Conference on the Diagnosis of Multiple System Atrophy

多系统萎缩诊断会议

• 批准号: 7113588
• 负责人: SID GILMAN
• 金额: $ 5.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113588
• 关键词: meeting /conference /symposium; nervous system disorder diagnosis; neural degeneration; travel

DESCRIPTION (provided by applicant): Recent advances in structural and functional imaging and in neuropathology have revealed distinctive changes in multiple system atrophy (MSA), and now can be added to current diagnostic guidelines, which utilize clinical criteria alone. This is a proposal to plan, develop and convene a consensus conference on the diagnosis of MSA and create a new set of diagnostic criteria incorporating recent advances in imaging and neuropathology. A Steering Committee has selected the participants from a large group of internationally recognized experts in the specific manifestations of MSA. Participants were selected based upon their expertise in the diagnosis of MSA, and special efforts were made to include women and minorities. In advance of the conference, the Steering Committee will divide the participants into five groups based upon their specific expertise, appoint a chair for each group, and give each group the task of developing draft consensus guidelines from its unique perspective. The groups include neuropathology, imaging, and the parkinsonian, cerebellar and autonomic manifestations of MSA. Upon receipt of these draft guidelines, the Steering Committee will integrate them and develop a unified draft consensus document for consideration at the conference. The conference will be convened in Boston on April 26 and 27, 2007 in association with the annual meeting of the American Academy of Neurology. Utilizing consensus methodology, the participants will develop new guidelines for the clinical diagnosis of MSA based upon the draft from the Steering Committee. The results will be incorporated into abstracts for appropriate clinical meetings and a full manuscript will be developed for publication in a prominent neurological journal. MSA, Parkinson's disease and the ataxias are within the province of interest of NINDS, which funds a program project on MSA and numerous grants in the remaining areas. Three of the participants in the current proposal are investigators in the NINDS Program Project on MSA. Relevance to public health: MSA is a progressive neurodegenerative disorder that is often mistaken for Parkinson's disease. Accurate early diagnosis is important for medical therapy of many of the treatable features of MSA and for selecting subjects for clinical trials of new medications. This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria.

描述（由申请人提供）：结构和功能成像以及神经病理学的最新进展揭示了多系统萎缩（MSA）的独特变化，现在可以添加到仅利用临床标准的当前诊断指南中。 该提案旨在规划、制定和召开关于 MSA 诊断的共识会议，并结合影像学和神经病理学的最新进展制定一套新的诊断标准。 指导委员会从一大批国际公认的 MSA 具体表现专家中挑选了参与者。 参与者是根据他们在 MSA 诊断方面的专业知识来选择的，并特别努力将女性和少数族裔纳入其中。 在会议召开之前，指导委员会将根据与会者的具体专业知识将其分为五个小组，为每个小组指定一名主席，并赋予每个小组从其独特角度制定共识指南草案的任务。 这些组包括神经病理学、影像学以及 MSA 的帕金森病、小脑和自主神经表现。 收到这些指南草案后，指导委员会将对其进行整合并制定统一的共识文件草案，供会议审议。 该会议将于2007年4月26日至27日在波士顿召开，配合美国神经病学学会年会。 参与者将利用共识方法，根据指导委员会的草案制定新的 MSA 临床诊断指南。 结果将被纳入适当临床会议的摘要中，并将编写完整的手稿以在著名的神经学杂志上发表。 MSA、帕金森病和共济失调属于 NINDS 的关注范围，该机构资助 MSA 项目以及其余领域的大量赠款。 当前提案的三名参与者是 NINDS MSA 项目的研究人员。 与公共卫生的相关性：MSA 是一种进行性神经退行性疾病，经常被误认为是帕金森病。 准确的早期诊断对于治疗 MSA 的许多可治疗特征以及选择新药物临床试验的受试者非常重要。 本次会议将通过使用新的影像学和神经病理学标准制定新的诊断指南来协助早期诊断。

项目成果

Second consensus statement on the diagnosis of multiple system atrophy.

多系统萎缩诊断第二共识声明。

• 发表时间: 2008-08-26
• 影响因子: 9.9
• 作者: Gilman, S;Wenning, G K;Low, P A;Brooks, D J;Mathias, C J;Trojanowski, J Q;Wood, N W;Colosimo, C;Dürr, A;Fowler, C J;Kaufmann, H;Klockgether, T;Lees, A;Poewe, W;Quinn, N;Revesz, T;Robertson, D;Sandroni, P;Seppi, K;Vidailhet, M
• 通讯作者: Vidailhet, M

Proposed neuroimaging criteria for the diagnosis of multiple system atrophy.

提出了诊断多系统萎缩的神经影像学标准。

• 发表时间: 2009-05-15
• 作者: Brooks, David J;Seppi, Klaus;Neuroimaging Working Group on MSA
• 通讯作者: Neuroimaging Working Group on MSA