TRANSCERVICAL POLIDOCANOL FOAM AS NONSURGICAL FEMALE STERILIZATION TECHNIQUE

经宫颈聚多醇泡沫作为非手术女性绝育技术

• 批准号: 8357847
• 负责人: JEFFREY T. JENSEN
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357847
• 关键词: Area; Cervix Uteri; Epithelium; Family planning for men/sterilization; Female Sterilization; Fertility; Funding; Grant; Human; Injury; Intra-abdominal; Macaca; Mammalian Oviducts; Methods; Microscopic; Modeling; National Center for Research Resources; Organ; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Techniques; Tissues; United States National Institutes of Health; Uterine cavity; cost; in vivo; novel strategies; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. High rates of human fertility are endemic in many of the poorest areas on earth. Reversible methods are impractical for a variety of reasons. Therefore, safe and low cost non-surgical methods of female and male sterilization are urgently needed. This project will use the macaque model to explore a novel approach for non-surgical female sterilization. The purpose of this project is to explore the hypotheses that Polidocanol foam delivered transcervically will selectively damage the fallopian tube epithelium and result in tubal blockage without injury to non-target tissues such as the uterine cavity or intra abdominal organs. The Specific Aims are to: (1) develop a reproducible technique to cannulate the macaque cervix and assess tubal patency in vivo; (2) determine if Polidocanol foam administered transcervically will result in tubal blockade observed in vivo; and 3) describe the gross and microscopic tissue effects of Polidocanol foam on the reproductive tract and non-target tissues.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 在地球上许多最贫穷的地区，人类生育率的高率是地方性的。 可逆方法由于多种原因是不切实际的。因此，迫切需要对女性和男性绝育的安全和低成本的非手术方法。 该项目将使用猕猴模型探索一种新的非手术女性灭菌方法。 该项目的目的是探讨polidocanol泡沫经胸腔供应的假设将有选择地损害输卵管上皮，并导致输卵管阻塞，而不会损害子宫腔或腹部内脏等非目标组织。 具体的目的是：（1）开发一种可再现技术来插入猕猴子宫颈并评估体内的输卵管通畅； （2）确定polidocanol泡沫是否经胸腔给药是否会导致体内观察到的输卵管阻塞； 3）描述polidocanol泡沫对生殖道和非目标组织的总体和微观组织效应。