Cyto Vision Workstation For Use In Multi-User Facility

用于多用户设施的 Cyto Vision 工作站

基本信息

批准号：
6877440
负责人：
PATRICIA A CONRAD
金额：
$ 17.8万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-05-01 至 2006-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal requests funds for the acquisition of an upright, widefield, automated, and motorized microscope, and a remote access workstation, to replace an unreliable and outmoded system we currently have in our shared resource in the Department of Genetics at Case Western Reserve University (CASE). The requested system from Applied Imaging, Inc. is a CytoVision Workstation and consists of a fully automated and motorized Zeiss Axioplan2 upright microscope with an x-y-z scanning stage, appropriate lenses and filters, a Roper Scientific CoolSnap HQ camera, and appropriate computer hardware and software for the microscope and the remote access workstation. The new system is designed to replace an inadequate and outdated Quips Genetic Workstation that is failing, and upgrade the facilities for motorization and automation. It will also meet the increasing demand within the Genetics Department and the School of Medicine for a system that can scan up to 8 slides at a time and autofocus and autocapture images, at multiple stage locations, of both fluorescently-labeled and histologically-stained specimens. The instrument will be housed in the current shared facility for examination of chromosomes, cells, tissue sections, and organisms. The imaging director is responsible for the day-to-day operation of the system and, together with an advisory committee, will oversee management of the facility. The Genetics Department and CASE will provide support for space allocation, renovation, installation, maintenance, and salary for the imaging director. The projects in this proposal depend upon multi-labeled fluorescence and histology analysis. Based on technical considerations and comparisons between instruments, the CytoVision Workstation is the best choice to meet the demanding imaging needs of the faculty at CASE.

描述（由申请人提供）：该提案要求资金用于购买直立、宽视场、自动化和电动显微镜以及远程访问工作站，以取代我们目前在部门共享资源中拥有的不可靠且过时的系统凯斯西储大学 (CASE) 遗传学。 Applied Imaging, Inc. 要求的系统是 CytoVision 工作站，由带有 x-y-z 扫描台的全自动电动 Zeiss Axioplan2 正置显微镜、适当的镜头和滤光片、Roper Scientific CoolSnap HQ 相机以及适当的计算机硬件和软件组成，用于显微镜和远程访问工作站。新系统旨在取代不完善且过时且出现故障的 Quips 基因工作站，并升级机动化和自动化设施。它还将满足遗传学系和医学院对系统日益增长的需求，该系统可以一次扫描多达 8 张载玻片，并在多个阶段位置自动对焦和自动捕获荧光标记和组织学染色样本的图像。该仪器将安装在目前的共用设施中，用于检查染色体、细胞、组织切片和生物体。成像总监负责系统的日常运营，并与咨询委员会一起监督设施的管理。遗传学部和CASE将为影像主任提供空间分配、装修、安装、维护和薪资方面的支持。该提案中的项目依赖于多标记荧光和组织学分析。基于技术考虑和仪器之间的比较，CytoVision 工作站是满足 CASE 教师苛刻的成像需求的最佳选择。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Carbonic anhydrase and soluble adenylate cyclase regulation of cystic fibrosis cellular phenotypes.

碳酸酐酶和可溶性腺苷酸环化酶对囊性纤维化细胞表型的调节。

DOI：
发表时间：
2022-03-01
期刊：
影响因子：
0
作者：
Boyne, Kathleen;Corey, Deborah A;Zhao, Pan;Lu, Binyu;Boron, Walter F;Moss, Fraser J;Kelley, Thomas J
通讯作者：
Kelley, Thomas J

Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy.

Nlrc4 炎性体的组成性激活可预防肝纤维化并促进部分肝切除术后的肝脏再生。