Molecular Mechanisms of Neurodegeneration Scientific Conference

神经退行性变的分子机制科学会议

• 批准号: 7160618
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7160618
• 关键词: meeting /conference /symposium; neural degeneration; travel

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone meeting entitled "Molecular Mechanisms of Neurodegeneration", which will be held in Taos, New Mexico from January 16-21, 2007. Evidence is accumulating that in chronic neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) are due to a combination of events triggered by expression and accumulation of a misfolded protein that impair neuronal function. More recent developments have shown that in certain diseases a mutant RNA triggers the formation of nuclear inclusions and pathogenesis. In this meeting, emphasis will placed on understanding cellular pathways that implicated in some of the more common and intriguing neurodegenerative disorders trying to provide a foundation for their treatment.

描述（由申请人提供）：本提案旨在请求支持题为“神经退行性疾病的分子机制”的 Keystone 会议，该会议将于 2007 年 1 月 16 日至 21 日在新墨西哥州陶斯举行。慢性神经退行性疾病的证据正在积累例如阿尔茨海默病 (AD)、帕金森病 (PD)、亨廷顿病 (HD) 和肌萎缩侧索硬化症 (ALS)由于错误折叠蛋白的表达和积累所触发的一系列事件会损害神经元功能。 最近的进展表明，在某些疾病中，突变的 RNA 会引发核内含物的形成和发病机制。 在本次会议上，重点将放在了解与一些更常见和有趣的神经退行性疾病相关的细胞途径，试图为其治疗奠定基础。