Diversity supplement to link research and community engagement

将研究和社区参与联系起来的多样性补充

• 批准号: 10591190
• 负责人: Weston W Porter
• 金额: $ 4.53万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10591190
• 关键词: Address; Affect; American; Area; Back; Biological Markers; Cadmium; Cadmium chloride; Carbohydrates; Chromium; Collaborations; Communities; Consumption; Data; Deposition; Development; Dose; Educational Activities; Environmental Health; Exposure to; Fatty acid glycerol esters; Foundations; Genetic; Government Programs; Health; Health Personnel; Heavy Metals; Histologic; Human; Hybrids; Individual; Inflammation; Laboratories; Lead; Lead levels; Life Experience; Link; Metal exposure; Metals; Mind; Modeling; Molecular; Mouse Strains; Mus; National Toxicology Program; Oral; Oxidative Stress; Pollution; Population; Population Genetics; Population Heterogeneity; Predisposition; Regulation; Research; Risk Assessment; Scientist; Serum; Site; Source; Texas; Tissues; Toxic effect; Toxicology; Training; United States; Urine; Water; adverse outcome; base; blood lead; career; chromium hexavalent ion; community engagement; comparative; dietary; drinking water; dysbiosis; environmental justice; experience; exposed human population; human model; interest; lead acetate; lead exposure; member; microbiome; mouse genetics; outreach; ranpirnase; response; skills; sodium bichromate; stressor; toxicant; transcriptome sequencing; Address; Affect; American; Area; Back; Biological Markers; Cadmium; Cadmium chloride; Carbohydrates; Chromium; Collaborations; Communities; Consumption; Data; Deposition; Development; Dose; Educational Activities; Environmental Health; Exposure to; Fatty acid glycerol esters; Foundations; Genetic; Government Programs; Health; Health Personnel; Heavy Metals; Histologic; Human; Hybrids; Individual; Inflammation; Laboratories; Lead; Lead levels; Life Experience; Link; Metal exposure; Metals; Mind; Modeling; Molecular; Mouse Strains; Mus; National Toxicology Program; Oral; Oxidative Stress; Pollution; Population; Population Genetics; Population Heterogeneity; Predisposition; Regulation; Research; Risk Assessment; Scientist; Serum; Site; Source; Texas; Tissues; Toxic effect; Toxicology; Training; United States; Urine; Water; adverse outcome; base; blood lead; career; chromium hexavalent ion; community engagement; comparative; dietary; drinking water; dysbiosis; environmental justice; experience; exposed human population; human model; interest; lead acetate; lead exposure; member; microbiome; mouse genetics; outreach; ranpirnase; response; skills; sodium bichromate; stressor; toxicant; transcriptome sequencing

SUMMARY Pollution has become an increasing problem with negative implications for human health. The heavy metals lead, hexavalent chromium, and cadmium have contaminated sites throughout the United States. The National Toxicology Program (NTP) has focused on investigating the toxicological effects using a single genetic background, B6C3F1. This leaves unanswered questions about how genetic background affects dose-response to these toxicants. In collaboration with members of the Texas A&M Center for Environmental Health Sciences (TICER) thematic areas of Stressors to Responses and Individuals to Populations, the genetic background affects metal deposition after single metal oral exposure to lead, hexavalent chromium, or cadmium will be investigated as an exemplar that can connect these thematic areas. To model diversity in the human population, strains from the Collaborative Cross (CC) mouse genetic reference population will be used. Using preliminary data from a large CC screen for lead deposition, four CC strains per metal treatment will be used in a standard NTP type 14-day exposure to address differences in the deposition, molecular and cellular mechanism of toxicity, and microbiome dysbiosis of lead acetate, sodium dichromate, and cadmium chloride. To better model those exposed in the US, mice will be maintained on a high-fat, high-carbohydrate American previously formulated to model the average dietary consumption of Americans. Low and high doses of these metals that model human exposures will be administered by drinking water. In addition to benefiting TICER members by demonstrating how two diverse thematic areas can be integrated, this study will provide an outstanding training platform for a scientist in training to increase the environmental health workforce and will better inform the development of more reliable toxicity ranges and establish the foundation for mechanistic studies underlying differential response to heavy metals. Additionally, the candidate will gain community engagement experience by working with the TICER Community Engagement Core to help educate communities of concern on the impact of heavy metal exposure and how TICER is addressing the health impacts. This will also allow the candidate to gain career experiences in community engagement.

概括 对人类健康的负面影响已成为越来越多的问题。重金属 铅，六价铬和镉在美国各地污染了地点。国民 毒理学计划（NTP）的重点是使用单个遗传来研究毒理学作用 背景，B6C3F1。这留下了关于遗传背景如何影响剂量反应的未解决问题 这些有毒物质。与德克萨斯A＆M环境健康科学中心的成员合作 （TICER）对反应和个人对种群的压力源的主题领域，遗传背景 单一金属口服铅，六价铬或镉会影响金属沉积 被调查为可以连接这些主题领域的示例。为了建模人口的多样性， 将使用来自协作杂交（CC）小鼠遗传参考人群的菌株。使用初步 来自铅沉积的大型CC屏幕的数据，标准中将使用四个CC菌株 NTP型14天暴露于解决沉积，分子和细胞毒性机制的差异， 乙酸铅，二色酸钠和氯化镉的微生物组营养不良。更好地建模 在美国暴露的小鼠将维持在以前配制为 对美国人的平均饮食消费进行建模。模拟人类的这些金属的低剂量和高剂量 暴露将通过饮用水进行。除了通过演示使TICER成员受益 如何整合两个不同的主题领域，这项研究将为A提供一个出色的培训平台 培训的科学家增加了环境卫生劳动力，并将更好地告知 更可靠的毒性范围并为机械研究的基础建立了差异反应的基础 重金属。此外，候选人将通过与 TICER社区参与核心，以帮助教育社区关注重金属的影响 暴露以及TICER如何解决健康影响。这也将使候选人获得职业 社区参与的经验。