ANTIOXIDANT STATUS, DIET, AND EARLY PREGNANCY

抗氧化状态、饮食和怀孕早期

• 批准号: 7951339
• 负责人: Terryl J. Hartman
• 金额: $ 0.83万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951339
• 关键词: 8-hydroxy-2' -deoxyguanosine; Antioxidants; Ascorbic Acid; Biochemical Reaction; Biological Assay; Biological Markers; Carotenoids; Clinical Research; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Conceptions; Contraceptive methods; Diet; Diet Records; Dietary Practices; Embryo; Epidemiologic Studies; Failure; Funding; Goals; Grant; Human; Human Chorionic Gonadotropin; Institution; Isoprostanes; Maternal Exposure; Measures; Menstrual cycle; Oocytes; Outcome; Ovulation; Oxidative Stress; Planned Pregnancy; Pre-Eclampsia; Pregnancy; Pregnancy loss; Reactive Oxygen Species; Reproduction; Research; Research Personnel; Resources; Serum; Source; Spontaneous abortion; Time; United States National Institutes of Health; Woman; egg; men; nutrition; preterm premature rupture of membranes; prospective; reproductive; sperm function; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human reproduction is inefficient with less than one-third of fertilized human eggs likely to survive to produce a term delivery. The great majority of these failures occur in the early weeks after ovulation. The causes of these reproductive failures are substantially unknown, but evidence suggests that they may be a consequence of maternal exposures, including pre-conception nutrition, that may result in insults to the oocyte and periconceptual embryo. The goal of this prospective epidemiologic study is to evaluate the hypothesis that dietary patterns associated with increased oxidative stress result in delayed time-to-pregnancy or early loss. Reactive oxygen species (ROS) have been associated with spontaneous abortion, preeclampsia, and premature preterm rupture of the membranes in women and defective sperm function in men. ROS are formed continuously as a consequence of both biochemical reactions and external factors. We propose to conduct a cohort study of 100 healthy women planning pregnancy. The outcomes to be evaluated are time-to-pregnancy, defined as the number of menstrual cycles from the cessation of contraception to a clinically recognized pregnancy, and early, unrecognized pregnancy loss. Unrecognized pregnancy and subsequent early loss will be determined by measuring urinary human chorionic gonadotropin (hCG). Diet will be assessed prior to conception using diet records and serum assays for the antioxidant vitamins C and E, and the carotenoids. Two urinary biomarkers of oxidative stress, 8-hydroxy-2'-deoxyguanosine and F2¿-isoprostanes will be measured.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 人类生殖效率低下，只有不到三分之一的受精卵可能存活并足月分娩。这些生殖失败的原因基本上未知，但有证据表明。它们可能是母亲暴露的结果，包括受孕前的营养，可能会导致卵母细胞和围孕期胚胎受到损害。这项前瞻性流行病学研究的目的是评估饮食模式与增加有关的假设。氧化应激导致妊娠时间延迟或过早流失，活性氧 (ROS) 与女性自然流产、先兆子痫和胎膜早破有关，而男性精子功能缺陷则不断形成。我们建议对 100 名计划怀孕的健康女性进行一项队列研究，评估的结果是怀孕时间，定义为月经周期数。停止避孕至临床认可的妊娠以及早期、未发现的妊娠流产 未识别的妊娠和随后的早期流产将通过在受孕前测量尿人绒毛膜促性腺激素 (hCG) 进行评估。抗氧化剂维生素 C 和 E，以及类胡萝卜素，两种氧化应激的尿液生物标志物，8-羟基-2'-脱氧鸟苷和F2?? -将测量异前列腺素。