Non-Invasive Instrument for Monitoring Changes in Intracranial Pressure

用于监测颅内压变化的无创仪器

• 批准号: 7223771
• 负责人: PATRICIA S JENG
• 金额: $ 18.2万
• 依托单位: MIMOSA ACOUSTICS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7223771
• 关键词: Accident and Emergency department; Acoustics; Affect; Age; Ambulances; Auditory; Blood Pressure; Blood Vessels; Brain; Brain Edema; Brain Injuries; Caring; Cessation of life; Characteristics; Clinic; Cochlea; Critical Illness; Data; Devices; Diagnosis; Diagnostic; Early identification; Evaluation; Hearing; Hemorrhage; Hospitals; Infection; Intensive Care Units; Intracranial Hypertension; Intracranial Pressure; Invaded; Invasive; Lead; Liquid substance; Measurable; Measurement; Mechanics; Methods; Monitor; Neurologic; Neurology; Noise; Outpatients; Oxygen; Patients; Perilymphatic Duct; Phase; Probability; Process; Property; Range; Risk; Structure; System; Temperature; Time; cranium; electric impedance; injured; instrument; middle ear; non-invasive system; otoacoustic emission; pressure; sound; tool; transmission process

DESCRIPTION (provided by applicant): A wide range of devastating brain injuries cause brain swelling or bleeding. Because the skull is fixed in volume, increases in the volume of its contents result in increases in intracranial pressure (ICP). Elevations of ICP can lead to worsening brain injury or death by compressing either blood vessels supplying the brain or vital brain structures themselves. Detecting and treating such increases in ICP is crucial to protecting the injured brain. Currently, the only methods to monitor ICP are invasive and require direct entry of a probe system through the skull. The major hypothesis of this proposal is that it is possible to monitor changes in intracranial pressure by non-invasive means using acoustic measurements. This method of measurement has significant advantages over current invasive measurements of monitoring ICP in that the measurements can be obtained conveniently and rapidly (in less than a minute) without invading the skull and with zero probability of infection. It is proposed to develop a practical instrument for monitoring changes in ICP using measurements of distortion product otoacoustic emissions (DPOAE) and middle ear impedance. Initial evaluation and refinement of the instrument will involve healthy normal hearing subjects on a tilt table. Subsequent evaluations will compare the instrument with the conventional invasive method of monitoring ICP with patients in the neurological intensive care unit of a major hospital. A wide range of devastating brain injuries cause brain swelling or bleeding. Because the skull is fixed in volume, increases in the volume of its contents result in increases in intracranial pressure (ICP). Elevations of ICP can lead to worsening brain injury or death by compressing either blood vessels supplying the brain or vital brain structures themselves. Detecting and treating such increases in ICP is crucial to protecting the injured brain. Currently, the only methods to monitor ICP are invasive and require direct entry of a probe system through the skull. The major hypothesis of this proposal is that it is possible to monitor changes in intracranial pressure by non-invasive means using acoustic measurements. This method of measurement has significant advantages over current invasive measurements of monitoring ICP in that the measurements can be obtained conveniently and rapidly (in less than a minute) without invading the skull and with zero probability of infection.

描述（由申请人提供）：多种毁灭性的脑损伤会导致脑肿胀或出血。由于头骨的体积固定，因此其含量的体积增加会导致颅内压（ICP）增加。 ICP的升高会通过压缩提供脑部或重要脑结构本身的血管来导致脑损伤或死亡。检测和治疗ICP中的这种增加对于保护受伤的大脑至关重要。当前，监测ICP的唯一方法是侵入性的，需要直接通过头骨进入探针系统。该提议的主要假设是，使用声学测量值可以通过非侵入性手段来监测颅内压的变化。这种测量方法比监测ICP的当前侵入性测量具有显着优势，因为可以方便，迅速（不到一分钟内）获得测量值，而无需入侵颅骨，并且感染的可能性为零。建议使用扭曲产物耳声排放（DPOAE）和中耳阻抗的测量方法来开发一种实用的工具来监测ICP的变化。该仪器的初步评估和完善将涉及倾斜表上的健康正常听力受试者。随后的评估将将该仪器与监测ICP的常规侵入性方法与大型医院神经重症监护病房中的患者进行比较。多种毁灭性的脑损伤会导致脑肿胀或出血。由于头骨的体积固定，因此其含量的体积增加会导致颅内压（ICP）增加。 ICP的升高会通过压缩提供脑部或重要脑结构本身的血管来导致脑损伤或死亡。检测和治疗ICP中的这种增加对于保护受伤的大脑至关重要。当前，监测ICP的唯一方法是侵入性的，需要直接通过头骨进入探针系统。该提议的主要假设是，使用声学测量值可以通过非侵入性手段来监测颅内压的变化。这种测量方法比监测ICP的当前侵入性测量具有显着优势，因为可以方便，迅速（不到一分钟内）获得测量值，而无需入侵颅骨，并且感染的可能性为零。