YOGA FOR THE MANAGEMENT OF HIV-METABOLIC SYNDROMES

瑜伽治疗艾滋病毒代谢综合征

• 批准号: 7603354
• 负责人: KEVIN E YARASHESKI
• 金额: $ 2.97万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603354
• 关键词: Adipose tissue; Breathing; Cardiovascular Diseases; Cardiovascular Physiology; Caring; Chronic; Chronic Disease; Complement; Computer Retrieval of Information on Scientific Projects Database; Diet Habits; Disease; Drug or chemical Tissue Distribution; Educational process of instructing; Equilibrium; Exercise; Fibrinolysis; Funding; Grant; HIV; HIV Infections; HIV therapy; Health; Healthcare; Highly Active Antiretroviral Therapy; Infection; Inflammation; Institution; Life; Life Style; Lipids; Lipoproteins; Measurement; Meditation; Metabolic; Metabolic syndrome; Morbidity - disease rate; Muscle Contraction; Participant; Pharmaceutical Preparations; Physiological Processes; Posture; Quality of life; Randomized; Rate; Rehabilitation therapy; Research; Research Personnel; Resources; Rest; Risk; Safety; Serum; Serum Markers; Source; Standards of Weights and Measures; Syndrome; Testing; Training; United States National Institutes of Health; Woman; Yoga; base; body-mind; cardiovascular disorder risk; design; experience; improved; instructor; insulin sensitivity; lifestyle intervention; men; mortality; oral glucose tolerance; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The introduction of highly active antiretroviral therapy (HAART) has dramatically improved quality of life, and substantially reduced morbidity and mortality rates for people living with HIV. But, HIV-infection and HAART have been associated with a cluster of metabolic and anthropomorphic syndromes (HIV-metabolic syndrome; HIV+MS) that jeopardize long-term cardiovascular disease (CVD) risk profiles for people living with HIV. The cause of these complications is multifactorial. Few safe and effective traditional treatments (drugs, changing anti-HIV medications) have been identified. The ancient practice of a Yoga lifestyle has been re-popularized as a complementary, non-traditional treatment for metabolic, anthropomorphic, and cardiovascular disorder. Yoga provides integrated control and harmonious balance among eating habits, exercise, and rest, breathing style, and the mind-body relationship through the practice of postures, muscle contraction, controlled breathing, and meditation. Holistic balance among physiologic processes provides relief from disease. We propose to objectively examine the safety and efficacy of a yoga lifestyle intervention in 26 women and 26 men infected with HIV, treated with HAART and experiencing metabolic syndromes that increase CVD risk. We hypothesize that a yoga lifestyle intervention will be safe and enhance (complement) the benefits of standard-of-care therapy for HIV+MS. Participants will be randomly assigned to continue standard-of-care therapy, or add a supervised yoga lifestyle intervention to standard-of-care therapy. Yoga lifestyle intervention will be taught and supervised by trained and experienced yoga instructors employed by Living By Design Inc., a St. Louis-based healthcare program that provides complementary and alternative rehabilitative therapies to people living with HIV (and other chronic disorders). Standardized and objective measurements of oral glucose tolerance, insulin sensitivity, serum lipid/lipoprotein levels, serum markers of fibrinolysis and inflammation, adipose tissue distribution, cardiovascular function adn CVD risk will be quantified before and at the end of 4-months of therapy. Yoga lifestyle practices have not been objectively tested in alternative management strategy for a chronic infection with lifelong implications for CVD and other health risks.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 高效抗逆转录病毒疗法 (HAART) 的引入极大地改善了艾滋病毒感染者的生活质量，并大幅降低了发病率和死亡率。 但是，HIV 感染和 HAART 与一系列代谢和拟人综合征（HIV 代谢综合征；HIV+MS）相关，这些综合征危及 HIV 感染者的长期心血管疾病 (CVD) 风险状况。 这些并发症的原因是多因素的。 目前尚未确定安全有效的传统治疗方法（药物、更换抗艾滋病毒药物）。 古老的瑜伽生活方式已经重新流行起来，作为代谢、拟人化和心血管疾病的补充性非传统治疗方法。 瑜伽通过姿势、肌肉收缩、控制呼吸和冥想的练习，提供饮食习惯、运动和休息、呼吸方式以及身心关系之间的综合控制和和谐平衡。 生理过程之间的整体平衡可以缓解疾病。 我们建议对 26 名女性和 26 名感染 HIV、接受 HAART 治疗并经历增加 CVD 风险的代谢综合征的女性和 26 名男性进行客观检查瑜伽生活方式干预的安全性和有效性。 我们假设瑜伽生活方式干预是安全的，并且可以增强（补充）艾滋病毒+多发性硬化症标准护理治疗的益处。 参与者将被随机分配继续标准护理治疗，或在标准护理治疗中添加监督瑜伽生活方式干预。 瑜伽生活方式干预将由 Living By Design Inc. 雇用的训练有素且经验丰富的瑜伽教练进行教学和监督，Living By Design Inc. 是一家位于圣路易斯的医疗保健计划，为艾滋病毒（和其他慢性疾病）感染者提供补充和替代康复疗法。 口服葡萄糖耐量、胰岛素敏感性、血清脂质/脂蛋白水平、纤维蛋白溶解和炎症的血清标志物、脂肪组织分布、心血管功能和 CVD 风险的标准化和客观测量将在 4 个月的治疗之前和治疗结束时进行量化。 对于对心血管疾病和其他健康风险有终生影响的慢性感染，瑜伽生活方式的实践尚未在替代管理策略中得到客观测试。