Advance Veterinary Services

高级兽医服务

• 批准号: 7473997
• 负责人: Slobodan Paessler
• 金额: $ 93.8万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7473997
• 关键词: Aerosols; Animal Experimentation; Animal Model; Animals; Autopsy; Biological; Biopsy; Bioterrorism; Consultations; Core Facility; Data; Development; Devices; Diagnostic; Disease; Emergency Situation; Emerging Communicable Diseases; Event; Funding; Human Resources; Implant; Infection; Institution; Invasive; Laboratories; Laboratory Personnel; Laboratory Research; Mission; Numbers; Pliability; Research; Research Personnel; Research Support; Resources; Services; Techniques; Technology; Time; Tissues; Training; Ultrasonography; base; biocontainment facility; biodefense; design; nonhuman primate; pathogen; programs; response; therapeutic vaccine; vaccine evaluation

The primary function of the Galveston National Laboratory Advanced Veterinary Services (GAVS) Core is to support the Galveston National Laboratory's (GNL) mission on Biodefense and Emerging Infectious Diseases. The core will provide research support services, as well as training to sustain a highly skilled cadre of personnel with expertise on the development of animal models, host-pathogen relationships, and for testing of vaccines and therapeutics against aerosol challenge. The facility is designed to offer maximum flexibility, and will incorporate BSL-2/3/4 laboratories, with supporting animal research laboratories, aerobiology suites, a vivarium for small animals and non-human primates, necropsy room, and associated support spaces. However, we recognize the need to supplement or replace studies involving animals with alternative, scientifically valid approaches wherever possible, and to maximize the information gained from such studies. Our decision to establish and utilize a highly efficient skilled veterinary core facility was therefore based to a large extent on our efforts to limit the number and variety of animal species. Technologies including surgically implanted telemetric devices, laproscopic, endoscopic, and ultrasound guided tissue biopsies will be used to provide real time data with minimally invasive techniques. The core will be readily accessible and specifically designed, equipped, managed and operated to serve as a highly efficient national resource for the NIAID's Biodefense Network and other federally and non-federally supported biodefense and emerging infections research programs. In the event of a national bioterrorism or emerging disease emergency, the proposed GAVS Core will offer surge laboratory capacity, trained laboratory personnel, diagnostic, and expert consultation to local, regional, state, and national entities involved in first response and biological incident management. The GAVS Core Director, in consultation with the GNL administrative core will direct and prioritize all activities with the aim of assisting NIAID-funded biodefense investigators from institutions lacking appropriate biocontainment facilities, technology, and/or training.

加尔维斯顿国家实验室高级兽医服务 (GAVS) 核心的主要职能是 支持加尔维斯顿国家实验室 (GNL) 的生物防御和新发传染病任务 疾病。该核心将提供研究支持服务，以及维持高技能人才的培训 具有动物模型开发、宿主与病原体关系等方面专业知识的骨干人员 用于测试针对气溶胶攻击的疫苗和疗法。该设施旨在提供最大程度的 灵活性，并将合并 BSL-2/3/4 实验室以及支持动物研究实验室， 有氧生物学套房、小动物和非人类灵长类动物饲养室、尸检室和相关设施 支持空间。然而，我们认识到需要补充或取代涉及动物的研究 尽可能采用替代的、科学有效的方法，并最大限度地利用从中获得的信息 这样的研究。我们决定建立和利用高效的熟练兽医核心设施 因此在很大程度上基于我们限制动物物种数量和种类的努力。 技术包括手术植入遥测设备、腹腔镜、内窥镜和超声波 引导组织活检将用于通过微创技术提供实时数据。核心 将易于访问并经过专门设计、装备、管理和操作，以作为高度 为 NIAID 生物防御网络以及其他联邦和非联邦提供高效的国家资源 支持生物防御和新出现的感染研究项目。如果发生国家生物恐怖主义或 新出现的疾病紧急情况，拟议的 GAVS 核心将提供激增的实验室能力，经过培训 实验室人员、诊断以及向地方、区域、州和国家实体提供的专家咨询 参与第一反应和生物事件管理。 GAVS 核心总监，与 GNL 行政核心将指导所有活动并确定其优先顺序，以协助 NIAID 资助的活动 来自缺乏适当生物防护设施、技术和/或的机构的生物防御调查员 训练。