Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer

富含纤维的食物可治疗肥胖和预防结肠癌

基本信息

批准号：
10650165
负责人：
Terryl J. Hartman
金额：
$ 69.96万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10650165
关键词：
Adenomatous Polyps African African American population Antineoplastic Agents Apoptosis Atherosclerosis Behavior Behavior Therapy Bile Acids Biochemical Markers Biological Biological Markers Body Weight Body Weight decreased Body mass index C-reactive protein CD3 Antigens Calories Carcinogens Cd68 Cell Proliferation Chinese Chronic Chronic Disease Colon Colon Carcinoma Colonoscopy Colorectal Cancer Communities Consumption Controlled Clinical Trials Controlled Study Depressed mood Diet Diet Modification Dietary Intervention Disease Dryness Education Energy Intake Epidemiology Equilibrium Fabaceae Fasting Fatty acid glycerol esters Female Fermentation Fiber Food Gastroenterology Gastrointestinal Motility Gastrointestinal Transit Germ-Free Glucose Goals Health High-Risk Cancer Incidence Inflammation Inflammatory Instruction Insulin Insulin Resistance Intake Intervention Intervention Studies Investigation Lentils - dietary Link Lipids Longterm Follow-up Lymphocyte Macrophage Maintenance Malignant Neoplasms Measures Mediating Metabolic Metabolic Diseases Metabolic dysfunction Methods Microbe Modification Monitor Mucous Membrane Mus Non-Insulin-Dependent Diabetes Mellitus Nutritional Obesity Outcome Overweight Participant Patients Pattern Phase Phytochemical Plants Plasma Polypectomy Polyps Population Population Heterogeneity Population Intervention Populations at Risk Production Public Health Publishing Randomized Recording of previous events Reporting Research Risk Risk Factors Satiation Science Self Direction Serum Speed Testing Therapeutic Time Weight Weight Gain Weight maintenance regimen adenoma arm bean cancer biomarkers cancer risk carcinogenicity colon cancer prevention colon cancer risk colorectal cancer risk design dietary dietary control experience food consumption gut microbiota high risk high risk population insulin signaling intervention participants intraepithelial male metabolome microbial microbiome microbiota middle age mortality multimodality nutrition prevent programs randomized, clinical trials recruit response systemic inflammatory response volunteer western diet

项目摘要

Project Summary/Abstract Obesity is a significant public health concern and a well-known risk factor for colorectal cancer (CRC). Western diet, high in calories and fat and deficient in fiber-rich foods, is a key driver of metabolic diseases like obesity and CRC. High-fiber diets including foods like legumes, such as dry beans and lentils, could have favorable effects on underlying biological responses that mediate the obesity-cancer relationship including insulin signaling, chronic inflammation, gastrointestinal motility, gut microbiota changes and the balance between cell proliferation and apoptosis. We propose to build upon our previous research demonstrating that short-term strictly monitored increases in fiber-rich food consumption facilitates weight loss and suppresses biomarkers of cancer risk. The goal of the current research is to conduct a 12-month parallel arm randomized clinical trial featuring pre-portioned entrées and strategic nutritional instruction to integrate legumes into a healthy high-fiber diet pattern. Over the course of the intervention participants will receive intense education combined with behavior modification, transitioning to self-directed and finally sustainable maintenance phases. The research will target a diverse population at highest risk for CRC (recruit n=70; 50% males / 50% females), overweight and obese participants with a history of polypectomy, to test whether a high-legume, high-fiber diet will increase weight loss and suppress colonic mucosal biomarkers of cancer risk compared to a control diet. In addition, we will explore potential beneficial effects of the high-legume intervention diet on the microbiome and metabolome, gastrointestinal transit time and on systemic biomarkers of inflammation and insulin resistance. Given the 20-fold differences in CRC between populations consuming high-fiber diets and low-fiber Western diets, the results of this study may demonstrate substantial potential for dietary change to reduce mortality from CRC and other westernized diseases.

项目概要/摘要肥胖是一个重要的公共卫生问题，也是众所周知的结直肠癌 (CRC) 危险因素。西方饮食热量和脂肪含量高，缺乏富含纤维的食物，是代谢疾病的关键驱动因素，例如高纤维饮食，包括豆类食物，如干豆和扁豆，可能会导致肥胖和结直肠癌。对介导肥胖与癌症关系的潜在生物反应产生有利影响，包括胰岛素信号、慢性炎症、胃肠动力、肠道微生物群变化和平衡我们建议以我们之前的研究为基础，证明细胞增殖和细胞凋亡之间的关系。短期严格监控增加富含纤维的食物消费有利于减肥并抑制体重当前研究的目标是进行为期 12 个月的平行组随机研究。临床试验以预先分配的主菜和战略营养指导为特色，将豆类融入到健康的高纤维饮食模式在干预过程中，参与者将接受强化教育。与行为矫正相结合，过渡到自我指导和最终可持续的维护阶段。该研究将针对 CRC 风险最高的不同人群（招募 n=70；50% 男性/50% 女性），有息肉切除史的超重和肥胖参与者，以测试是否采用高豆类、高纤维饮食与对照饮食相比，会增加体重减轻并抑制癌症风险的结肠粘膜生物标志物。此外，我们将探讨高豆类干预饮食对微生物群的潜在有益影响代谢组、胃肠道传输时间以及炎症和胰岛素抵抗的全身生物标志物。鉴于食用高纤维饮食和低纤维西方饮食的人群之间 CRC 存在 20 倍的差异饮食，这项研究的结果可能表明饮食改变具有降低死亡率的巨大潜力结直肠癌和其他西化疾病。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Interactions between the environmental and human microbiota in the preservation of health and genesis of disease: symposium report.

环境与人类微生物群在保护健康和疾病发生方面的相互作用：研讨会报告。

DOI：
10.1097/mog.0000000000000817
发表时间：
2022
期刊：
Current opinion in gastroenterology
影响因子：
2.5
作者：
Ramaboli,Matsepo;Nesengani,Lucky;Katsidzira,Leolin;Haller,Dirk;Kinross,James;Ocvirk,Soeren;O'Keefe,StephenJD; andtheAfricanMicrobiomeInternationalConsortium
通讯作者：
andtheAfricanMicrobiomeInternationalConsortium