Time Resolved MRA of the Intracranial Vasculature

颅内血管时间分辨 MRA

• 批准号: 7465057
• 负责人: TIMOTHY J CARROLL
• 金额: $ 38.52万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7465057
• 关键词: Affect; American; Aneurysm; Angiography; Architecture; Arteriovenous malformation; Atherosclerosis; Blood Vessels; Bolus Infusion; Brain; Brain Aneurysms; Brain hemorrhage; Catheters; Congenital arteriovenous malformation; Contrast Media; Diagnosis; Diagnostic Imaging; Disease; Dissection; Dose; Excision; Fistula; Goals; Image; Imaging Techniques; Injection of therapeutic agent; Invasive; Ionizing radiation; Length of Stay; Life; Magnetic Resonance Imaging; Medical; Nature; Nephrotoxic; Operative Surgical Procedures; Pathology; Patient Care; Patients; Physicians; Physiologic pulse; Protocols documentation; Pulse taking; Puncture procedure; Radial; Radiation; Radiosurgery; Range; Recovery; Reference Standards; Resolution; Risk; Roentgen Rays; Sampling; Slide; Stroke; Testing; Therapeutic Embolization; Three-Dimensional Image; Three-Dimensional Imaging; Time; Vascular Diseases; Work; base; cost; improved; millimeter; reconstruction; treatment planning; vascular bed

The broad, long-term goal of this work is to improve the diagnosis and treatment of patients with neurovascular disease. The diagnosis and treatment planning of often require the used of catheter- based x-ray angiography (XRA). Catheter angiography is the current referenced standard for intracranial angiography but exposes both the patients and physicians to high doses of radiation, requires an arterial puncture, the injection of nephrotoxic contrast agents and carries a slight risk of stroke. The use of intra-arterial catheters for XRA requires a hospital stay for recovery, adding to the cost of patient care. Magnetic Resonance Imaging (MRI) based angiographic images are widely available, and have reduced the use of XRA for the diagnosis of vascular disease in many vascular beds. However, due to the need of high frame images (up to 6 frames/sec) to capture bolus dynamics, XRA is still routinely performed to image the intracranial vasculature. We are developing an MRI-bases alternative to intracranial XRA based on using radial sampling and sliding window reconstruction. The minimally invasive nature of MR angiography will reduce the risk to patients undergoing diagnostic imaging of the brain. Using our approach to MR angiography can reach the frames and spatial resolution needed to capture the bolus dynamics that are normally observed with more invasive XRA. In the proposed work, we will implement our pulse sequence, validate the pulse sequence in phantoms, healthy normal subject, and in direct comparison with XRA in patients. We will test the following hypotheses: Specific Aim 1: We hypothesize that sliding window radial MRA can better depict flow dynamics than traditional block-wise MRI acquisitions. Specific Aim 2: We hypothesize that constrain reconstruction of radial sliding window images acquisition will improve the depiction of intracranial blood vessels without altering the imaging of flow dynamics. Specific Aim 3: We hypothesize that sliding window radial MRA can accurately depict the vasculature abnormalities in patients. Upon successful completion of this project we will have developed and validated a non-invasive adjunct to intracranial X-ray angiography We propose to develop an MRI-based imaging protocol for no-invasive imaging of the intracranial vasculature. Our goal is to develop a pulse sequence that can aid in the diagnosis and treatment planning of a wide range of neurovascular diseases. The current approach to this problem is catheter- based x-ray angiography which is invasive, carries a definite risk of stroke and subjects both patients and physicians to ionizing radiation. The successful completion of this project will results in fewer invasive imaging procedures being performed, resulting reduced risk to patients.

这项工作的广泛长期目标是改善患者的诊断和治疗 神经血管疾病。经常需要使用导管的诊断和治疗计划 基于X射线血管造影（XRA）。导管血管造影是当前的参考标准 颅内血管造影，但使患者和医生都暴露于高剂量的辐射， 需要动脉穿刺，注射肾毒性对比剂，并带有轻微的风险 中风。使用动脉内导管XRA需要住院才能恢复，增加了 患者护理费用。基于磁共振成像（MRI）的血管造影图像广泛 可用，并减少了XRA在许多血管中诊断血管疾病的使用 床。但是，由于需要高框架图像（最多6帧/秒）才能捕获推注 动力学，XRA仍经常进行以成像颅内脉管系统。我们正在发展 基于径向采样和滑动窗口的颅内XRA的MRI Bases替代 重建。 MR血管造影的最低侵入性性质将降低患者的风险 接受大脑的诊断成像。利用我们的血管造影MR可以到达 捕获通常是通常的推注动力学所需的帧和空间分辨率 观察到更具侵入性的XRA。在拟议的工作中，我们将实施我们的脉冲序列， 验证幻影中的脉冲序列，健康的正常受试者，并直接与XRA进行比较 在患者中。我们将检验以下假设： 特定目标1：我们假设滑动窗口径向MRA可以更好地描绘流程 动态比传统的块MRI获取。 特定目标2：我们假设限制了径向滑动窗口图像的重建 获取将改善颅内血管的描绘，而不会改变成像 流动动力学。 特定目标3：我们假设滑动窗口径向MRA可以准确描绘 患者的脉管系统异常。 成功完成该项目后，我们将开发并验证了非侵入性辅助手段 对于颅内X射线血管造影，我们建议开发一种基于MRI的成像方案，用于无创颅内成像 脉管系统。我们的目标是开发一个可以帮助诊断和治疗的脉冲序列 计划多种神经血管疾病。当前解决此问题的方法是导管 - 具有侵入性的基于X射线血管造影，具有中风的明确风险，受试者两人 和医生电离辐射。该项目的成功完成将导致更少 进行了侵入性成像程序，导致患者的风险降低。