ADMINISTRATIVE CORE

行政核心

• 批准号: 7233109
• 负责人: BRIAN A. HERMAN
• 金额: $ 12.94万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7233109
• 关键词: Biogenesis; Biological Assay; Cell model; Cells; Complex; Consultations; Growth; Measures; Mitochondria; Mitochondrial DNA; Mitochondrial Proteins; Mitochondrial RNA; Participant; Ploidies; Principal Investigator; Production; Protein Biosynthesis; Research; Respiration; mitochondrial DNA mutation; novel strategies; programs; respiratory; respiratory enzyme; tool

Core C will serve as the Mitochondrial Function Core of the Program Project. Dr. Bai will serve as the Leader of Core C. Core C will be responsible for the following functions in the Program Project: 1. To provide tools and analytic approachesto study mitochondrial biogenesis including mitochondria! DMA content, mitochondrial RNA level, mitochondrial protein synthesis and respiratory complex assembly, and help to quantitatively detect the mitochondrial DMAmutations for all of the principal investigators of the program project who require such analysesfor the proposed studies. 2. To provide tools and approachesto analyze mitochondrialfunction including measuring total respiration, complex-dependent respiration, growth capacitywhile cells predominantly rely on mitochondria for ATP production and ATP level, and to perform respiratory enzymesassays and create mitochondrial DNA-less cell models for the principal investigators of the program projectwho require such analysesfor the proposed studies. 3. To provide consultation regarding the availability of existing and new approachesto study mitochondrial biogenesis and function to the participants of this program project and to insure the quality of relevant research conducted by the Projects and Cores.

Core C将作为该项目的线粒体功能核心。白博士担任组长 核心C。核心C将负责计划项目中的以下功能： 1. 提供研究线粒体生物发生（包括线粒体）的工具和分析方法！ DMA 含量、线粒体 RNA 水平、线粒体蛋白质合成和呼吸复合物组装，以及 帮助所有主要研究人员定量检测线粒体 DMA 突变 需要对拟议研究进行此类分析的计划项目。 2. 提供分析线粒体功能的工具和方法，包括测量总呼吸， 复合物依赖性呼吸、生长能力，而细胞主要依赖线粒体提供 ATP 生产和 ATP 水平，并进行呼吸酶测定并创建无线粒体 DNA 项目主要研究人员的细胞模型，他们需要对拟议的研究进行此类分析 研究。 3. 就线粒体研究现有和新方法的可用性提供咨询 向该计划项目的参与者提供生物起源和功能，并确保相关的质量 由项目和核心进行的研究。