LEGUME FEEDING STUDY

豆类喂养研究

• 批准号: 7378540
• 负责人: Terryl J. Hartman
• 金额: $ 6.45万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378540
• 关键词: LEGUME; FEEDING; STUDY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The working hypothesis for the beneficial effects of a high legume, low glycemic index diet is that the dietary fiber content of the food may reduce the rate of the absorption of the carbohydrates and lower the postprandial glycemic and insulinemic responses leading to a reduced level of C-peptide and other markers of insulin resistance. The high level of fermentable fibers in legumes will be degraded by colonic bacteria to short chain fatty acids, including butyrate, a molecule with demonstrated anti-inflammatory and anti-neoplastic properties. The lowering of insulin and the increase in butyrate will both lower CRP, and other biomarkers of inflammation, and will alter expression level of inflammatory and insulin related genes in fecal colonocytes. An additional hypothesis being investigated is that a high legume, high fiber diet will result in changes in circulating levels of cholecystokin (CCK), ghrelin, and leptin which will increase satiety and reduce body weight. Study Objectives: This is a randomized crossover controlled feeding study in which each participant will consume a high legume, low glycemic index diet for four weeks and a control American diet for four weeks, with a three week break between diets. These two diet periods will be weight stable. An additional diet period will be optional in which they will consume the same legume rich diet, but weight loss will be permitted. The study will have four groups of male participants: 1. previous history of adenomas and IR; 2. previous history of adenomas and not IR; 3. IR with no history of adenomas; and 4. non-IR and no history of adenomas. The primary objective is to assess an overall effect of diet on the two endpoints, C-reactive protein and C-peptide in this population. A secondary objective is to assess whether changes in these intervention-related endpoints will differ by IR status or a history of adenomas. In addition, fecal calprotectin and colonocyte RNA will be measured to assess changes in gastrointestinal inflammation.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。高豆类、低血糖指数饮食的有益作用的工作假设是，食物中的膳食纤维含量可能会降低碳水化合物的吸收率，并降低餐后血糖和胰岛素反应，从而导致碳水平降低-胰岛素抵抗的肽和其他标志物。豆类中高含量的可发酵纤维会被结肠细菌降解为短链脂肪酸，包括丁酸盐，这是一种具有抗炎和抗肿瘤特性的分子。胰岛素的降低和丁酸盐的增加都会降低CRP和其他炎症生物标志物，并会改变粪便结肠细胞中炎症和胰岛素相关基因的表达水平。正在研究的另一个假设是，高豆类、高纤维饮食会导致胆囊素（CCK）、生长素释放肽和瘦素的循环水平发生变化，从而增加饱腹感并减轻体重。 研究目标：这是一项随机交叉对照喂养研究，其中每位参与者将食用高豆类、低血糖指数饮食四个星期，并食用对照美式饮食四个星期，两次饮食之间休息三周。这两个节食期体重都会稳定。额外的节食期是可选的，在此期间他们将食用相同的富含豆类的饮食，但允许减肥。该研究将有四组男性参与者： 1. 既往有腺瘤和 IR 病史； 2. 既往有腺瘤病史，而非 IR 病史； 3. 无腺瘤病史的IR； 4. 非 IR 并且无腺瘤病史。主要目标是评估饮食对该人群中两个终点（C 反应蛋白和 C 肽）的总体影响。第二个目标是评估这些干预相关终点的变化是否会因 IR 状态或腺瘤病史而有所不同。此外，还将测量粪便钙卫蛋白和结肠细胞RNA，以评估胃肠道炎症的变化。