The Center for Innovation and Translation of Point of Care Technologies for Equitable Cancer Care (CITEC)

公平癌症护理护理点技术创新与转化中心 (CITEC)

基本信息

批准号：
10715740
负责人：
Sharmila Anandasabapathy
金额：
$ 130万
依托单位：
RICE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-13 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10715740
关键词：
Acceleration Accounting Address Adoption Anus Award Brazil Cancer Detection Cancer Hospital Cancer Patient Caring Cervix Uteri Cessation of life Clinical Collaborations Colon Communities Complex Country Dedications Development Diagnosis Disease Disparity Diverse Workforce Early Diagnosis Early treatment Engineering Ensure Epithelium Equity Esophagus Evaluation Gastrointestinal tract structure Goals Health Health Sciences Human Development Incidence Industrialization Infrastructure Lesion Malignant Neoplasms Medically Underserved Area Medicine Mozambique Oral cavity Organ Outcome Pain Palliative Care Performance Point of Care Technology Prevention Prevention approach Prevention program Primary Care Process Productivity Public Health Recommendation Rectum Research Research Personnel Resource-limited setting Resources Rice Scientist Screening for cancer Site Stomach Suggestion Surface Sustainable Development Technology Testing Texas Training Translating Translations United States National Institutes of Health Universities University of Texas M D Anderson Cancer Center Work World Health Organization anticancer research cancer care cancer health disparity cancer prevention cancer therapy cancer type college commercialization cost disparity reduction ethnic minority implementation barriers improved improved outcome indexing innovation low and middle-income countries medically underserved medically underserved population meetings member mortality new technology novel personalized approach point of care point of care testing premalignant premature preventable death prevention service primary care setting prototype racial minority rectal screening technology development technology research and development tool training opportunity underserved community usability

Acceleration Accounting Address Adoption Anus Award Brazil Cancer Detection Cancer Hospital Cancer Patient Caring Cervix Uteri Cessation of life Clinical Collaborations Colon Communities Complex Country Dedications Development Diagnosis Disease Disparity Diverse Workforce Early Diagnosis Early treatment Engineering Ensure Epithelium Equity Esophagus Evaluation Gastrointestinal tract structure Goals Health Health Sciences Human Development Incidence Industrialization Infrastructure Lesion Malignant Neoplasms Medically Underserved Area Medicine Mozambique Oral cavity Organ Outcome Pain Palliative Care Performance Point of Care Technology Prevention Prevention approach Prevention program Primary Care Process Productivity Public Health Recommendation Rectum Research Research Personnel Resource-limited setting Resources Rice Scientist Screening for cancer Site Stomach Suggestion Surface Sustainable Development Technology Testing Texas Training Translating Translations United States National Institutes of Health Universities University of Texas M D Anderson Cancer Center Work World Health Organization anticancer research cancer care cancer health disparity cancer prevention cancer therapy cancer type college commercialization cost disparity reduction ethnic minority implementation barriers improved improved outcome indexing innovation low and middle-income countries medically underserved medically underserved population meetings member mortality new technology novel personalized approach point of care point of care testing premalignant premature preventable death prevention service primary care setting prototype racial minority rectal screening technology development technology research and development tool training opportunity underserved community usability

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项目摘要

Abstract: Cancer is the first or second leading cause of premature death in 134 of 183 countries, and it is estimated that global incidence of cancer will increase by 50% from 2018 to 2040. The number of cases is projected to double in countries with low Human Development Index; these countries have the least resources and infrastructure to adequately care for cancer patients. Disparities exist within countries; in the US, racial and ethnic minorities and other medically underserved populations share a disproportionate burden for many types of cancer. Most cancers can be cured if detected early and treated effectively. To reduce premature death, the World Health Organization recommends implementing early cancer detection and prevention programs at the primary care level. Yet, existing tests for early cancer detection are too complex and/or expensive to implement in primary care settings, particularly in medically underserved areas. We will establish the Center for Innovation and Translation of Point-of-Care Technologies for Equitable Cancer Care (CITEC) to identify high- priority clinical needs for POC cancer technologies; to accelerate development of effective, affordable technologies to meet these needs; to evaluate and improve the clinical and public health impact of POC technologies in diverse settings; and to train developers and users to create and disseminate more equitable POC technologies. CITEC will prioritize development of POC tests to detect cancers that arise in epithelial surfaces. Initially, we will focus on sites accessible for early detection because this is where POC technologies can have the most immediate impact. Targeted organ sites include the uterine cervix, gastro-intestinal tract (esophagus, stomach, colon, rectum, anus), and oral cavity; cancers in these sites account for 26% of global cases and 29% of global cancer deaths. CITEC builds on the highly productive 15-year collaboration between Rice University, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, and The University of Texas Health Science Center at Houston to develop and translate novel POC technologies to improve cancer care in both low- and high-resource settings. Joining with collaborators in Brazil at The University of Sao Paulo and Barretos Cancer Hospital and partners in Mozambique at The Universidade Eduardo Mondlane and Ministry of Health, we will create a collaborative center to support technology development and engage and support a global community of investigators dedicated to creating and scaling POC technologies for equitable cancer screening and diagnosis to facilitate early treatment. CITEC will support development of POC technologies to promote high priority topics of NIH cancer research, including precision approaches to prevention, screening and early detection, reducing disparities in cancer outcomes, and building a diverse workforce able to translate POC technologies from research and development to equitable implementation. CITEC will have a major impact on equitable prevention, diagnosis and early treatment of cancer in the US and worldwide, and will work with the POCTRN network to build a strong team of global partners to strengthen and sustain POC technology development.

抽象的：癌症是183个国家中134个早期死亡的第一或第二大原因，据估计全球从2018年到2040年，癌症发病率将增加50％。预计在人类发展指数低；这些国家的资源和基础设施最少，可以充分照顾癌症患者。国家存在差异；在美国，种族和少数民族以及其他医疗服务不足人口对许多类型的癌症负担不成比例的负担。大多数癌症可以及早发现，并且有效治疗。为了减少过早死亡，世界卫生组织建议实施早期癌症初级保健级别的检测和预防计划。然而，现有的早期癌症检测测试太复杂了和/或在初级保健环境中实施的昂贵，尤其是在医疗服务不足的地区。我们将建立公平癌症护理（CETEC）的创新和翻译中心，以识别高级 POC癌症技术的优先临床需求；加速开发有效，负担得起的技术满足这些需求；评估和改善POC技术在不同环境中的临床和公共卫生影响；并培训开发人员和用户创建和传播更公平的POC技术。 Citec将优先考虑开发POC测试以检测上皮表面中出现的癌症。最初，我们将专注于可访问的网站早期检测是因为这是POC技术可以产生最直接影响的地方。目标器官位置包括子宫宫颈，胃肠道（食管，胃，结肠，直肠，肛门）和口腔；这些网站的癌症占全球病例的26％和全球癌症死亡的29％。 Citec建立在高产15年的基础上赖斯大学，德克萨斯大学医学博士安德森癌症中心，贝勒医学院的合作，以及休斯敦的德克萨斯大学健康科学中心开发和翻译新颖的POC技术以改进低资源和高资源环境中的癌症护理。与圣保罗大学巴西的合作者加入巴雷托斯癌症医院和莫桑比克的合作伙伴爱德华多·蒙德兰大学和卫生部，我们将建立一个协作中心，以支持技术发展，参与和支持一个全球社区研究人员致力于创建和扩展POC技术，以促进公平的癌症筛查和诊断早期治疗。 CETEC将支持开发POC技术，以促进NIH癌的高优先级主题研究，包括预防，筛查和早期检测的精确方法，减少癌症的差异结果，并建立了能够将POC技术从研发转化为公平实施。 Citec将对公平预防，诊断和早期治疗产生重大影响美国和全球癌症，并将与Poctrn网络合作，建立一个强大的全球合作伙伴团队加强和维持POC技术开发。