Development of Novel MR Imaging for Ischemic Stroke Evaluation

用于评估缺血性中风的新型磁共振成像的发展

基本信息

批准号：
9360577
负责人：
TIMOTHY J CARROLL
金额：
$ 46.46万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9360577
关键词：
Acute Adverse effects Affect American Heart Association Angiography Animal Model Arteries Benefits and Risks Blood Blood flow Brain Brain Edema Cause of Death Cerebral Edema Cerebral Ischemia Cerebral hemisphere hemorrhage Cerebrovascular system Cerebrum Cessation of life Chronic Clinical Detection Development Diagnosis Ensure Evaluation Evolution Financial compensation Functional Imaging Functional disorder Goals Growth Hemorrhage Hour Image Imagery Imaging technology Industrialization Infarction Intravenous Ischemia Ischemic Stroke Knowledge Light Magnetic Resonance Imaging Measures Metabolic Methods Microspheres Modeling Multicenter Trials National Institute of Neurological Disorders and Stroke Oxygen Patient Selection Patient Triage Patients Perfusion Phase Physiologic pulse Physiological Physiology Pilot Projects Predictive Value Probability Protocols documentation Reference Standards Reperfusion Injury Reperfusion Therapy Reporting Research Research Institute Research Personnel Risk Roentgen Rays Route Scanning Scientist Selection for Treatments Stroke Symptoms Techniques Thrombolytic Therapy Time Tissue Viability Tissues Triage United States National Institutes of Health Work acute stroke base bioimaging brain metabolism cerebral hemodynamics cerebrovascular design disability experience experimental study functional outcomes image reconstruction imaging biomarker imaging study improved improved outcome intravenous administration new technology novel post stroke response restoration success tissue oxygenation

项目摘要

Abstract The broad, long term goal of this research is to improve the diagnosis and treatment of ischemic stroke. In this proposed work we will develop new biomedical imaging technologies based on MRI. In light of recent MRI based imaging trials which successfully use MRI for stroke triage, there is an unmet need to improve acute phase physiologic and angiographic imaging in stroke. In this proposal we will develop, validate and perform a pilot study of new MRI pulse sequences that are capable, for the first time, the imaging of volumetric changes in cerebral perfusion, pail collateral flow, and tissue oxygenation in under 10 minutes. Our research group brings together two top-tier research institutes to interactively alter and image cerebral physiology using a novel animal model of ischemic stroke. The use of this model will allow direct visualization of the pial collateral flow, local alteration in cerebral physiology and the hypothesized response to flow augmentation therapy.

抽象的这项研究的广泛，长期的目标是改善缺血性中风的诊断和治疗。在这个拟议的工作我们将基于MRI开发新的生物医学成像技术。鉴于最近的MRI 基于成功使用MRI进行中风分流的基于成像试验，有未满足的需要改善急性中风中的相生理和血管造影成像。在此提案中，我们将开发，验证和执行对新的MRI脉冲序列的试点研究，这是第一次能够进行体积变化的成像在脑灌注中，桶状侧支流和组织氧合在10分钟内。我们的研究小组汇集了两家顶级研究机构，以互动改变和图像大脑生理学缺血性中风的新型动物模型。该模型的使用将允许直接可视化pial侧支流动，局部生理学的局部改变以及对流动增强疗法的假设反应。