The Impact of Combined Exposure to Metals and Per- and Polyfluoroalkyl Substances on Stress, Cardiovascular Disease Risk and Mortality

联合接触金属以及全氟烷基和多氟烷基物质对压力、心血管疾病风险和死亡率的影响

基本信息

批准号：
10629801
负责人：
Emmanuel Obeng-Gyasi
金额：
$ 14.16万
依托单位：
NORTH CAROLINA AGRI & TECH ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2027-07-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY The health and life outcomes of individuals are intertwined with the context in which they grow and live. The totality of exposures one experiences affects health in the short term and throughout the life course. Environmental exposure to multiple contaminants can increase stress levels in individuals and neighborhoods with psychosocial stressors such as crime, drug, and alcohol misuse, and violence also taking a toll on individual and neighborhood wellbeing. In addition, the availability, organization, and quality of local institutions and infrastructure all affect health in the short and long term. Individuals are vulnerable to simultaneous exposure to an array of environmental and psychosocial stressors. Exposure to environmental pollutants such as lead (Pb), cadmium (Cd), mercury (Hg), perfluorooctane sulfonic acid (PFOS), and perfluorinated alkylated substances (PFOA) are independently associated with adverse health outcomes, but little is known about their combined effect on individual and neighborhood stress, cardiovascular disease (CVD) risk and CVD mortality. Exploring how diverse environmental pollutants combine to cause adverse health outcomes for individuals and neighborhoods is critical for promoting healthier longer lives among populations in the United States. Contextualized in the life course theory, our study seeks to close the gap in the literature on exposure to multiple contaminants to understand the combined effect of Pb, Cd, Hg, PFOS, and PFOA on (a) allostatic load, a measure of chronic individual stress, (b) Cumulative census track risk of psychosocial stress (CCRPS), a measure of neighborhood stress, CVD risk and CVD mortality. We hypothesize that multiple environmental exposures will increase individual and neighborhood level stress, CVD risk, CVD mortality. It is critical to understand the extent to which the combined effect of Pb, Cd, Hg, PFOS, and PFOA affect the outcomes in this study. Specifically, study results can be addressed through interventions for the most at risk to limit combinations of exposures to these contaminants. Study findings will produce modified data analytical techniques for modeling the combined effects of exposures while accounting for survey data design. In addition to its implications on health, this project, we will attract and train students, especially those from historically excluded student populations i.e., Black and Hispanic, to conduct research in environmental epidemiology and data analytics. In sum, the proposed research project will enhance the current understanding of the impact of multiple environmental pollutants on individual and neighborhood stress, CVD risk and mortality; this will expand the research capacity at North Carolina Agricultural and Technical State University, the nation’s largest HBCU, which is perfectly aligned with the goals of the SuRE program.

项目摘要个体的健康和生活成果与他们成长和生活的背景交织在一起。这一个经历的整体暴露会影响到短期和整个生活过程中的健康。环境暴露于多种污染物可以增加个人和社区的压力水平犯罪，毒品和滥用诸如犯罪和暴力等社会心理压力源也会造成损失此外，本地的可用性，组织和质量机构和基础设施都在短期和长期影响健康。个人容易受到一系列环境和社会心理压力源的简单暴露。暴露于环境污染物，例如铅（PB），镉（CD），汞（HG），全氟辛烷磺酸（PFO）和全氟烷基化物质（PFOA）与不利的健康结果，但对它们对个人和社区的综合影响知之甚少压力，心血管疾病（CVD）风险和CVD死亡率。探索不同的环境污染物如何结合起来为个人带来不利的健康状况和社区对于促进美国人口中更健康的寿命至关重要。在生活课程理论中，我们的研究试图缩小文献中有关暴露的差距多种污染物，以了解Pb，CD，HG，PFO和PFOA对（a）Allostatic负载的综合效应，慢性个体压力的量度，（b）累积的人口普查轨迹轨道的心理压力风险（CCRP），a 衡量邻里压力，CVD风险和CVD死亡率。我们假设多个环境暴露将增加个人和邻里水平压力，CVD风险，CVD死亡率。了解PB，CD，HG，PFO和PFOA的综合作用在多大程度上影响了至关重要的程度。这项研究的结果。具体而言，可以通过干预措施来解决研究结果的最大风险限制对这些污染物的暴露组合。研究发现将产生改良的数据分析在考虑调查数据设计时，用于建模暴露的组合效应的技术。此外对于它对健康的影响，这个项目，我们将吸引和培训学生，尤其是从历史上看的学生排除学生人群，即黑人和西班牙裔，以进行环境流行病学和数据分析。总而言之，拟议的研究项目将增强对对个人和邻里压力，CVD风险和死亡率的多种环境污染物；这会扩大美国最大的北卡罗来纳州农业和技术州立大学的研究能力 HBCU，与确定程序的目标完全一致。