Yoga for the Management of HIV-Metabolic Syndromes

瑜伽治疗艾滋病毒代谢综合症

• 批准号: 7140085
• 负责人: KEVIN E YARASHESKI
• 金额: $ 22.41万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7140085
• 关键词: AIDS therapy; HIV infections; adipose tissue; alternative medicine; antiAIDS agent; body composition; cardiovascular disorder risk; cardiovascular function; clinical research; fibrinolysis; glucose tolerance; glucose tolerance test; helper T lymphocyte; human subject; human therapy evaluation; inflammation; insulin sensitivity /resistance; leukocyte count; lifestyle; magnetic resonance imaging; medical complication; meditation; metabolic syndrome; oxygen consumption; patient oriented research; photon absorptiometry

DESCRIPTION (provided by applicant): The introduction of highly active antiretroviral therapy (HAART) has dramatically improved quality of life, and substantially reduced morbidity and mortality rates for people living with HIV. But, HIV-infection and HAART have been associated with a cluster of metabolic and anthropomorphic syndromes (HIV-metabolic syndrome; HIV+MS) that jeopardize long-term cardiovascular disease (CVD) risk profiles for people living with HIV. The cause of these complications is multifactorial. Few safe and effective traditional treatments (drugs, changing anti-HIV medications) have been identified. The ancient practice of a Yoga lifestyle has been re-popularized as a complementary, non-traditional treatment for metabolic, anthropomorphic, and cardiovascular disorders. Yoga provides integrated control and harmonious balance among eating habits, exercise, rest, breathing style, and the mind-body relationship through the practice of postures, muscle contraction, controlled breathing, and meditation. Holistic balance among physiologic processes provides relief from disease. We propose to objectively examine the safety and efficacy of a yoga lifestyle intervention in 26 women and 26 men infected with HIV, treated with HAART and experiencing metabolic syndromes that increase CVD risk. We hypothesize that a yoga lifestyle intervention will be safe and enhance (complement) the benefits of standard-of-care therapy for HIV+MS. Participants will be randomly assigned to continue standard-of-care therapy, or add a supervised yoga lifestyle intervention to standard-of-care therapy. Yoga lifestyle intervention will be taught and supervised by trained and experienced yoga instructors employed by Living By Design Inc., a St. Louis-based healthcare program that provides complementary and alternative rehabilitative therapies to people living with HIV (and other chronic disorders). Standardized and objective measurements of oral glucose tolerance, insulin sensitivity, serum lipid/lipoprotein levels, serum markers of fibrinolysis and inflammation, adipose tissue distribution, cardiovascular function and CVD risk will be quantified before and at the end of 4-months of therapy. Yoga lifestyle practices have not been objectively tested in the management of HIV+MS, and may offer an inexpensive, safe, effective and easy to adhere to alternative management strategy for a chronic infection with lifelong implications for CVD and other health risks.

描述（由申请人提供）：高效抗逆转录病毒疗法（HAART）的引入极大地改善了艾滋病毒感染者的生活质量，并大幅降低了发病率和死亡率。但是，HIV 感染和 HAART 与一系列代谢和拟人综合征（HIV 代谢综合征；HIV+MS）相关，这些综合征危及 HIV 感染者的长期心血管疾病 (CVD) 风险状况。这些并发症的原因是多因素的。目前尚未确定安全有效的传统治疗方法（药物、更换抗艾滋病毒药物）。古老的瑜伽生活方式已重新流行起来，作为代谢、拟人化和心血管疾病的补充性非传统治疗方法。瑜伽通过姿势、肌肉收缩、控制呼吸和冥想的练习，提供饮食习惯、运动、休息、呼吸方式和身心关系之间的综合控制和和谐平衡。生理过程之间的整体平衡可以缓解疾病。我们建议对 26 名女性和 26 名感染 HIV、接受 HAART 治疗并经历增加 CVD 风险的代谢综合征的女性和 26 名男性进行客观检查瑜伽生活方式干预的安全性和有效性。我们假设瑜伽生活方式干预是安全的，并且可以增强（补充）艾滋病毒+多发性硬化症标准护理治疗的益处。参与者将被随机分配继续标准护理治疗，或在标准护理治疗中添加监督瑜伽生活方式干预。瑜伽生活方式干预将由 Living By Design Inc. 雇用的训练有素且经验丰富的瑜伽教练进行教学和监督，Living By Design Inc. 是一家位于圣路易斯的医疗保健计划，为艾滋病毒（和其他慢性疾病）感染者提供补充和替代康复疗法。口服葡萄糖耐量、胰岛素敏感性、血清脂质/脂蛋白水平、纤维蛋白溶解和炎症的血清标志物、脂肪组织分布、心血管功能和CVD风险的标准化和客观测量将在4个月的治疗之前和治疗结束时进行量化。瑜伽生活方式的实践尚未在 HIV+MS 的治疗中得到客观测试，但可能为慢性感染提供一种廉价、安全、有效且易于坚持的替代治疗策略，对 CVD 和其他健康风险具有终生影响。