A New High Performance Detector for Small Animal SPECT

用于小动物 SPECT 的新型高性能探测器

基本信息

批准号：
7394609
负责人：
VIVEK V NAGARKAR
金额：
$ 47.67万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7394609
关键词：
Ablation Academic Medical Centers Address Aging Agreement Algorithms Animals Anus Area Arizona Arts Astronomy Biological Biological Process Blood flow Calibration California Characteristics Clinical Research Collaborations Collimator Computer software Coupled Custom Data Depth Detection Development Devices Diagnosis Discipline of Nuclear Medicine Discrimination Disease Disease model Drug Industry Elements Engineering Equipment Evaluation Event Face Facility Construction Funding Category Fiber Optics Functional Imaging Future Gamma Rays Generations Goals Government Half-Life Human Hypoxia Image Imaging Techniques Incidence Individual Investments Isotopes Label Laboratories Lasers Legal patent Letters Light Localized Manufacturer Name Measures Metabolism Methods Modality Modeling Monitor Morphology Mus Nature Netherlands Noise Numbers Object Attachment Optics Output Paper Patient Care Pattern Performance Persons Pharmacologic Substance Phase Photons Physics Polishes Positioning Attribute Positron-Emission Tomography Process Property Protein Biosynthesis Protocols documentation Published Comment Purpose Radiation Radioimmunoconjugate Radioisotopes Radiolabeled Radionuclide Imaging Range Rattus Reaction Reading Records Reporting Research Research Personnel Resolution Roentgen Rays Role Rotation Sampling San Francisco Security Signal Transduction Simulate Site Small Animal Imaging Systems Specific qualifier value Staging Structure Surface System Tail Techniques Technology Testing Therapeutic Intervention Thick Time Tomography, Computed, Scanners Translations Universities Vendor Work Writing X-Ray Computed Tomography absorption base bioimaging chemical property clinical application commercialization cost design detector human disease image reconstruction imaging probe in vivo indexing innovation instrumentation interest method development novel particle pre-clinical prevent professor programs prototype quantum radiotracer receptor reconstruction retinal rods sensor single photon emission computed tomography tool transgene expression tumor

项目摘要

DESCRIPTION (provided by applicant): Among the various functional imaging techniques, SPECT maintains an important role in the study of disease models in small animals as well as in patient care. Many SPECT-labeled imaging probes that have highly specific distributions with very little background are being used to measure a wide range of biological parameters of importance in small animals including substrate metabolism, blood flow, hypoxia, protein synthesis and receptor characteristics. The utility of this important modality has been significantly enhanced in recent years by the development of methods to image transgene expression in vivo. Furthermore, SPECT is capable of dual-isotope imaging for correlating two biological processes with a single imaging study. Recent demand for small animal SPECT has also been driven by the pharmaceutical industry where in vivo quantification of biological processes to measure an agent's mechanism of action and its concentration at the site of action is necessary. Each of these applications requires excellent spatial resolution, not only because of the small scale of the details to be imaged but also for the demanding detection and estimation tasks. Unfortunately, existing SPECT instrumentation does not provide the required performance, so the development of a high-resolution detector is essential for the improvement of future SPECT systems. To address these issues, we propose to develop a novel detector based on a unique design of a scintillator coupled to a very high spatial resolution readout. Specifically, the scintillator design and fabrication will minimize the loss of resolution arising from parallax errors due to depth-of-interaction effects within the scintillator, while maintaining very high efficiency for the detection of incident radiation. This combination of scintillator and readout, when coupled to a custom designed collimator, will form a SPECT detector module that can achieve extremely fine spatial resolution and high sensitivity in a cost-effective manner. The effort subsequent to the successful development of the detector module will focus on the development of a complete small-animal SPECT system as a prototype product.

描述（由申请人提供）：在各种功能成像技术中，Spect在小动物和患者护理中疾病模型的研究中保持着重要作用。许多具有高度特异性分布的SPECT标记的成像探针正在使用很少的背景来测量小动物的广泛重要生物学参数，包括底物代谢，血流，缺氧，蛋白质合成和受体特征。近年来，通过发展体内转基因表达的方法的发展，这种重要方式的实用性显着增强。此外，SPECT能够将两个生物学过程与单个成像研究相关联的双异位成像。最新对小动物SPECT的需求也是由制药行业驱动的，在该行业中，必须在体内量化生物学过程，以衡量药物的作用机理及其在作用部位的集中度。这些应用程序中的每一个都需要出色的空间分辨率，这不仅是因为要成像的细节的规模很小，而且还需要进行苛刻的检测和估计任务。不幸的是，现有的Spect仪器无法提供所需的性能，因此高分辨率检测器的开发对于改善未来SPECT系统至关重要。为了解决这些问题，我们建议基于闪烁器的独特设计来开发一种新颖的探测器，并结合很高的空间分辨率读数。具体而言，闪烁体的设计和制造将最大程度地减少由于闪烁体内部相互作用效应引起的视差错误引起的分辨率损失，同时保持非常高的效率以检测入射辐射。当耦合到定制设计的准直仪时，闪烁体和读数的这种组合将形成一个SPECT探测器模块，该模块可以以具有成本效益的方式实现极其精细的空间分辨率和高灵敏度。成功开发探测器模块后的努力将集中在整个小动物SPECT系统作为原型产品的开发上。