OPTICAL IMAGING CORE

光学成像核心

• 批准号: 6946257
• 负责人: BRIAN A. HERMAN
• 金额: $ 3.03万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946257
• 关键词: aging; bioimaging /biomedical imaging; biomedical facility; computer program /software; computer system hardware; digital imaging; fluorescence microscopy; fluorescence recovery after photobleaching; fluorescence resonance energy transfer; image processing; immunofluorescence technique; molecular /cellular imaging; optics; technology /technique development; training

The Optical Imaging Core is a new addition to the arsenal of core facilities available to San Antonio Nathan Shock Center members. The comprehensive studies proposed by members of this Nathan Shock Center increasingly require multi-level, correlative analysis of the physiological processes involved in aging. As such, many studies will involve analysis of cells, tissues, and animals. To aid the progress of aging research the Optical Imaging Core will make state-of-the-art imaging technology available to all Nathan Shock Center investigators. High-end instrumentation for acquisition and analysis of optical data is expensive and requires continued maintenance and improvements. The required commitment to this technology is often difficult to maintain within individual laboratories, especially when optical imaging is not a major focus for the laboratory. Therefore, the Optical Imaging Facility fills a critical need of Nathan Shock Center investigators by housing state-of-the-art technology, by providing continued maintenance of the equipment, and by offering training and technical advice to clients. The Specific Aims are as follows: 1. To make available to the aging research community at UTHSCSA state-of-the-art optical microscopy technology for imaging of living cells, tissues, and animals. 2. To anticipate and develop new imaging based technology for aging research. 3. To provide consultation, education and assistance regarding the theory and application of optical imaging to ensure the quality of research conducted by Nathan Shock Center clients of the Optical Imaging Core. 4. To provide computer hardware and software for analysis of digital images and production of publication quality prints.

光学成像核心是圣安东尼奥内森休克中心成员可用的核心设施库中的新增成员。内森休克中心成员提出的综合研究越来越需要对衰老相关的生理过程进行多层次的相关分析。因此，许多研究将涉及细胞、组织和动物的分析。为了帮助衰老研究取得进展，光学成像核心将为所有内森休克中心的研究人员提供最先进的成像技术。用于采集和分析光学数据的高端仪器价格昂贵，并且需要 持续维护和改进。在各个实验室内通常很难维持对该技术所需的承诺，特别是当光学成像不是实验室的主要关注点时。因此，光学成像设施通过配备最先进的技术、提供持续的设备维护以及为客户提供培训和技术建议，满足了内森休克中心调查人员的迫切需求。 具体目标如下： 1. 为 UTHSCSA 的衰老研究界提供最先进的光学显微镜技术，用于活细胞、组织和动物的成像。 2. 预测和开发基于成像的新衰老研究技术。 3. 提供光学成像理论和应用方面的咨询、教育和帮助，以确保内森休克中心光学成像核心客户的研究质量。 4. 提供用于数字图像分析和制作的计算机硬件和软件 出版质量的印刷品。