Advance Veterinary Services

高级兽医服务

• 批准号: 7262331
• 负责人: Slobodan Paessler
• 金额: $ 17.24万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-03 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7262331
• 关键词: animal colony; biological models; biomedical facility; bioterrorism /chemical warfare; cooperative study; emerging infectious disease; endoscopy; host organism interaction; laparoscopy; model design /development; telemetry; ultrasonography

The primary function of the Galveston National Laboratory Advanced Veterinary Services (GAVS) Core is to support the Galveston National Laboratory's (GNL) mission on Biodefense and Emerging Infectious Diseases. The core will provide research support services, as well as training to sustain a highly skilled cadre of personnel with expertise on the development of animal models, host-pathogen relationships, and for testing of vaccines and therapeutics against aerosol challenge. The facility is designed to offer maximum flexibility, and will incorporate BSL-2/3/4 laboratories, with supporting animal research laboratories, aerobiology suites, a vivarium for small animals and non-human primates, necropsy room, and associated support spaces. However, we recognize the need to supplement or replace studies involving animals with alternative, scientifically valid approaches wherever possible, and to maximize the information gained from such studies. Our decision to establish and utilize a highly efficient skilled veterinary core facility was therefore based to a large extent on our efforts to limit the number and variety of animal species. Technologies including surgically implanted telemetric devices, laproscopic, endoscopic, and ultrasound guided tissue biopsies will be used to provide real time data with minimally invasive techniques. The core will be readily accessible and specifically designed, equipped, managed and operated to serve as a highly efficient national resource for the NIAID's Biodefense Network and other federally and non-federally supported biodefense and emerging infections research programs. In the event of a national bioterrorism or emerging disease emergency, the proposed GAVS Core will offer surge laboratory capacity, trained laboratory personnel, diagnostic, and expert consultation to local, regional, state, and national entities involved in first response and biological incident management. The GAVS Core Director, in consultation with the GNL administrative core will direct and prioritize all activities with the aim of assisting NIAID-funded biodefense investigators from institutions lacking appropriate biocontainment facilities, technology, and/or training.

加尔维斯顿国家实验室高级兽医服务（GAVS）核心的主要功能是 支持Galveston国家实验室（GNL）生物化和新兴传染性任务 疾病。核心将提供研究支持服务，并培训以维持高技能 在动物模型的发展，宿主病原体关系和 用于测试针对气溶胶挑战的疫苗和治疗剂。该设施旨在提供最大 灵活性，并将将BSL-2/3/4实验室与支持动物研究实验室相结合， 有机生物学套房，用于小动物和非人类灵长类动物的小体，死灵室和相关的室 支持空间。但是，我们认识到需要补充或代替涉及动物的研究 尽可能的替代性，科学有效的方法，并最大化从中获得的信息 这样的研究。我们决定建立和利用高效熟练的兽医核心设施的决定是 因此，在很大程度上是基于我们限制动物物种数量和种类的努力。 包括手术植入遥测设备，腹腔镜，内窥镜和超声检查在内的技术 指导的组织活检将用于提供最低侵入性技术的实时数据。核心 将很容易访问，专门设计，配备，管理和操作，以充当高度 NIAID的生物化网络以及其他联邦和非养育者的有效国家资源 支持Biodefense和新兴感染研究计划。如果发生民族生物恐怖主义或 新兴疾病紧急情况，拟议的GAVS核心将提供激增的实验室能力，培训 向本地，地区，州和国家实体的实验室人员，诊断和专家咨询 参与了第一反应和生物事件管理。 GAV核心主任与 GNL行政核心将指导和优先考虑所有活动，以协助NIAID资助 来自缺乏适当生物疗养设施，技术和/或 训练。