University of Iowa – 3T ESP MRI Scanner

爱荷华大学 — 3T ESP MRI 扫描仪

基本信息

批准号：
10170638
负责人：
VINCENT A MAGNOTTA
金额：
$ 195万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2023-11-30
项目状态：
已结题

项目摘要

The University of Iowa is requesting funds to acquire the GE Extreme Slewrate Performance (ESP) 3T head-only scanner. The ESP scanner provides high end gradient performance (Amplitude=115 mT/m and Slewrate=700T/m/s), which will offer significant improvements for diffusion imaging. The high slew rate performance provides a factor of two reduction in echo-spacing across all resolutions typically used for neuroimaging. Such capabilities will result in the ability to study tissue microstructure, which has been limited in the past by gradient performance. This gradient performance coupled with the MUSSELS based algorithms being developed in the Magnetic Resonance Research Facility (MRRF) will provide the ability to assess tissue microstructure at high resolution when using the high b-values needed to employ biophysical models to characterize tissue microstructure. The ESP scanner will also provide lower SAR that will enhance our T1ρ imaging efforts. In addition, the scanner provides a more friendly environment for research subjects. This scanner is needed to support the rapidly expanding neuroimaging community that was been brought about by the formation of the Iowa Neuroscience Institute (INI). The INI has hired ten faculty in the past three years that are using neuroimaging as part of their research program. We have outgrown the time available on our existing research 3T scanner and additional resources are needed to support these neuroimaging efforts. The MRRF serves as a Core University Facility and houses the only research dedicated scanning facilities in the State of Iowa. The proposed scanner would support 26 investigators with 33 NIH funded grants with an additional 15 pending NIH grants. The MRRF supports the research program of investigators from 6 colleges and 15 departments across campus. The facility also supports the research efforts from other state institutions (e.g. Iowa State University) as well as the Midwest. These investigators are a highly productive group, which study a variety of diseases including bipolar disorder, brain development, aging, neurodegenerative disorders, and cancer. The MRRF is an active research group who are undertaking the development of novel imaging sequences to support our large number of users. This includes novel imaging sequences to assess 1) tissue microstructure, 2) brain function, 3) cancer, and 4) metabolism. These projects would significantly benefit from the proposed scanner and provide future imaging capabilities for users of the facility. There is strong institution commitment for this equipment. The proposed ESP 3T scanner will be located in the $120 million Pappajohn Biomedical Discovery Building (PBDB) and the Iowa Institute for Biomedical Imaging (IIBI) was allocated 31,000 square feet of space in this building for human and animal imaging. To help support the scanner, the Department of Radiology and Biomedical Engineering have recently hired 3 additional faculty who are MR physicists. Finally, the Department of Radiology will cover the costs to install the ESP scanner and will provide financial support in case user fees are unable to cover expenses for the facility.

爱荷华大学正在申请资金购买 GE Extreme Slewrate Performance (ESP) 3T ESP 扫描仪提供高端梯度性能（振幅 = 115 mT/m 和转换速率=700T/m/s），这将为扩散成像提供显着的改进。性能可将所有通常用于的分辨率的回声间隔减少两倍这种能力将导致研究组织微观结构的能力，而这在医学领域是有限的。这种梯度性能与基于 MUSSELS 的算法相结合。磁共振研究设施（MRRF）正在开发的技术将提供评估组织的能力当使用生物物理模型所需的高 b 值时，可以以高分辨率获得微观结构 ESP 扫描仪还将提供较低的 SAR，从而增强我们的 T1ρ。此外，扫描仪的工作为研究对象提供了更友好的环境。需要扫描仪来支持快速扩展的神经影像社区爱荷华州神经科学研究所 (INI) 的成立在过去三年中聘用了 10 名教职人员。正在使用神经影像作为他们研究计划的一部分，但我们现有的时间已经不够了。需要研究 3T 扫描仪和其他资源来支持这些神经影像学工作。 MRRF 作为核心大学设施，拥有唯一的研究专用扫描设施在爱荷华州，拟议的扫描仪将为 26 名研究人员提供 33 项 NIH 资助的资助。 MRRF 还支持 6 所大学研究人员的研究计划，还有 15 项待决的 NIH 拨款。该设施还支持其他州立机构的研究工作。（例如爱荷华州立大学）以及中西部的这些研究人员是一个高产的群体。研究多种疾病，包括双相情感障碍、大脑发育、衰老、神经退行性疾病、 MRRF 是一个活跃的研究小组，致力于开发新型成像技术。序列来支持我们大量的用户，这包括用于评估 1) 组织的新颖成像序列。微观结构、2) 脑功能、3) 癌症和 4) 新陈代谢这些项目将大大受益。拟议的扫描仪并为该设施的用户提供未来的成像功能。该设备得到了机构的大力支持。拟议的 ESP 3T 扫描仪将位于耗资 1.2 亿美元的帕帕约翰生物医学发现大楼 (PBDB) 和爱荷华州生物医学研究所成像 (IIBI) 在这座大楼内分配了 31,000 平方英尺的空间用于人类和动物成像。为了帮助支持扫描仪，放射科和生物医学工程系最近聘请了3名最后，放射科将承担安装该设备的费用。 ESP 扫描仪将在用户费用无法支付设施费用的情况下提供财务支持。