CARDIOVASCULAR DISEASE IN ADOLESCENTS WITH TYPE 2 DIABETES

患有 2 型糖尿病的青少年的心血管疾病

• 批准号: 7374554
• 负责人: Stephen R Daniels
• 金额: $ 1.77万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374554
• 关键词: CARDIOVASCULAR; DISEASE; ADOLESCENTS; TYPE; DIABETES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of type 2 diabetes mellitus has increased dramatically in adolescents. This appears to be a direct result of the increase in prevalence and severity of obesity in the pediatric population. In adults with type 2 diabetes, the risk for cardiovascular disease is quite high. It is not known if adolescents with type 2 diabetes have an equivalent high level of risk of CVD. If they do then it would be expected that they would develop clinical CVD in their late 20's or 30's. This would have important clinical implications and would suggest the need for very aggressive management of CVD risk factors and diabetes. This study is a cross-sectional evaluation of cardiac and vascular structure and function in a population of 300 adolescents with type 2 diabetes compared to an obese control group of 300 and a normal weight control group of 300 who have been matched by age, sex and race. Assessment of CVD development will be accomplished using novel non invasive imaging methods including echocardiographic measurement of cardiac structure and function, ultrasound evaluation of carotid intimal-medial thickness, central aortic pressure and augmentation index will be accomplished using the SphygomoCor Pulse Wave Analysis System and evaluation of endothelial function by brachial artery reactivity. The results of this study will fill an important gap in knowledge, will serve as the baseline for future longitudinal studies and may provide the basis for clinical strategies to prevent the development of CVD in young patients with type 2 diabetes.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。青少年中 2 型糖尿病的患病率急剧增加。这似乎是儿科人群肥胖患病率和严重程度增加的直接结果。在患有 2 型糖尿病的成年人中，患心血管疾病的风险相当高。目前尚不清楚患有 2 型糖尿病的青少年是否具有同等高水平的 CVD 风险。如果他们这样做，那么预计他们将在 20 多岁或 30 多岁时患上临床心血管疾病。这将具有重要的临床意义，并表明需要对心血管疾病危险因素和糖尿病进行非常积极的管理。 这项研究对 300 名 2 型糖尿病青少年的心脏和血管结构和功能进行了横断面评估，并与 300 名肥胖对照组和 300 名正常体重对照组进行了比较，这些对照组的年龄、性别和体重都进行了匹配。种族。 CVD发展的评估将使用新型非侵入性成像方法来完成，包括心脏结构和功能的超声心动图测量、颈动脉内膜中层厚度的超声评估、中心主动脉压和增强指数将使用SphygomoCor脉搏波分析系统来完成，以及评估内皮功能由肱动脉反应性决定。 这项研究的结果将填补一个重要的知识空白，将作为未来纵向研究的基线，并可能为预防年轻 2 型糖尿病患者发生 CVD 的临床策略提供基础。