Evaluating Utility Measures: Biases and Alternatives

评估效用措施：偏见和替代方案

• 批准号: 7343247
• 负责人: Eve Wittenberg
• 金额: $ 10.89万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7343247
• 关键词: Evaluating; Utility; Measures; Biases; Alternatives

Cost-effectiveness and cost-utility analysis (CEA/CUA) is increasingly used for clinical and policy decision making in health and medicine. Utilities are critical inputs to economic analyses, providing the weighting factor for the common outcome measure "quality adjusted life years." The accuracy and validity of measurement and application of utility measures are essential to producing meaningful and informative results from such analyses. The proposed research will provide insight to understand the appropriate use and application of existing utility measurement methods, and to guide the development of improvements and alternatives. It will focus on cancer, a disease for which quality of life effects are of particular importance in clinical decision making and policy. The research proposes a series of studies to investigate the measurement of utilities, to explore the application of utilities, and to develop guidelines for improvements in utility assessment methodology. The first study will employ survey research and process tracing methods to identify cognitive factors that create biases in utility assessment methods, and develop and test modifications to avoid such biases. The second study will determine whether utilities vary systematically by individuals' age, race and gender using meta analytic techniques. The research will culminate in recommendations for the use of existing utility measurement methods and values, and the construction of a framework for the development of new methods to value health. A useful by-product of the research will be estimates of utility values for cancer health states for use by CEA/CUA and other applied researchers. The candidate has studied preference and utility assessment methods and their application in her dissertation, post-doctoral research, and current position as Instructor at Massachusetts General Hospital and Harvard Medical School. She is beginning a career as a quality of life methodologist, focusing on cancer interventions. This career development award would contribute to the initiation of her independent research agenda. She will be guided in her career development by the Director of her department, the MGH Institute for Technology Assessment, as well as senior researchers in this field who have established working relationships with the candidate (including her dissertation and post-doctoral advisors). She has strong institutional support and faculty mentorship to guarantee her success in the proposed research.

成本效益和成本障碍分析（CEA/CUA）越来越多地用于临床和政策 健康和医学决策。公用事业是经济分析的关键输入，提供 共同结局度量的加权因素“质量调整了终身年份”。的准确性和有效性 公用事业措施的测量和应用对于产生有意义且内容丰富的措施至关重要 这些分析的结果。拟议的研究将为了解适当用途提供见解 以及现有实用性测量方法的应用，并指导改进的发展和 替代方案。它将专注于癌症，这种疾病的生活质量影响在 临床决策和政策。 该研究提出了一系列研究，以研究公用事业的测量，以探索 实用程序的应用，并制定改进公用事业评估方法的准则。这 首次研究将采用调查研究和过程跟踪方法来识别创造的认知因素 公用事业评估方法的偏见，并开发和测试修改以避免这种偏见。第二个 研究将确定公用事业是否会使用元的个人年龄，种族和性别进行系统变化 分析技术。该研究将最终提出有关使用现有实用程序的建议 测量方法和价值以及建造新的框架 重视健康的方法。该研究的有用副产品将是估计癌症的实用性值 卫生状态由CEA/CUA和其他应用研究人员使用。 候选人研究了偏好和公用事业评估方法及其在她中的应用 论文，博士后研究以及马萨诸塞州综合医院的当前职位 和哈佛医学院。她开始从事生活质量方法学家的职业，专注于 癌症干预措施。该职业发展奖将有助于她的独立 研究议程。她的部门主任MGH将受到她职业发展的指导 技术评估研究所以及该领域的高级研究人员 与候选人（包括她的论文和博士后顾问）的工作关系。她有 有力的机构支持和教师指导，以确保她在拟议的研究中取得成功。