CARDIOVASCULAR DISEASE IN ADOLESCENTS WITH TYPE 2 DIABETES

患有 2 型糖尿病的青少年的心血管疾病

• 批准号: 7374554
• 负责人: Stephen R Daniels
• 金额: $ 1.77万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374554
• 关键词: CARDIOVASCULAR; DISEASE; ADOLESCENTS; TYPE; DIABETES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of type 2 diabetes mellitus has increased dramatically in adolescents. This appears to be a direct result of the increase in prevalence and severity of obesity in the pediatric population. In adults with type 2 diabetes, the risk for cardiovascular disease is quite high. It is not known if adolescents with type 2 diabetes have an equivalent high level of risk of CVD. If they do then it would be expected that they would develop clinical CVD in their late 20's or 30's. This would have important clinical implications and would suggest the need for very aggressive management of CVD risk factors and diabetes. This study is a cross-sectional evaluation of cardiac and vascular structure and function in a population of 300 adolescents with type 2 diabetes compared to an obese control group of 300 and a normal weight control group of 300 who have been matched by age, sex and race. Assessment of CVD development will be accomplished using novel non invasive imaging methods including echocardiographic measurement of cardiac structure and function, ultrasound evaluation of carotid intimal-medial thickness, central aortic pressure and augmentation index will be accomplished using the SphygomoCor Pulse Wave Analysis System and evaluation of endothelial function by brachial artery reactivity. The results of this study will fill an important gap in knowledge, will serve as the baseline for future longitudinal studies and may provide the basis for clinical strategies to prevent the development of CVD in young patients with type 2 diabetes.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。在青少年中，2型糖尿病的患病率显着增加。这似乎是小儿肥胖症患病率和严重程度的增加的直接结果。在2型糖尿病的成年人中，心血管疾病的风险很高。尚不清楚患有2型糖尿病的青少年是否具有同等的CVD风险。如果他们这样做的话，可以预期他们将在20年代或30年代后期开发临床CVD。这将具有重要的临床意义，并表明需要对CVD风险因素和糖尿病进行非常积极的管理。 这项研究是对300种型糖尿病的300个肥胖对照组的300名青少年的心脏和血管结构和功能的横截面评估，而300个正常体重对照组则按年龄，性别和种族匹配。将使用新颖的非侵入性成像方法来评估CVD开发的评估，包括心脏结构和功能的超声心动图测量，颈动脉内膜厚度的超声评估，中央主动脉压力和增强指数将使用Sphygomococor Pulse波分析系统以及通过甲状腺内膜功能的评估来完成。 这项研究的结果将填补知识的重要空白，作为未来纵向研究的基线，并可能为防止2型糖尿病年轻患者的CVD发展提供基础。