Columbia University and Northern Plains Partnership for the Superfund Research Program

哥伦比亚大学和北部平原超级基金研究计划合作伙伴关系

• 批准号: 10707887
• 负责人: Ana Navas-Acien
• 金额: $ 192.53万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707887
• 关键词: Address; Adsorption; Adult; Affect; Area; Arizona; Arsenic; Biological; Cardiometabolic Disease; Cardiovascular Diseases; Chemistry; Cheyenne; Childhood; Collaborations; Communities; Community Outreach; Conceptions; Congresses; Data; Data Analyses; Diabetes Mellitus; Dietary Intervention; Distal; Elements; Ensure; Environment; Epidemic; Epidemiology; Etiology; Excision; Exposure to; Fractionation; Government; Hazardous Waste Sites; Health; Heart; Heart Diseases; Household; Human; Indigenous; Institution; Intervention; Isotopes; Joints; Knowledge; Laboratories; Life; Light; Longitudinal Studies; Maintenance; Measurement; Measures; Metal exposure; Metals; Modeling; Molecular; Molecular Profiling; Monitor; Mus; Native Americans; New Mexico; Nutritional status; Oxidation-Reduction; Pathway interactions; Policies; Population; Prevention; Privatization; Program Research Project Grants; Recycling; Research; Research Activity; Research Design; Research Ethics; Resolution; Risk Reduction; Role; Rural; Rural Community; Sampling; Science; Scientist; Signal Recognition Particle; Sioux Indians; Source; South Dakota; Specimen; Superfund; System; Techniques; Technology; Tissue Sample; Tissues; Toxic effect; Training; Translational Research; Treatment Failure; Tribes; United States Indian Health Service; Universities; Uranium; Urine; Water; cardiometabolism; citizen science; community engagement; complex data; contaminated drinking water; data management; disorder prevention; drinking water; early life exposure; effective intervention; epigenomics; evidence base; experience; ground water; hazardous drinking; innovation; innovative technologies; metabolomics; mouse model; multiple omics; next generation; northern Native American; northern plains; novel; photosynthetic bacteria; programs; remediation; stable isotope; success; superfund site; synergism; toxic metal; transcriptomics; tribal community; tribal lands; urinary; wasting; water quality; water sampling; well water

Summary Tribal lands are impacted by more than 15,000 hazardous waste sites and 7,000 abandoned mines that can disrupt the redox chemistry of aquifers and release toxic metals. In collaboration with tribal communities from North/South Dakota, we found that arsenic (As) and uranium (U) affect drinking water in private wells and rural water systems in the Northern Plains. Our data also show that in the 1990s/early 2000s Native Americans from the Northern Plains experienced urinary As and U levels 2.5 to 5 times higher than other US populations, likely contributing to a high burden of cardiovascular disease. Knowledge is needed on current metal exposure levels, sources (local and distal), health effects (concurrent, latent, joint), mechanistic pathways, and effective remediation systems. To address these scientific and technology gaps, we have established the Columbia University Northern Plains Superfund Research Program. This new partnership has five Projects and four Cores and will use systems science, local knowledge, and innovative technology through the following aims: (1) Develop household-level spatial and temporal models of groundwater metal concentrations integrating new measures of water As, U, and redox parameters with USGS and IHS data. These models can identify safe water vs. where mitigation interventions are needed. (2) Trace sources and cycling of metals in water and biological specimens through stable isotope measurements (U, Se) to reveal redox state and inform on local and distal sources of contamination, directly addressing our communities’ concern. (3) Determine latent and concurrent cardiometabolic effects of As and U in humans (Strong Heart As/U Lifelong study, SHAUL), and in human- relevant mouse models. These data will enhance the assessment of causality and the role of early life exposures. (4) Integrate molecular mechanisms of As and U toxicity using multi-omics (epigenomics, metabolomics) in longitudinal studies in humans (SHAUL) and mice. The cross-species comparison can identify robust signatures and mechanisms to help generate intervention strategies. (5) Develop sustainable interventions using light- based, point-of-use water remediation technology for As/U. This system will produce and recycle adsorption media with photosynthetic bacteria and alert residents before treatment failure. The Community Engagement Core will be centrally located in the Northern Plains, contributing to all research activities and local dissemination. The Data Management and Analysis and Administrative Cores will optimize use of the complex data generated while respecting tribal data sovereignty and promoting evidence-based policies and practices to address hazardous toxic metals and contribute to disease prevention. We will train the next generation of scientists in systems science, technology, Indigenous research ethics, and community outreach. The breadth, depth, and innovation of our approaches, the community’s central role, the institutional support, and our experience working together will lay the groundwork for interventions that address key concerns for water quality and human health in communities in the Northern Plains and near abandoned mines and Superfund sites.

概括 部落土地受到15,000多个危险废物地点和7,000个废弃地雷的影响 破坏含水层的氧化还原化学和释放有毒金属。与部落社区合作 北达科他州/南达科他州，我们发现砷（AS）和铀（U）影响私人井和农村的饮用水 北部平原的供水系统。我们的数据还表明，在1990年代/2000年代初期 北平原经历了AS尿和U级别的尿和U级2.5至5倍，是美国其他人群的高度2.5至5倍 导致高燃烧心血管疾病。当前金属暴露水平需要知识， 来源（本地和远端），健康效应（并发，潜在，关节），机械途径和有效 修复系统。为了解决这些科学和技术差距，我们建立了哥伦比亚 大学北部平原超级基金研究计划。这个新的合作伙伴关系有五个项目和四个核心 并将通过以下目的使用系统科学，本地知识和创新技术：（1） 开发家庭水平的空间和临时模型的地下水金属浓度集成了新的 使用USG和IHS数据的水AS，U和氧化还原参数的度量。这些型号可以识别安全的水 与需要缓解干预措施的地方。 （2）水和生物学中金属的痕量和循环 通过稳定的同位素测量（U，SE）标本以揭示氧化还原状态并告知本地和不同 污染的来源，直接解决我们社区的关注。 （3）确定潜在和并发 AS和U在人类中的心脏代谢作用（/U终生研究，Shaul）和人类 相关的鼠标模型。这些数据将增强对休闲性的评估和早期生活暴露的作用。 （4）在使用多词（表观基因组学，代谢组学）中整合AS和U毒性的分子机制 人类和小鼠的纵向研究。跨物种比较可以识别出强大的签名 以及帮助生成干预策略的机制。 （5）使用光制定可持续干预措施 基于AS/U的使用点水补救技术。该系统将产生并回收吸附 具有光合细菌的媒体和治疗失败前的居民提醒。社区参与 核心将位于北部平原，为所有研究活动和当地传播做出了贡献。 数据管理和分析以及管理核心将优化生成的复杂数据的使用 同时尊重部落数据主权并促进基于证据的政策和实践来解决 危险的有毒金属并有助于预防疾病。我们将培训下一代科学家 系统科学，技术，土著研究伦理和社区外展。广度，深度和 我们的方法的创新，社区的核心角色，机构支持以及我们的经验 在一起将为干预措施奠定基础，以解决水质和人类健康的关键问题 在北部平原的社区，附近被废弃的矿山和超级基金地点。