Development of MRI-based Cerebral Oxygen Extraction Fraction

基于 MRI 的脑氧提取分数的开发

• 批准号: 8822294
• 负责人: TIMOTHY J CARROLL
• 金额: $ 18.56万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-15 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8822294
• 关键词: Age; Aging; Agreement; Angioplasty; Aspirin; Atherosclerosis; Beds; Biological Models; Blood; Blood Circulation; Blood Volume; Blood capillaries; Brain; Carotid Artery Diseases; Cephalic; Cerebrovascular Circulation; Cerebrum; Clinical; Data; Development; Development Plans; Diagnosis; Diagnostic; Disease; Evaluation; Financial compensation; Frequencies; Functional Imaging; Goals; Grant; HIV; Health; Health Care Costs; Human; Image; Imaging Techniques; Individual; Intracranial Atheroscleroses; Ischemic Stroke; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measures; Medical; Methods; Natural History; Oxygen; Oxygen Consumption; Pathology; Patient Schedules; Patients; Perfusion; Persons; Physiologic pulse; Physiological; Pilot Projects; Play; Population; Positron-Emission Tomography; Predisposition; Prevalence; Protocols documentation; Quality of life; Recruitment Activity; Recurrence; Reference Standards; Reporting; Research; Research Personnel; Retrieval; Risk; Role; Severities; Severity of illness; Signal Transduction; Stenosis; Stents; Stroke; Techniques; Tissues; Translating; Vascular blood supply; Work; arteriole; base; capillary; clinically significant; clopidogrel; cost; feeding; hemodynamics; high risk; imaging modality; improved; insight; metabolic rate; non-invasive imaging; novel; patient population; pressure; prevent; success

DESCRIPTION (provided by applicant): The broad, long term goal of this research is to improve the diagnosis and treatment of intracranial atherosclerotic disease (ICAD). The presence of intracranial atherosclerosis results in alterations in cerebral hemodynamics and also puts patients at risk for stroke. The prevalence of ICAD is known to increase with age indicating that is will be an increasing burden on healthcare cost with the aging of the population. Direct evaluation of tissue Oxygen Extraction Fraction (OEF) using positron emission tomography (PET) scans have provided direct insight into the severity, progression and risk of stroke in extra-cranial atherosclerosis (i.e. Carotid artery disease). Intracranial atherosclerosis induces a more focal loss of intracranial perfusion pressure and results in alterations in CBF, CBV, OEF. In this proposed work we will develop a new MRI pulse sequence for the quantification of OEF, verify its accuracy, reliability against PET.

描述（由申请人提供）：这项研究的广泛，长期目标是改善颅内动脉粥样硬化疾病（ICAD）的诊断和治疗。颅内动脉粥样硬化的存在导致脑血液动力学改变，并使患者处于中风的风险。已知ICAD的患病率随着年龄的增长而增加，这表明随着人口的衰老，医疗保健成本的负担将增加。使用正电子发射断层扫描（PET）扫描直接评估组织氧提取分数（OEF）已直接洞悉颅外动脉粥样硬化中的严重性，进展和中风风险（即颈动脉疾病）。颅内动脉粥样硬化诱导颅内灌注压力的局灶性损失，并导致CBF，CBV，OEF的改变。在这项拟议的工作中，我们将开发一个新的MRI脉冲序列来定量OEF，验证其对PET的准确性和可靠性。

项目成果

Regional Frontal Perfusion Deficits in Relapsing-Remitting Multiple Sclerosis with Cognitive Decline.

• DOI: 10.3174/ajnr.a4824
• 发表时间: 2016-10
• 期刊: AJNR. American journal of neuroradiology
• 作者: Vitorino R;Hojjat SP;Cantrell CG;Feinstein A;Zhang L;Lee L;O'Connor P;Carroll TJ;Aviv RI
• 通讯作者: Aviv RI

Comparison of Quantitative Cerebral Blood Flow Measurements Performed by Bookend Dynamic Susceptibility Contrast and Arterial Spin-Labeling MRI in Relapsing-Remitting Multiple Sclerosis.

• DOI: 10.3174/ajnr.a4939
• 发表时间: 2016-12
• 期刊: AJNR. American journal of neuroradiology
• 作者: D'Ortenzio RM;Hojjat SP;Vitorino R;Cantrell CG;Lee L;Feinstein A;O'Connor P;Carroll TJ;Aviv RI
• 通讯作者: Aviv RI

Spatial Correlation of Pathology and Perfusion Changes within the Cortex and White Matter in Multiple Sclerosis.

多发性硬化症皮质和白质内病理学和灌注变化的空间相关性。

• DOI: 10.3174/ajnr.a5410
• 发表时间: 2018
• 期刊: AJNR. American journal of neuroradiology
• 作者: Mulholland,AD;Vitorino,R;Hojjat,S-P;Ma,AY;Zhang,L;Lee,L;Carroll,TJ;Cantrell,CG;Figley,CR;Aviv,RI
• 通讯作者: Aviv,RI

Quantifying Intracranial Plaque Permeability with Dynamic Contrast-Enhanced MRI: A Pilot Study.

• DOI: 10.3174/ajnr.a4998
• 发表时间: 2017-02
• 期刊: AJNR. American journal of neuroradiology
• 作者: Vakil P;Elmokadem AH;Syed FH;Cantrell CG;Dehkordi FH;Carroll TJ;Ansari SA
• 通讯作者: Ansari SA