancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Contraception provides significant preventative health benefits by reducing unintended pregnancy, abortions, and unwanted births. As side effects, access, and cultural or moral objections limit the universal acceptance of current methods, research into novel contraceptives is warranted. The purpose of this grant is to explore the hypotheses that selective expression of phosphodiesterase (PDE) isoforms exists in the primate ovary, that selective blockade of PDE3 can be exploited to prevent spontaneous and gonadotropin-induced oocyte maturation, and that chronic treatment with a PDE3 inhibitor can prevent pregnancy in primates without affecting menstrual cyclicity or luteal function. The Specific Aims are to (1) describe the basic biology of PDE expression in the primate ovary; (2) to determine if PDE3 inhibitors prevent oocyte maturation, but not ovulation and function of the corpus luteum in rhesus monkeys undergoing controlled ovarian stimulation (COS) protocols or during natural cycles in vivo; and (3) to determine whether PDE3 inhibitors function as contraceptive agents in regularly cycling rhesus monkeys in paired mating situations.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 避孕方法通过减少意外怀孕，堕胎和不必要的出生来提供重大的预防健康益处。随着副作用，访问以及文化或道德异议限制了当前方法的普遍接受，因此有必要研究对新型避孕方法的研究。这笔赠款的目的是探索在灵长类卵巢中存在选择性表达磷酸二酯酶（PDE）同工型的假设，可以利用PDE3的选择性阻断，以防止自发性和促性腺激素诱导的卵母细胞的成熟，以及对PDE 3的预防性治疗，并促进PDE3的预期，并促进PDE3的预期。黄体功能。 具体目的是（1）描述灵长类动物卵巢中PDE表达的基本生物学； （2）确定PDE3抑制剂是否可以防止卵母细胞成熟，但不能防止卵巢猴中的luteum luteum的排卵和功能，并在卵巢刺激（COS）方案中还是在体内自然周期期间； （3）确定PDE3抑制剂是否在配对的交配情况下定期循环恒河猴中起避孕剂的作用。