Cadmium & Pancreatic Cancer: A Pilot Case-Control Study

镉

• 批准号: 6625908
• 负责人: GARY G SCHWARTZ
• 金额: $ 7.2万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6625908
• 关键词: biomarker; cadmium; cancer risk; clinical research; copper; creatinine; environment related neoplasm /cancer; human subject; medical outreach /case finding; neoplasm /cancer epidemiology; pancreatic islet neoplasm; patient oriented research; questionnaires; retinoid binding proteins; sample collection; smoking; urinalysis; urine; zinc

DESCRIPTION (provided by applicant): Little is known about the etiology of pancreatic cancer, which causes more than 29,000 deaths per year in the U.S. The P.I. recently proposed that cadmium is a cause of pancreatic cancer (Cancer Epidemiology, Biomarkers &Prevention, 9:139-145, 2000). Cadmium is a non-essential metal that accumulates in the human pancreas. Cadmium is known to cause pancreatic cancer in animals and is a plausible cause of pancreatic cancer in humans. We will conduct a pilot, hospital-based case-control study to determine whether exposure to cadmium, as measured by questionnaire data on dietary, occupational and recreational exposure to cadmium, and by measurements of cadmium in urine, predicts risk for pancreatic cancer. We hypothesize that, controlling for age and smoking history, reported exposure to cadmium and cadmium levels in urine will be higher from persons with pancreatic cancer than from persons without pancreatic cancer. Our Specific Aims are to: 1. Recruit 50 patients with incident cancer of the exocrine pancreas (cases) seen at Wake Forest University Baptist Medical Center (WFUBMC). 2. Recruit two sets of control patients: a. 50 patients matched on race, gender, smoking history, and age (4- 5 years) without cancer seen inthe Department of Gastroenterology (G.I.) at WFUBMC (the clinic referral population) b. 50 patients matched on race, gender, smoking history, and age (4-5 years) without cancer seen at General Internal Medicine clinics at WFUBMC (the hospital referral population). 3. Obtain informed consent, urine samples, and questionnaire data for cases and controls. 4. Analyze these data to determine risk of pancreatic cancer from: cadmium in urine, corrected for creatinine levels (a biomarker of exposure to cadmium), reported exposure to cadmium, and retinol binding protein in urine (a measure of biological effect of exposure to cadmium). 5. Secondarily, analyze urine specimens for zinc and copper and compare tile patient groups with respect to the zinc:cadmium ratio, and to the concentrations of copper.

描述（由申请人提供）： 关于胰腺癌的病因知之甚少，这会导致更多 美国P.I.每年每年29,000人死亡最近提出了这一点 镉是胰腺癌的原因（癌症流行病学，生物标志物 ＆预防，9：139-145，2000）。镉是一种非必需金属 在人类胰腺中积聚。已知镉会引起胰腺癌 在动物中，是人类胰腺癌的合理原因。 我们将进行一项基于医院的试点病例对照研究，以确定 通过问卷调查的饮食数据衡量，暴露于镉 职业和休闲接触镉，并通过测量 尿液中的镉预测胰腺癌的风险。我们假设这一点， 控制年龄和吸烟史，据报道暴露于镉和 胰腺癌患者的尿液中镉水平将更高 比没有胰腺癌的人。 我们的具体目的是： 1。招募50例外分泌胰腺癌症患者（病例） 在Wake Forest University Baptist医学中心（WFUBMC）可见。 2。招募两组对照患者： 一个。 50名患者在种族，性别，吸烟史和年龄（4-5岁）上匹配 在WFUBMC的胃肠病学系（G.I.）中没有癌症（G.I. 诊所转诊人口） b。 50名患者在种族，性别，吸烟史和年龄（4-5岁）中匹配（4-5岁） 在WFUBMC的一般内科诊所看到的没有癌症（ 医院转诊人口）。 3。获取案件的知情同意书，尿液样本和问卷数据 和控件。 4。分析这些数据以确定胰腺癌的风险： 尿液，校正肌酐水平（暴露于镉的生物标志物）， 据报道，尿液中暴露于镉和视黄醇结合蛋白（一种度量） 暴露于镉的生物学作用）。 5。其次，分析锌和铜的尿液标本并比较瓷砖 患者组相对于锌：镉比和 铜的浓度。