Metal Exposure and Early Cardiovascular Risk in Adult E-Cigarette Users

成人电子烟使用者的金属暴露和早期心血管风险

• 批准号: 10616935
• 负责人: Ana Navas-Acien
• 金额: $ 6.9万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-10 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10616935
• 关键词: Adult; Adverse effects; Age-Years; Alcohol consumption; Arsenic; Barium; Biological Markers; Black American; Blood; Body mass index; Cadmium; Cardiovascular Diseases; Cesium; Chinese American; Cirrhosis; Cities; Cobalt; Cohort Studies; Copper; Data; Development; Diabetes Mellitus; Diastolic blood pressure; Disease; Dyslipidemias; Electronic cigarette; Environmental Epidemiology; Environmental Health; Environmental Pollutants; Exposure to; Fasting; Fatty Liver; Fatty acid glycerol esters; Fibrosis; General Population; Glucose; Heart; Hepatic; Hispanic Americans; Hypertension; Insulin Resistance; Intervention Studies; Knowledge; Lead; Lipids; Liver; Liver diseases; Long-Term Effects; Longitudinal Studies; Malignant neoplasm of liver; Manganese; Manuscripts; Measures; Metabolic; Metabolic Diseases; Metabolic Marker; Metabolic syndrome; Metal exposure; Metals; Molecular Epidemiology; Molybdenum; Multi-Ethnic Study of Atherosclerosis; National Health and Nutrition Examination Survey; New York City; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Parents; Participant; Pathway interactions; Patients; Play; Population; Race; Relative Risks; Reporting; Research; Risk Factors; Role; Sampling; Scanning; Selenium; Serum; Smoker; Steatohepatitis; Strontium; Students; Thallium; Time; Tungsten; Universities; Uranium; Urine; Visit; Woman; X-Ray Computed Tomography; Zinc; cardiovascular disorder risk; cardiovascular risk factor; caucasian American; chronic liver disease; cohort; coronary artery calcification; elastography; electronic cigarette use; electronic cigarette user; former smoker; liver inflammation; liver injury; men; metabolic profile; non-alcoholic fatty liver disease; novel; parent grant; primary outcome; programs; public health intervention; recruit; skills training; systematic review; tobacco smokers; toxic metal; urinary; vaping; young adult

SUMMARY Non-alcohol fatty liver disease (NAFLD) is characterized by an accumulation of fat (steatosis) in the liver in the absence of significant alcohol consumption. It represents a leading cause of chronic liver disease in the U.S. and is believed to play a key role in metabolic disorders. Recent evidence suggests that exposure to environmental pollutants including metals and metalloids may play a role in the development of NAFLD and other metabolic outcomes. However, studies examining the association between metal exposures and liver injury in a general population are scant and most evidence is cross-sectional. In this diversity supplement, we will leverage data from two existing cohorts: the VapeScan cohort (parent R01) and the Multi-Ethnic Study of Atherosclerosis and Arsenic study (R01ES028758) to examine associations of metal exposure with metabolic profiles and hepatic steatosis in young adults (VapeScan) and adult (MESA) populations. We hypothesize that metal exposures (e.g., arsenic, cadmium, manganese), including mixtures, are associated with 1) higher levels of metabolic markers and 2) higher hepatic fat. Our specific aims are: (1) Determine the association of metals (alone and as a mixture) with metabolic factors in diverse young adults from New York City. We will use data from the Vape Scan cohort to examine the associations of metals with measures of metabolic outcomes that are risk factors of NAFLD measured in fasting serum samples (lipids, glucose) and during the examination (systolic and diastolic blood pressure and body mass index) at the baseline visit and two follow-visits over a 1.5 year period. (2) Determine the association of metal mixtures with subclinical measures of liver disease. We will use data from 6,618 participants in the MESA, a cohort study of White, Black, Hispanic, and Chinese American adults recruited from 6 U.S. cities to examine the association of metal exposure with hepatic steatosis measured by computed tomography (CT) as part of the MESA examination. This project will provide novel evidence on the role of toxic metals and the mixtures on metabolic outcomes, including liver disease, which can contribute to target modifiable disease factors of these conditions. Moreover, by providing advanced skills, training and research opportunities to an MPH student (4+1 program) with focus in Environmental and Molecular Epidemiology, this project will enhance diversity in our research team at Columbia University and down the road in the field of environmental health sciences.

概括 非酒精脂肪肝病（NAFLD）的特征是肝脏在肝脏中积累（脂肪变性） 缺乏大量饮酒。它代表了美国慢性肝病的主要原因， 据信在代谢疾病中起关键作用。最近的证据表明，暴露于环境 包括金属和金属在内的污染物可能在NAFLD和其他代谢的发展中发挥作用 结果。但是，研究了一般的金属暴露与肝损伤之间关联的研究 人口很少，大多数证据是横断面的。在这种多样性补充中，我们将利用数据 从两个现有的队列中：Vapescan队列（父r01）和动脉粥样硬化的多种族研究 砷研究（R01ES028758）检查金属暴露与代谢谱和肝的关联 年轻人（VAPESCAN）和成人（MESA）种群的脂肪变性。我们假设金属暴露（例如 砷，镉，锰），包括混合物，与1）较高水平的代谢标记有关 2）更高的肝脂肪。我们的具体目的是：（1）确定金属的关联（单独和作为一个 混合物）与纽约市不同年轻人的代谢因素。我们将使用来自 vape扫描队列以检查金属的关联以及风险的代谢结果的测量 在空腹血清样品（脂质，葡萄糖）和检查过程中测得的NAFLD因子（收缩期和 舒张压和体重指数）在基线访问和1。5年期间进行了两次后续访问。 （2）确定金属混合物与肝病亚临床测量的关联。我们将使用 来自6618名台面参与者的数据，一项对白人，黑人，西班牙裔和美国成年人的队列研究 从美国6个城市招募，以检查金属暴露与肝脂肪变性的关联 计算机断层扫描（CT）作为MESA检查的一部分。该项目将提供有关 有毒金属的作用以及混合物在包括肝病在内的代谢结局上的作用，这可能有助于靶标 这些疾病的可修改疾病因素。此外，通过提供高级技能，培训和研究 MPH学生（4+1个计划）的机会，重点是环境和分子流行病学，这 项目将在我们的哥伦比亚大学研究团队和领域的道路上提高多样性 环境健康科学。