Prenatal & Environment Tobacco Smoke (ETS) Exposure: Effects on Child Regulation

产前

• 批准号: 7475195
• 负责人: Rina D Eiden
• 金额: $ 57.4万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7475195
• 关键词: Accounting; Adolescence; Affect; Age; Age-Months; Alcohol or Other Drugs use; Area; Arousal; Attention; Attenuated; Autonomic nervous system; Behavior; Behavioral; Birth; Blood Circulation; Characteristics; Chemicals; Child; Child Development; Childhood; Cigarette; Communication; Computer Systems Development; Condition; Conduct Disorder; Control Groups; Data Analyses; Development; Disease; Drug abuse; Drug usage; Education; Environment; Environmental Risk Factor; Environmental Tobacco Smoke; Exhibits; Exposure to; Family; Fetal Growth; Fetus; Frustration; Goals; Heart Rate; Heterogeneity; Homeostasis; Household; Infant; Informal Social Control; Institutes; Language; Language Delays; Language Development; Lead; Life; Link; Maternal Age; Measures; Mediating; Mediation; Mediator of activation protein; Methods; Modeling; Mothers; NIH Program Announcements; Nervous System Physiology; Nicotine; Numbers; Outcome; Parenting behavior; Parents; Pathway interactions; Perinatal mortality demographics; Physiological; Pregnancy; Problem behavior; Procedures; Psychopathology; Purpose; Rate; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Risk; Sampling; Score; Sinus; Sleep; Smoke; Smoker; Stimulus; System; Time; Tobacco smoke; Toddler; Toxin; Visual; Week; Woman; addiction; auditory stimulus; cigarette smoking; compliance behavior; day; design; directed attention; drug of abuse; indexing; infancy; maternal cigarette smoking; model development; non-smoker; non-smoking; parental role; postnatal; prenatal; prenatal exposure; programs; respiratory; response; scaffold; Accounting; Adolescence; Affect; Age; Age-Months; Alcohol or Other Drugs use; Area; Arousal; Attention; Attenuated; Autonomic nervous system; Behavior; Behavioral; Birth; Blood Circulation; Characteristics; Chemicals; Child; Child Development; Childhood; Cigarette; Communication; Computer Systems Development; Condition; Conduct Disorder; Control Groups; Data Analyses; Development; Disease; Drug abuse; Drug usage; Education; Environment; Environmental Risk Factor; Environmental Tobacco Smoke; Exhibits; Exposure to; Family; Fetal Growth; Fetus; Frustration; Goals; Heart Rate; Heterogeneity; Homeostasis; Household; Infant; Informal Social Control; Institutes; Language; Language Delays; Language Development; Lead; Life; Link; Maternal Age; Measures; Mediating; Mediation; Mediator of activation protein; Methods; Modeling; Mothers; NIH Program Announcements; Nervous System Physiology; Nicotine; Numbers; Outcome; Parenting behavior; Parents; Pathway interactions; Perinatal mortality demographics; Physiological; Pregnancy; Problem behavior; Procedures; Psychopathology; Purpose; Rate; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Risk; Sampling; Score; Sinus; Sleep; Smoke; Smoker; Stimulus; System; Time; Tobacco smoke; Toddler; Toxin; Visual; Week; Woman; addiction; auditory stimulus; cigarette smoking; compliance behavior; day; design; directed attention; drug of abuse; indexing; infancy; maternal cigarette smoking; model development; non-smoker; non-smoking; parental role; postnatal; prenatal; prenatal exposure; programs; respiratory; response; scaffold

DESCRIPTION (provided by applicant): The purpose of this longitudinal, multi-method study is to investigate the impact of prenatal exposure to cigarettes on the development of self-regulation over the first 2 years of life. Because most women who smoke cigarettes during pregnancy also have partners who smoke, children's exposure to environmental tobacco smoke (ETS) will also be examined. Cigarette exposure has been associated with a number of regulatory outcomes such as behavior problems, conduct disorder, and attention problems in later childhood. However, little is known about the developmental pathways to these self-regulatory outcomes among cigarette exposed children or about mediators and moderators of risk. Specific aims of this study are as follows: 1) examine direct effects of prenatal and ETS exposure on child regulation; 2) examine the association between prenatal exposure and language development and the association between language development and self-regulation at 24 months; 3) examine the role of parenting as the proximal mediator of the association between cigarette exposure and child outcomes such as reactivity and regulation at 9 and 16 months and self-regulation at 24 months; 4) examine if a cumulative family risk score, including parenting, moderates the association between cigarette exposure and child outcomes. The final sample will consist of 150 women who smoke during pregnancy and 100 non-smoking women with no ETS exposure recruited prenatally, and followed for 2 years postnatally. Assessments of physiological and behavioral reactivity and regulation will be conducted at 2, 9, and 16 months of age. These include autonomic measures such as respiratory sinus arrythmia during sleep at 2 months, and during affect arousing procedures at 9 and 16 months, as well as observational assessments of reactivity and regulation of arousal. In addition, assessments of focused attention using both physiolgoical (e.g., Heart Rate) and observational measures will be conducted at 9 and 16 months. Finally, assessments of toddler self-regulation (effortful control, compliance, behavior problems, and internalization of rules) and language development will be conducted at 24 months of age. Parenting and risk variables will be assessed at each age as potential mediators or moderators of risk. The study is guided by a developmental psychopathology framework and transactional models of child development emphasizing multiple pathways to risk. It is anticipated that this study will enrich our understanding of pathways to self-regulatory problems among children of cigarette smoking mothers and reasons for heterogeneity in outcomes among cigarette exposed toddlers.

描述（由申请人提供）：这项纵向，多方法研究的目的是调查产前暴露于香烟对生命头两年中自我调节发展的影响。由于大多数怀孕期间抽烟的妇女也有吸烟的伴侣，因此还将检查儿童接触环境烟烟（ETS）。卷烟暴露与许多调节结果有关，例如行为问题，行为障碍和童年后期的注意力问题。但是，对于卷烟儿童或风险的调解人和主持人，这些自我调节结果的发展途径知之甚少。这项研究的具体目的如下：1）检查产前和ETS暴露对儿童调节的直接影响； 2）检查产前暴露与语言发展与24个月时语言发展与自我调节之间的关联之间的关联； 3）探讨育儿作为香烟暴露与儿童结局之间关联的近端介体的作用，例如9和16个月的反应性和调节，以及24个月时的自我调节； 4）检查累积的家庭风险评分（包括育儿）是否会节省卷烟暴露与儿童结局之间的关联。最终样本将由150名怀孕期间吸烟的妇女和100名没有ETS暴露的非吸烟妇女在产前招募，并在产后2年。生理和行为反应性和调节的评估将在2、9和16个月大时进行。这些包括在2个月的睡眠期间以及在9和16个月时影响唤醒程序的自主措施，例如呼吸道窦炎症，以及对唤醒的反应性和调节的观察性评估。此外，将在9个月和16个月的时间内使用生理学上的（例如心率）和观察措施评估集中注意力的评估。最后，将在24个月大时对幼儿自我调节（努力控制，合规，行为问题和规则内部化）的评估。育儿和风险变量将在每个年龄段评估为潜在的风险调解人或主持人。这项研究的指导下是一个发展心理病理学框架和儿童发展的交易模型，强调了多种风险途径。可以预料，这项研究将丰富我们对吸烟母亲儿童自我调节问题的途径的理解，以及在暴露的幼儿中结果异质性的原因。