DO DIETARY SUPPLEMENTS OF ZINC REDUCE SERUM CADMIUM LEVELS IN SMOKERS

膳食补充剂锌是否可以降低吸烟者的血清镉水平

• 批准号: 7376686
• 负责人: GARY G SCHWARTZ
• 金额: $ 1.05万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-17 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376686
• 关键词: blood; cadmium; serum; zinc

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cadmium is an environmental pollutant and known cause of kidney disease, osteoporosis and lung cancer. This occurs because in the human body, cadmium competes for a metal essential to health, zinc. Cigarettes, a major source of cadmium, create cadmium levels in smokers 4-5 times higher than in nonsmokers. Zinc is marketed to smokers as a way to reduce cadmium levels; however, whether zinc does reduce cadmium in the blood of smokers is unknown. The objective of this study is to determine if zinc supplementation in smokers will reduce the cadmium levels in their blood. Thirty smokers will be recruited to take daily oral supplements of 80mg zinc for 12 weeks with visits to GCRC approximately every two weeks to determine cadmium levels in blood and urine.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。镉是一种环境污染物，是肾脏疾病，骨质疏松和肺癌的已知原因。之所以发生这种情况，是因为在人体中，镉竞争健康对健康必不可少的金属。香烟是镉的主要来源，在吸烟者中产生的镉水平是非吸烟者的4-5倍。锌被销售给吸烟者，以降低镉水平。但是，尚不清楚锌是否确实减少吸烟者血液中的镉。这项研究的目的是确定吸烟者补充锌是否会降低血液中的镉水平。将招募30名吸烟者，每天服用80mg锌的口服补充剂12周，每两周访问GCRC，以确定血液和尿液中的镉水平。